Detailed view for PF3D7_1455900

Basic information

TDR Targets ID: 3118
Plasmodium falciparum, polyprenol reductase, putative

Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.8971 | Length (AA): 285 | MW (Da): 34405 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02544   3-oxo-5-alpha-steroid 4-dehydrogenase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016627   oxidoreductase activity, acting on the CH-CH group of donors  
GO:0016021   integral to membrane  
GO:0005737   cytoplasm  
GO:0006629   lipid metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
132 214 3rgb (C) 163 273 32.00 0.17 0.01 0.287528 2.36

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 32 hs, intra-erythrocytic - 48 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 40 hs, Sporozoite. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 24 hs, Oocyst, Male Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Ring, Female Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_129297)

Species Accession Gene Product
Arabidopsis thaliana AT1G72590   3-oxo-5-alpha-steroid 4-dehydrogenase family protein
Arabidopsis thaliana AT2G16530   putative polyprenol reductase 2
Candida albicans CaO19.7841   possible transmembrane steroid 5-alpha-reductase similar to S. cerevisiae DFG10 (YIL049W)
Candida albicans CaO19.209   possible transmembrane steroid 5-alpha-reductase similar to S. cerevisiae DFG10 (YIL049W)
Caenorhabditis elegans CELE_B0024.13   Protein B0024.13
Cryptosporidium hominis Chro.50250   similar to NC_001141 protein required for filamentous growth, cell polarity, and cellular elongation
Cryptosporidium parvum cgd5_1340   conserved hypothetical protein
Dictyostelium discoideum DDB_G0284423   hypothetical protein
Drosophila melanogaster Dmel_CG7840   CG7840 gene product from transcript CG7840-RA
Echinococcus granulosus EgrG_000674800   3 oxo 5 alpha steroid 4 dehydrogenase C terminal
Echinococcus multilocularis EmuJ_000674800   3 oxo 5 alpha steroid 4 dehydrogenase, C terminal
Homo sapiens ENSG00000128039   steroid 5 alpha-reductase 3
Loa Loa (eye worm) LOAG_12238   hypothetical protein
Mus musculus ENSMUSG00000029233   steroid 5 alpha-reductase 3
Neospora caninum NCLIV_035090   3-oxo-5-alpha-steroid 4-dehydrogenase family protein, related
Oryza sativa 4343281   Os07g0493400
Oryza sativa 4336740   Os04g0576800
Onchocerca volvulus OVOC11276  
Plasmodium berghei PBANKA_1319600   polyprenol reductase, putative
Plasmodium falciparum PF3D7_1455900   polyprenol reductase, putative
Plasmodium knowlesi PKNH_1225900   polyprenol reductase, putative
Plasmodium vivax PVX_117670   polyprenol reductase, putative
Plasmodium yoelii PY01579   dfg10 protein
Saccharomyces cerevisiae YIL049W   Dfg10p
Toxoplasma gondii TGME49_272180   3-oxo-5-alpha-steroid 4-dehydrogenase
Theileria parva TP04_0208   hypothetical protein

