Detailed information for compound 149856

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 373.878 | Formula: C23H20ClN3
  • H donors: 2 H acceptors: 0 LogP: 4.37 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc2c(c1)C1c3[n+](C2CC1(c1c[nH]cc1)c1c[nH]cc1)cccc3.[Cl-]
  • InChi: 1S/C23H20N3.ClH/c1-2-6-19-18(5-1)21-13-23(16-8-10-24-14-16,17-9-11-25-15-17)22(19)20-7-3-4-12-26(20)21;/h1-12,14-15,21-22,24-25H,13H2;1H/q+1;/p-1
  • InChiKey: ADCFKKOLMIUWMI-UHFFFAOYSA-M  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Glutamate NMDA receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0038 0.033 0.027
Echinococcus multilocularis neuroglian 0.0057 0.0824 0.0872
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0139 0.293 0.3103
Echinococcus multilocularis roundabout 2 0.0036 0.0277 0.0293
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0047 0.0563 0.0534
Schistosoma mansoni nephrin 0.0036 0.0277 0.0293
Schistosoma mansoni vesicular amine transporter 0.0035 0.0268 0.0284
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0036 0.0277 0.023
Loa Loa (eye worm) AGC/PKA protein kinase 0.0142 0.3009 0.2966
Echinococcus granulosus tyrosine protein kinase otk 0.0033 0.0216 0.0165
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0088 0.1616 0.3232
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0088 0.1616 0.1564
Echinococcus granulosus epidermal growth factor receptor 0.0183 0.4064 0.4266
Schistosoma mansoni cell adhesion molecule 0.0036 0.0277 0.0293
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.033 0.027
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0032 0.0194 0.0141
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0277 0.0217
Echinococcus multilocularis roundabout 2 0.0036 0.0277 0.0293
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0951 0.0949
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0216 0.0155
Echinococcus granulosus cyclin dependent kinase 1 0.0088 0.1616 0.1657
Schistosoma mansoni cell adhesion molecule 0.0033 0.0216 0.0228
Echinococcus granulosus tyrosine protein kinase Src64B 0.0053 0.073 0.0713
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0033 0.0216 0.0155
Echinococcus multilocularis hemicentin 1 0.0033 0.0216 0.0228
Giardia lamblia Kinase, CMGC CDK 0.0088 0.1616 0.3232
Trypanosoma cruzi cdc2-related kinase 1 0.0088 0.1616 0.3232
Brugia malayi MAP kinase sur-1 0.0062 0.0951 0.0896
Echinococcus granulosus tyrosine protein kinase Src42A 0.0053 0.073 0.0713
Echinococcus multilocularis epidermal growth factor receptor 0.0183 0.4064 0.4303
Loa Loa (eye worm) hypothetical protein 0.0064 0.0995 0.0939
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0053 0.073 0.0773
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0951 0.1007
Schistosoma mansoni tyrosine kinase 0.0103 0.2004 0.2122
Schistosoma mansoni tyrosine kinase 0.0044 0.0488 0.0517
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.3009 0.3186
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0951 0.0896
Trichomonas vaginalis AGC family protein kinase 0.0142 0.3009 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.073 0.0713
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0088 0.1616 0.1564
Brugia malayi Furin-like cysteine rich region family protein 0.0183 0.4064 0.4027
Loa Loa (eye worm) hypothetical protein 0.0033 0.0216 0.0155
Echinococcus multilocularis lachesin 0.0033 0.0216 0.0228
Loa Loa (eye worm) hypothetical protein 0.0047 0.0563 0.0504
Brugia malayi SRC-1 0.0053 0.073 0.0673
Trichomonas vaginalis CMGC family protein kinase 0.0088 0.1616 0.3232
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0142 0.3009 0.2966
Loa Loa (eye worm) TK protein kinase 0.0045 0.0509 0.045
Giardia lamblia Kinase, AGC PKA 0.0142 0.3009 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0049 0.0621 0.0596
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.073 0.0773
Onchocerca volvulus Tyrosine kinase homolog 0.0193 0.4312 1
Leishmania major protein kinase A catalytic subunit isoform 2 0.0142 0.3009 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0142 0.3009 1
Echinococcus multilocularis insulin receptor 0.0065 0.1035 0.1096
Trichomonas vaginalis CMGC family protein kinase 0.0088 0.1616 0.3232
Echinococcus multilocularis peroxidasin 0.0033 0.0216 0.0228
