Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | solanesyl-diphosphate synthase | 0.0824 | 0.358 | 0.2656 |
Leishmania major | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Chlamydia trachomatis | geranylgeranyl pyrophosphate synthase | 0.0561 | 0.1785 | 0.5 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.1765 | 1 | 0.5 |
Schistosoma mansoni | glutathione synthetase | 0.0561 | 0.1785 | 0.1785 |
Mycobacterium tuberculosis | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) | 0.1765 | 1 | 1 |
Echinococcus multilocularis | decaprenyl diphosphate synthase subunit 1 | 0.0824 | 0.358 | 0.358 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0824 | 0.358 | 0.358 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0484 | 0.1258 | 0.1258 |
Echinococcus multilocularis | prenyl (decaprenyl) diphosphate synthase | 0.0561 | 0.1785 | 0.1785 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0484 | 0.1258 | 0.1258 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0484 | 0.1258 | 0.1258 |
Mycobacterium ulcerans | polyprenyl diphosphate synthetase, GrcC1 | 0.0824 | 0.358 | 0.2185 |
Wolbachia endosymbiont of Brugia malayi | geranylgeranyl pyrophosphate synthase | 0.0824 | 0.358 | 1 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0879 | 0.3955 | 0.3955 |
Trypanosoma brucei | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Leishmania major | polyprenyl synthase, putative | 0.064 | 0.2324 | 0.1219 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Schistosoma mansoni | geranylgeranyl pyrophosphate synthase | 0.064 | 0.2324 | 0.2324 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.1765 | 1 | 1 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.1765 | 1 | 0.5 |
Echinococcus granulosus | decaprenyl diphosphate synthase subunit 1 | 0.0824 | 0.358 | 0.358 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0824 | 0.358 | 0.358 |
Echinococcus granulosus | prenyl decaprenyl diphosphate synthase | 0.0561 | 0.1785 | 0.1785 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Schistosoma mansoni | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Leishmania major | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthetase, putative | 0.0824 | 0.358 | 1 |
Plasmodium falciparum | octaprenyl pyrophosphate synthase | 0.0824 | 0.358 | 0.358 |
Echinococcus multilocularis | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Trypanosoma cruzi | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Entamoeba histolytica | geranylgeranyl pyrophosphate synthase, putative | 0.0824 | 0.358 | 1 |
Brugia malayi | geranylgeranyl pyrophosphate synthetase | 0.064 | 0.2324 | 0.2324 |
Schistosoma mansoni | trans-prenyltransferase | 0.0824 | 0.358 | 0.358 |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | 0.1765 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0484 | 0.1258 | 0.1258 |
Echinococcus granulosus | geranylgeranyl pyrophosphate synthase | 0.064 | 0.2324 | 0.2324 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1765 | 1 | 0.5 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.1765 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0484 | 0.1258 | 0.1258 |
Echinococcus multilocularis | geranylgeranyl pyrophosphate synthase | 0.064 | 0.2324 | 0.2324 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.064 | 0.2324 | 0.1219 |
Echinococcus granulosus | carbonic anhydrase II | 0.0484 | 0.1258 | 0.1258 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.064 | 0.2324 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) | 0.0824 | 0.358 | 0.5 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.1765 | 1 | 0.5 |
Trypanosoma brucei | solanesyl-diphosphate synthase, putative | 0.0824 | 0.358 | 0.2656 |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | 0.0824 | 0.358 | 0.358 |
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | 0.1765 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0565 | 0.1815 | 0.1815 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0484 | 0.1258 | 0.1258 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0484 | 0.1258 | 0.1258 |
Trypanosoma cruzi | polyprenyl synthase, putative | 0.064 | 0.2324 | 0.1219 |
Echinococcus granulosus | farnesyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Plasmodium vivax | geranylgeranyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Mycobacterium ulcerans | geranylgeranyl pyrophosphate synthase | 0.1765 | 1 | 1 |
Loa Loa (eye worm) | geranylgeranyl pyrophosphate synthetase | 0.064 | 0.2324 | 0.2324 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.