TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 452.376 | Formula: C25H23Cl2N3O
H donors: 0 H acceptors: 2 LogP: 7.09 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)n1nc2c(c1OCc1ccccc1Cl)cnc1c2CC(C)(C)CC1
InChi: 1S/C25H23Cl2N3O/c1-25(2)12-11-22-19(13-25)23-20(14-28-22)24(31-15-16-5-3-4-6-21(16)27)30(29-23)18-9-7-17(26)8-10-18/h3-10,14H,11-13,15H2,1-2H3
InChiKey: XSXHDMUABOGLFX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	gamma-aminobutyric acid (GABA) A receptor, alpha 1	Starlite/ChEMBL	References
Homo sapiens	gamma-aminobutyric acid (GABA) A receptor, alpha 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	gamma-aminobutyric acid (GABA) A receptor, alpha 1	456 aa	451 aa	30.2 %
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	gamma-aminobutyric acid (GABA) A receptor, alpha 2	451 aa	393 aa	25.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.003	0.1696	0.1696
Echinococcus granulosus	nAChR subunit	0.003	0.1696	0.1696
Plasmodium falciparum	membrane associated erythrocyte binding-like protein	0.0013	0.0604	0.1634
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0019	0.0969	0.0969
Loa Loa (eye worm)	acetylcholine receptor protein	0.0014	0.0659	0.0659
Brugia malayi	Cation transporter family protein	0.003	0.1696	0.1696
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0005	0.0078	0.0078
Brugia malayi	cathepsin L-like cysteine proteinase	0.0005	0.0078	0.0078
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0016	0.0808	0.0808
Toxoplasma gondii	PAN domain-containing protein	0.0017	0.0832	0.2342
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0014	0.0659	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0659	0.0659
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0014	0.0659	0.0659
Brugia malayi	PAN domain containing protein	0.0017	0.0832	0.0832
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Trypanosoma cruzi	hypothetical protein, conserved	0.0026	0.1412	0.1344
Onchocerca volvulus		0.0017	0.0832	0.4905
Onchocerca volvulus		0.0026	0.1412	0.8323
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0808	0.0808
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.003	0.1696	0.1696
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.016	1	1
Onchocerca volvulus		0.0014	0.0659	0.3886
Brugia malayi	PAN domain containing protein	0.0017	0.0832	0.0832
Onchocerca volvulus		0.0014	0.0659	0.3886
Schistosoma mansoni	nAChR subunit	0.003	0.1696	0.1696
Onchocerca volvulus		0.0005	0.0078	0.046
Brugia malayi	Cathepsin L-like precursor	0.0005	0.0078	0.0078
Echinococcus granulosus	cathepsin b	0.016	1	1
Schistosoma mansoni	nAChR subunit	0.003	0.1696	0.1696
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Echinococcus multilocularis	cathepsin L	0.0005	0.0078	0.0078
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0014	0.0659	0.0659
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.003	0.1696	0.1696
Schistosoma mansoni	protein kinase	0.0019	0.0969	0.0969
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0005	0.0078	0.0078
Brugia malayi	Cathepsin L-like precursor	0.0005	0.0078	0.0078
Brugia malayi	Papain family cysteine protease containing protein	0.0005	0.0078	0.0078
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0014	0.0659	0.0659
Toxoplasma gondii	kringle domain-containing protein	0.0026	0.1412	0.4142
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.003	0.1696	0.1696
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0005	0.0078	0.0078
Loa Loa (eye worm)	GABA receptor subunit	0.0016	0.0808	0.0808
Schistosoma mansoni	cathepsin B (C01 family)	0.0005	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0808	0.0808
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0014	0.0659	0.0659
Onchocerca volvulus		0.003	0.1696	1
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0014	0.0659	0.0659
Onchocerca volvulus		0.003	0.1696	1
Schistosoma mansoni	nAChR subunit	0.003	0.1696	0.1696
Toxoplasma gondii	subtilisin SUB12	0.0017	0.0832	0.2342
Toxoplasma gondii	microneme protein MIC17A	0.0017	0.0832	0.2342
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.003	0.1696	0.1696
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0053	0.3147	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0659	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0808	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0659	0.0659
Schistosoma mansoni	neurotransmitter gated ion channel	0.0014	0.0659	0.0659
Schistosoma mansoni	nAChR subunit	0.0014	0.0659	0.0659
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0014	0.0659	0.0659
Echinococcus granulosus	cathepsin l1	0.0005	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0832	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0078	0.0078
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.003	0.1696	0.1696
Brugia malayi	PAN domain containing protein	0.0017	0.0832	0.0832
Toxoplasma gondii	PAN domain-containing protein	0.0017	0.0832	0.2342
Trypanosoma brucei	RNA helicase, putative	0.0014	0.0652	0.1871
Brugia malayi	hypothetical protein	0.0014	0.0659	0.0659
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.003	0.1696	0.1696
Brugia malayi	PAN domain containing protein	0.0017	0.0832	0.0832
Onchocerca volvulus		0.0014	0.0659	0.3886
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.003	0.1696	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0659	0.0659
