Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0602 | 0.0602 |
Loa Loa (eye worm) | cytochrome P450 | 0.0021 | 0.4036 | 0.4036 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.8806 | 0.8871 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.8806 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.8791 | 0.9981 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.8806 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.8806 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.003 | 0.6775 | 0.5741 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.8806 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0021 | 0.4036 | 0.3654 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.8806 | 0.8871 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.8806 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0021 | 0.4036 | 0.4186 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.6775 | 0.6568 |
Brugia malayi | cytochrome P450 | 0.0021 | 0.4036 | 0.3654 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.8806 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.985 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.003 | 0.6775 | 0.5741 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0036 | 0.8791 | 0.8791 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.8806 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.7596 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.6775 | 0.6775 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.8791 | 0.9981 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.8806 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.4036 | 0.3713 |
Echinococcus multilocularis | 0.0021 | 0.4036 | 0.4186 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.003 | 0.6775 | 0.5741 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.7268 | 0.7268 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.8806 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.004 | 1 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.8806 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.7596 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.003 | 0.6775 | 0.6775 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.8806 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.8806 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.6775 | 0.6775 |
Brugia malayi | Inositol-1 | 0.0036 | 0.8806 | 0.873 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.8806 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.003 | 0.6775 | 0.5741 |
Leishmania major | cytochrome p450-like protein | 0.003 | 0.6775 | 0.5741 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.6775 | 0.6568 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0036 | 0.8791 | 0.8714 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.8806 | 0.8806 |
Schistosoma mansoni | cytochrome P450 | 0.0021 | 0.4036 | 0.3713 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.