Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0811 | 1 | 1 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.051 | 0.578 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.051 | 0.578 | 0.578 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0811 | 1 | 0.5 |
Plasmodium falciparum | polyprenol reductase, putative | 0.051 | 0.578 | 0.5 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.051 | 0.578 | 0.5 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0811 | 1 | 1 |
Plasmodium vivax | polyprenol reductase, putative | 0.051 | 0.578 | 0.5 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0811 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0811 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0811 | 1 | 0.5 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.051 | 0.578 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0811 | 1 | 1 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.051 | 0.578 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0811 | 1 | 1 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.051 | 0.578 | 0.5 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.051 | 0.578 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0811 | 1 | 1 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.051 | 0.578 | 0.5 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0811 | 1 | 1 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.051 | 0.578 | 1 |
Onchocerca volvulus | 0.051 | 0.578 | 1 | |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.051 | 0.578 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.051 | 0.578 | 0.578 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0811 | 1 | 1 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.051 | 0.578 | 0.578 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC50 (functional) | = 83.9 ug ml-1 | Antimicrobial activity against Candida albicans ATCC 10231 after 48 hrs by MTT assay | ChEMBL. | 21330140 |
MIC50 (functional) | > 100 ug ml-1 | Antimicrobial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT assay | ChEMBL. | 21330140 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.