Schistosoma mansoni	cathepsin C	0.0005	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0078	0.0078
Brugia malayi	PAN domain containing protein	0.0017	0.0832	0.0832
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0005	0.0078	0.0078
Echinococcus granulosus	tissue type plasminogen activator	0.0026	0.1412	0.1412
Onchocerca volvulus		0.0017	0.0832	0.4905
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0808	0.0808
Schistosoma mansoni	cathepsin F (C01 family)	0.0005	0.0078	0.0078
Schistosoma mansoni	nAChR subunit	0.003	0.1696	0.1696
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0053	0.3147	0.3093
Brugia malayi	Cation transporter family protein	0.003	0.1696	0.1696
Schistosoma mansoni	protein kinase	0.0019	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0053	0.3147	0.3147
Echinococcus multilocularis	cathepsin b	0.016	1	1
Onchocerca volvulus		0.0017	0.0832	0.4905
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.003	0.1696	0.1696
Echinococcus granulosus	nAChR subunit	0.0016	0.0808	0.0808
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0017	0.0832	0.2342
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Echinococcus granulosus	cathepsin L	0.0005	0.0078	0.0078
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.016	1	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Brugia malayi	hypothetical protein	0.0014	0.0659	0.0659
Onchocerca volvulus		0.0005	0.0078	0.046
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0017	0.0832	0.2342
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0659	0.0659
Brugia malayi	PAN domain containing protein	0.0017	0.0832	0.0832
Onchocerca volvulus		0.0005	0.0078	0.046
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0659	0.0659
Toxoplasma gondii	cathepsin B	0.0053	0.3147	0.9532
Onchocerca volvulus		0.0005	0.0078	0.046
Schistosoma mansoni	hypothetical protein	0.0014	0.0652	0.0652
Onchocerca volvulus		0.0005	0.0078	0.046
Onchocerca volvulus		0.003	0.1696	1
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.003	0.1696	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0808	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0808	0.0808
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.003	0.1696	0.1696
Echinococcus granulosus	cathepsin b	0.016	1	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0019	0.0969	0.0969
Echinococcus multilocularis	tissue type plasminogen activator	0.0026	0.1412	0.1412
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.003	0.1696	0.1696
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0005	0.0078	0.0078
Toxoplasma gondii	PAN domain-containing protein	0.0017	0.0832	0.2342
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0078	0.0078
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.003	0.1696	0.1696
Brugia malayi	fibroinase precursor	0.0005	0.0078	0.0078
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.003	0.1696	0.1696
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0053	0.3147	1
Brugia malayi	excitatory GABA receptor EXP-1A	0.003	0.1696	0.1696
Echinococcus multilocularis	cysteine protease	0.0005	0.0078	0.0078
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.003	0.1696	0.1696
Loa Loa (eye worm)	ACC-1 protein	0.003	0.1696	0.1696
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase subunit type II alpha	0.0016	0.0823	0.0823
Brugia malayi	Cathepsin L-like precursor	0.0005	0.0078	0.0078
Giardia lamblia	Cathepsin B precursor	0.0053	0.3147	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0832	0.0832
Schistosoma mansoni	nAChR subunit	0.003	0.1696	0.1696
Brugia malayi	hypothetical protein	0.0014	0.0659	0.0659
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.003	0.1696	0.1696
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0005	0.0078	0.0078
Onchocerca volvulus		0.0005	0.0078	0.046
Echinococcus granulosus	glycine receptor subunit alpha 1	0.003	0.1696	0.1696
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.003	0.1696	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0659	0.0659
Brugia malayi	cathepsin F-like cysteine proteinase	0.0005	0.0078	0.0078
Onchocerca volvulus		0.0005	0.0078	0.046
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0016	0.0808	0.0808
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.016	1	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Echinococcus multilocularis	cathepsin L	0.0005	0.0078	0.0078
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.003	0.1696	0.1696
Echinococcus multilocularis	cathepsin L cysteine protease	0.0005	0.0078	0.0078
Onchocerca volvulus		0.0005	0.0078	0.046
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0659	0.0659
Loa Loa (eye worm)	cysteine protease	0.0005	0.0078	0.0078
Onchocerca volvulus		0.0016	0.0808	0.4765
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0659	0.0659
Onchocerca volvulus	Cathepsin L homolog	0.0005	0.0078	0.046
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Schistosoma mansoni	neurotransmitter gated ion channel	0.0016	0.0808	0.0808
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Brugia malayi	Papain family cysteine protease containing protein	0.0005	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Loa Loa (eye worm)	PAN domain-containing protein	0.0017	0.0832	0.0832
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.003	0.1696	0.1696
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.003	0.1696	0.1696
Loa Loa (eye worm)	TK/ROR protein kinase	0.0026	0.1412	0.1412