Essentiality

PF3D7_1455900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1319600 Plasmodium berghei Essential plasmo
TGME49_272180 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0044 0.2692 0.5
0.4318 0.2522 1
0.0496 0.3494 1
0.0045 0.2685 0.5
0.1629 0.5572 1
0.0386 0.5441 1
0.0043 0.3597 0
0.0044 1 1
0.0269 0.4728 1
0.0259 0.3916 0.5
0.0044 0.5 0.5
0.0223 0.4122 1
0.0066 0.3029 0.5
0.0097 1 0.5
0.1682 0.5565 1
0.0119 0.3398 0.5
0.0044 1 1
0.0048 0.7671 0.5
0.0295 0.5 0.5
0.1096 0.5261 0.5
0.0291 0.3261 1
0.1591 0.424 1
0.4138 0.2589 1
0.0989 0.3014 1
0.1483 0.6596 1
0.4035 0.2725 1
0.0496 0.3368 1
0.0538 0.5231 0.5
0.0198 1 0.5
0.4138 0.2589 1
0.0044 1 1
0.0366 0.456 1
0.0411 0.5047 1
0.032 0.2562 1
0.0122 0.3443 0.8722
0.0444 1 0.5
0.0844 0.5869 1
0.0201 1 0.5
0.062 0.2871 1
0.0194 1 0.5
0.0392 0.322 1
0.0211 0.5639 0.5
0.0113 0.4246 0.5
0.0053 0.3812 0.5
0.0394 0.681 0.5
0.0444 0.6168 1
0.0105 1 0.5
0.0052 0.4576 0.5
0.0053 0.5 0.5
0.0342 0.5715 0.5
0.0043 1 0.5
0.1554 0.3544 0.5812
0.0155 1 0.5
0.0378 0.4707 1
0.0555 0.3152 1
0.1554 0.3544 0.5812
0.0366 0.3132 1
0.4138 0.2589 1
0.0933 0.3572 1
0.1476 0.6522 0.5
0.009 0.3115 1
0.0996 0.3364 1
0.0043 1 0.5
0.008 0.3061 0.5
0.0253 0.3363 1
0.2295 0.6163 1
0.0355 0.5 0.5
0.0184 0.2514 1
0.0279 0.4126 1
0.1046 0.4051 1
0.1554 0.3544 0.5812
0.0668 0.2557 1
0.35 0.2629 1
0.4138 0.2589 1
0.0097 1 0.5
0.0307 0.4445 1
0.01 1 0.5
0.0043 1 0.5
0.0266 0.3291 1
0.3311 0.2651 1
0.0051 1 0.5
0.0309 0.5 0.5
0.0113 0.2725 1
0.0051 0.8747 0.5
0.0338 0.3879 1
0.005 0.257 1
0.1711 0.5682 0.5
0.0211 0.5639 0.5
0.0304 0.4297 0.5
0.0043 1 0.5
0.0433 0.612 1
0.015 0.4363 0.5
0.0066 0.3029 0.5
0.0338 0.3879 1
0.1687 0.5672 1
0.1581 0.5481 1
0.1554 0.3544 0.5812
0.2756 0.2602 1
0.0499 0.2718 1
0.0153 1 0.5
0.0342 0.2831 1
0.005 1 0.5
0.1703 0.5236 0.5
0.008 0.3061 0.5
0.0044 1 0.5
0.0229 0.5 0.5
0.0066 0.301 1
0.0404 0.4171 1
0.0201 0.4631 0.5
0.0135 0.2869 1
0.1687 0.5672 1
0.0299 0.3146 1
0.0305 0.3463 1
0.0309 0.5 0.5
0.0129 0.289 0.5
0.0043 1 0.5
0.1243 0.5928 0.5
0.1682 0.5565 1
0.1554 0.3544 0.5812
0.079 0.4926 0.5
0.1096 0.5261 0.5
0.4318 0.252 1
0.0135 0.3062 1
0.4035 0.2725 1
0.0042 1 0.5
0.1554 0.3544 0.5812
0.0359 0.3037 1
0.0093 0.5 0.5
0.0051 1 0.5
0.1682 0.5565 1
0.005 0.5344 0.5
0.1622 0.5875 1
0.0099 1 0.5
0.005 0.5523 0.5
0.0488 0.2858 1
0.0555 0.3152 1
0.0213 0.6298 0.5
0.0308 0.6156 0.5
0.1629 0.5572 1
0.022 1 1
0.4259 0.2536 1
0.1554 0.3544 0.5812
0.0088 0.2846 1
0.1687 0.5672 1
0.0309 0.5 0.5
0.1629 0.5572 1
0.049 0.2727 1
0.0192 0.2683 1
0.1711 0.5682 0.5
0.0044 1 0.5
0.0933 0.3572 1
0.0101 1 0.5
0.0433 0.612 1
0.0043 0.5 0.5
0.0126 0.4083 0.5
0.0658 0.3619 1
0.0255 0.3177 1
0.0102 1 1
0.0195 0.2748 1
0.0996 0.3364 1
0.023 0.2518 1
0.0042 1 0.5
0.0844 0.5869 1
0.1571 0.5874 1
0.0042 0.3015 0.5
0.071 0.3797 0.5
0.0195 0.5927 0.5
0.0307 0.2535 1
0.0053 1 0.5
0.0359 0.3037 1
0.0307 0.2535 1
0.0051 1 0.5
0.1654 0.4908 0.5
0.1554 0.3544 0.5812
0.0137 0.2726 1
0.1581 0.5481 1
0.0043 1 0.5
0.0283 0.3836 0.5
0.0143 0.5042 1
0.0053 1 0.5
0.0044 1 0.5
0.0401 0.2707 1
0.1554 0.3544 0.5812
0.0044 0.5714 0.4956
0.008 0.3061 0.5
0.0513 0.7658 0.5
0.0045 1 0.5
0.4138 0.2589 1
0.1516 0.286 1
0.0151 0.5 0.5
0.0404 0.4171 1
0.0159 0.266 1
0.0104 1 0.5
0.0051 1 0.5
0.0098 1 0.5
0.0256 0.4166 1
0.049 0.2727 1
0.1682 0.5565 1
0.02 0.2564 1
0.0047 1 0.5
0.0051 1 0.5
0.1554 0.3544 0.5812
0.0053 0.5 0.5
0.0304 0.4297 0.5
0.0076 0.3029 0.5
0.0088 0.2846 1
0.3121 0.2582 1
0.0538 0.5231 0.5
0.0301 0.5 0.5
0.0126 0.4331 1
0.3121 0.2582 1
0.0207 1 0.5
0.1058 0.3216 1
0.0933 0.3572 1
0.0043 1 0.5
0.051 0.578 0.5
0.1571 0.5874 1
0.0132 0.4213 0.5
0.0652 0.5389 0.5
0.009 0.297 1
0.0255 0.3177 1
0.03 0.2511 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_1455900 (Plasmodium falciparum), polyprenol reductase, putative
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