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0216 0.0155
Echinococcus granulosus roundabout 2 0.0036 0.0277 0.023
Echinococcus granulosus ephrin type A receptor 4 A 0.0089 0.1655 0.1698
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0032 0.0194 0.0205
Schistosoma mansoni ephrin receptor 0.0074 0.1267 0.1341
Toxoplasma gondii AGC kinase 0.0142 0.3009 1
Trypanosoma brucei cdc2-related kinase 3 0.0088 0.1616 0.3232
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0088 0.1616 0.3232
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0142 0.3009 0.3141
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.3009 0.3186
Echinococcus multilocularis tyrosine protein kinase Blk 0.0049 0.0621 0.0657
Trichomonas vaginalis CMGC family protein kinase 0.0088 0.1616 0.3232
Schistosoma mansoni nephrin 0.0059 0.0885 0.0937
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0216 0.0155
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0216 0.0155
Echinococcus granulosus neuroglian 0.0036 0.0277 0.023
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0218 0.4954 0.4922
Schistosoma mansoni cell adhesion molecule 0.0049 0.0624 0.0661
Loa Loa (eye worm) TK/EPH protein kinase 0.0092 0.1713 0.1662
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0053 0.073 0.0773
Loa Loa (eye worm) hypothetical protein 0.0038 0.033 0.027
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.073 0.0713
Brugia malayi Immunoglobulin I-set domain containing protein 0.0218 0.4954 0.4922
Loa Loa (eye worm) hypothetical protein 0.0068 0.1118 0.1063
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0394 0.9445 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0065 0.1035 0.098
Echinococcus multilocularis neuroglian 0.0036 0.0277 0.0293
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0036 0.0277 0.0217
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0061 0.0065
Schistosoma mansoni tyrosine kinase 0.0183 0.4064 0.4303
Echinococcus granulosus roundabout 2 0.0036 0.0277 0.023
Echinococcus granulosus peroxidasin 0.0033 0.0216 0.0165
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0032 0.0184 0.0195
Schistosoma mansoni tyrosine kinase 0.0092 0.1732 0.1834
Echinococcus multilocularis tyrosine protein kinase HCK 0.0045 0.0509 0.0539
Schistosoma mansoni titin 0.0033 0.0216 0.0228
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0142 0.3009 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.073 0.0773
Schistosoma mansoni cell adhesion molecule 0.0036 0.0277 0.0293
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0142 0.3009 0.3186
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0216 0.0155
Trypanosoma cruzi cdc2-related kinase 3 0.0088 0.1616 0.3232
Onchocerca volvulus 0.0064 0.0995 0.2195
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0053 0.073 0.0773
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0951 0.1007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0195 0.0134
Echinococcus granulosus cyclin dependent kinase 5 0.0088 0.1616 0.1657
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0035 0.0268 0.0284
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0038 0.0349 0.0369
Echinococcus granulosus defective proboscis extension response 0.0035 0.0268 0.0221
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0139 0.293 0.3057
Loa Loa (eye worm) hypothetical protein 0.0142 0.3009 0.2966
Schistosoma mansoni titin 0.0027 0.0061 0.0065
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.1616 0.1711
Trypanosoma cruzi cdc2-related kinase 3 0.0088 0.1616 0.3232
Echinococcus granulosus roundabout 2 0.0071 0.1179 0.1192
Loa Loa (eye worm) hypothetical protein 0.0033 0.0216 0.0155
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0035 0.0268 0.0284
Echinococcus granulosus tyrosine kinase 0.0049 0.0621 0.0596
Toxoplasma gondii AGC kinase 0.0142 0.3009 1
Brugia malayi cell division control protein 2 homolog 0.0088 0.1616 0.1564
Schistosoma mansoni tyrosine kinase 0.0065 0.1035 0.1096
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0394 0.9445 1
Echinococcus multilocularis tyrosine protein kinase otk 0.0033 0.0216 0.0228
Echinococcus multilocularis epidermal growth factor receptor 0.0103 0.2004 0.2122
Entamoeba histolytica PH domain containing protein kinase, putative 0.0142 0.3009 1
Schistosoma mansoni tyrosine kinase 0.0053 0.073 0.0773
Entamoeba histolytica cell division protein kinase 2, putative 0.0088 0.1616 0.443
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0142 0.3009 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0277 0.0217
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0033 0.0216 0.0228
Schistosoma mansoni septate junction protein 0.0033 0.0216 0.0228
Loa Loa (eye worm) hypothetical protein 0.0033 0.0216 0.0155
Loa Loa (eye worm) TK/ROR protein kinase 0.0032 0.0194 0.0133
Echinococcus granulosus tyrosine protein kinase Lyn 0.0056 0.0809 0.0797
Schistosoma mansoni tyrosine kinase 0.0053 0.073 0.0773
Echinococcus multilocularis titin 0.0027 0.0061 0.0065
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0033 0.0216 0.0228
Echinococcus multilocularis cyclin dependent kinase 1 0.0088 0.1616 0.1711
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0068 0.1097 0.1103
Echinococcus multilocularis nmda type glutamate receptor 0.0032 0.0184 0.0195
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0142 0.3009 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0068 0.1097 0.1161
Entamoeba histolytica cell division protein kinase 2, putative 0.0088 0.1616 0.443
Loa Loa (eye worm) hypothetical protein 0.0068 0.1118 0.1063
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0142 0.3009 0.3186
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0039 0.0355 0.0296
Schistosoma mansoni tyrosine kinase 0.0065 0.1035 0.1096
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.1616 0.1711
Echinococcus granulosus tyrosine protein kinase Fyn 0.0053 0.073 0.0713
Echinococcus multilocularis hemicentin 1 0.0033 0.0216 0.0228
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0216 0.0155
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0088 0.1616 0.1657
Brugia malayi Peroxidasin 0.0033 0.0216 0.0155
Echinococcus multilocularis cyclin dependent kinase 5 0.0088 0.1616 0.1711
Echinococcus multilocularis Immunoglobulin 0.0035 0.0268 0.0284
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0142 0.3009 1
Echinococcus granulosus epidermal growth factor receptor 0.0103 0.2004 0.2071
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0142 0.3009 0.3141
Entamoeba histolytica PH domain containing protein kinase, putative 0.0142 0.3009 1
Echinococcus granulosus Immunoglobulin 0.0035 0.0268 0.0221
Schistosoma mansoni tyrosine kinase 0.0103 0.2004 0.2122
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0033 0.0216 0.0155
Echinococcus granulosus neuroglian 0.0057 0.0824 0.0813
Loa Loa (eye worm) hypothetical protein 0.0033 0.0216 0.0155
Loa Loa (eye worm) hypothetical protein 0.0033 0.0216 0.0155
Brugia malayi Fibronectin type III domain containing protein 0.0038 0.033 0.027
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0035 0.0268 0.0284
Schistosoma mansoni neuroglian 0.0036 0.0277 0.0293
Echinococcus multilocularis Immunoglobulin 0.0035 0.0268 0.0284
Loa Loa (eye worm) hypothetical protein 0.0085 0.1538 0.1486
Brugia malayi hypothetical protein 0.0038 0.033 0.027
Giardia lamblia Kinase, CMGC CDK 0.0088 0.1616 0.3232
Echinococcus granulosus insulin receptor 0.0065 0.1035 0.1038
Echinococcus granulosus cyclin dependent kinase 0.0088 0.1616 0.1657
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0142 0.3009 0.3141
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0088 0.1616 0.1564
Loa Loa (eye worm) TK/EGFR protein kinase 0.0183 0.4064 0.4027
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0142 0.3009 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0103 0.2004 0.2071
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0053 0.073 0.0773
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0053 0.073 0.0773
Loa Loa (eye worm) hypothetical protein 0.0033 0.0216 0.0155
Loa Loa (eye worm) hypothetical protein 0.0036 0.0277 0.0217
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0951 0.1007
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0142 0.3009 1
Schistosoma mansoni tyrosine kinase 0.0092 0.1732 0.1834
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0036 0.0277 0.0293
Loa Loa (eye worm) hypothetical protein 0.0035 0.0268 0.0208
Brugia malayi Prion-like- 0.0033 0.0216 0.0155
Echinococcus granulosus contactin 0.0036 0.0277 0.023
Loa Loa (eye worm) SRC-1 0.0053 0.073 0.0673
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0036 0.0277 0.0293
Schistosoma mansoni septate junction protein 0.0033 0.0216 0.0228
Onchocerca volvulus 0.0161 0.3485 0.8053
Echinococcus granulosus nmda type glutamate receptor 0.0032 0.0184 0.0131
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0033 0.0216 0.0363
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0394 0.9445 1
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.3009 0.3186
Trypanosoma brucei cdc2-related kinase 1 0.0088 0.1616 0.3232
Loa Loa (eye worm) TK protein kinase 0.0415 1 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0049 0.0621 0.0596
Loa Loa (eye worm) hypothetical protein 0.0035 0.0268 0.0208
Brugia malayi Protein kinase domain containing protein 0.0088 0.1616 0.1564
Echinococcus granulosus hemicentin 1 0.0033 0.0216 0.0165
Schistosoma mansoni roundabout 0.0033 0.0216 0.0228
Echinococcus granulosus fibroblast growth factor receptor 4 0.0394 0.9445 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0053 0.073 0.0773
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0053 0.073 0.0713
Schistosoma mansoni tyrosine kinase 0.0394 0.9445 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0038 0.0349 0.0306
Brugia malayi protein-tyrosine kinase 0.0049 0.0621 0.0563
Brugia malayi Protein kinase domain containing protein 0.0065 0.1035 0.098
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0142 0.3009 0.3186
Echinococcus granulosus twitchin 0.006 0.0902 0.0896
Brugia malayi Immunoglobulin I-set domain containing protein 0.0036 0.0277 0.0217
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0053 0.073 0.0713
Leishmania major protein kinase A catalytic subunit 0.0142 0.3009 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0621 0.0657
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0142 0.3009 1
Echinococcus multilocularis roundabout 2 0.0071 0.1179 0.1249
Loa Loa (eye worm) AGC/PKA protein kinase 0.0142 0.3009 0.2966
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0053 0.073 0.0773
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0036 0.0277 0.0293
Echinococcus multilocularis ephrin type A receptor 4 A 0.0089 0.1655 0.1752
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0036 0.0277 0.0293
Leishmania major protein kinase A catalytic subunit isoform 1 0.0142 0.3009 1
Echinococcus multilocularis cyclin dependent kinase 0.0088 0.1616 0.1711
Echinococcus multilocularis 0.0054 0.0744 0.0787
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0142 0.3009 0.3186
Echinococcus granulosus tyrosine protein kinase HCK 0.0045 0.0509 0.0477
Loa Loa (eye worm) hypothetical protein 0.0035 0.0268 0.0208
Loa Loa (eye worm) TK protein kinase 0.0049 0.0621 0.0563
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0088 0.1616 0.3232
Echinococcus multilocularis tyrosine protein kinase Srms 0.0049 0.0621 0.0657
Echinococcus multilocularis cyclin dependent kinase 1 0.0088 0.1616 0.1711
Loa Loa (eye worm) hypothetical protein 0.0033 0.0216 0.0155
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0951 0.0949
Schistosoma mansoni tyrosine kinase 0.0092 0.1732 0.1834
Trypanosoma cruzi cdc2-related kinase 1 0.0088 0.1616 0.3232
Loa Loa (eye worm) hypothetical protein 0.0038 0.033 0.027
Echinococcus granulosus lachesin 0.0033 0.0216 0.0165
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0142 0.3009 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0036 0.0277 0.0293
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0142 0.3009 1
Brugia malayi ephrin receptor 1 precursor 0.0041 0.0406 0.0347

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 30 nM Inhibitory concentration of the compound against NMDA-induced cell death in cultured mouse cortical neurons ChEMBL. 7837234
IC50 (functional) = 30 nM Inhibitory concentration of the compound against NMDA-induced cell death in cultured mouse cortical neurons ChEMBL. 7837234
Ki (binding) = 3.1 nM Binding affinity at TCP site of NMDA receptor was determined in rat brain homogenate by [3H]-TCP displacement. ChEMBL. 7837234
Ki (binding) = 3.1 nM Binding affinity at TCP site of NMDA receptor was determined in rat brain homogenate by [3H]-TCP displacement. ChEMBL. 7837234

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 7837234

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.