Echinococcus multilocularis	glycine receptor subunit beta	0.003	0.1696	0.1696
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0014	0.0659	0.0659
Plasmodium falciparum	apical membrane antigen 1	0.0055	0.3297	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.003	0.1696	0.1696
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0005	0.0078	0.0078
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.003	0.1696	0.1696
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0005	0.0078	0.0078
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.003	0.1696	0.1696
Onchocerca volvulus		0.0017	0.0832	0.4905
Onchocerca volvulus	Cathepsin L homolog	0.0005	0.0078	0.046
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.003	0.1696	0.1696
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.003	0.1696	0.1696
Echinococcus multilocularis	cathepsin L cysteine protease	0.0005	0.0078	0.0078
Leishmania major	hypothetical protein, conserved	0.0026	0.1412	0.4346
Loa Loa (eye worm)	ctsf protein	0.0005	0.0078	0.0078
Brugia malayi	Cathepsin L-like precursor	0.0005	0.0078	0.0078
Schistosoma mansoni	protein kinase	0.0019	0.0969	0.0969
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.016	1	1
Echinococcus multilocularis	cathepsin b	0.016	1	1
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0014	0.0659	0.0659
Loa Loa (eye worm)	hypothetical protein	0.016	1	1
Mycobacterium ulcerans	hypothetical protein	0.0004	0	0.5
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0005	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0659	0.0659
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0005	0.0078	0.0078
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0005	0.0078	0.0078
Toxoplasma gondii	PAN domain-containing protein	0.0017	0.0832	0.2342
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0832	0.0832
Brugia malayi	Cathepsin L-like precursor	0.0005	0.0078	0.0078
Plasmodium vivax	merozoite adhesive erythrocytic binding protein	0.0013	0.0604	0.1634
Brugia malayi	cathepsin L-like precursor	0.0005	0.0078	0.0078
Schistosoma mansoni	nAChR subunit	0.003	0.1696	0.1696
Brugia malayi	Papain family cysteine protease containing protein	0.0005	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0078	0.0078
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0053	0.3147	1
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.003	0.1696	0.1696
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0005	0.0078	0.0078
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0014	0.0659	0.0659
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.003	0.1696	0.1696
Onchocerca volvulus		0.0016	0.0808	0.4765
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Loa Loa (eye worm)	PAN domain-containing protein	0.0017	0.0832	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0832	0.0832
Onchocerca volvulus		0.003	0.1696	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0808	0.0808
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.003	0.1696	0.1696
Giardia lamblia	Cathepsin B precursor	0.0053	0.3147	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0005	0.0078	0.0078
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.003	0.1696	0.1696
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.003	0.1696	0.1696
Onchocerca volvulus		0.0005	0.0078	0.046
Onchocerca volvulus	Cathepsin F homolog	0.0005	0.0078	0.046
Onchocerca volvulus	Putative nachr subunit	0.003	0.1696	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.003	0.1696	0.1696
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0014	0.0659	0.0659
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0005	0.0078	0.0078
Loa Loa (eye worm)	PAN domain-containing protein	0.0017	0.0832	0.0832
Toxoplasma gondii	microneme protein MIC4	0.0017	0.0832	0.2342
Echinococcus multilocularis	nAChR subunit	0.003	0.1696	0.1696
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Toxoplasma gondii	PAN domain-containing protein	0.0017	0.0832	0.2342
Loa Loa (eye worm)	cathepsin B	0.0053	0.3147	0.3147
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0016	0.0808	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0659	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0659	0.0659
Onchocerca volvulus		0.0017	0.0832	0.4905
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0005	0.0078	0.0078
Echinococcus multilocularis	cysteine protease	0.0005	0.0078	0.0078
Onchocerca volvulus		0.003	0.1696	1
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0016	0.0808	0.0808
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0014	0.0659	0.0659
Brugia malayi	Cathepsin L-like precursor	0.0005	0.0078	0.0078
Onchocerca volvulus		0.0017	0.0832	0.4905
Entamoeba histolytica	hypothetical protein	0.0016	0.0808	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0832	0.0832
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.003	0.1696	0.1696
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0005	0.0078	0.0078
Toxoplasma gondii	hypothetical protein	0.0017	0.0832	0.2342
Onchocerca volvulus		0.003	0.1696	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0005	0.0078	0.0078
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.003	0.1696	0.1696
Plasmodium falciparum	membrane associated erythrocyte binding-like protein	0.0013	0.0604	0.1634
Loa Loa (eye worm)	LGC-31 protein	0.003	0.1696	0.1696
Brugia malayi	PAN domain containing protein	0.0017	0.0832	0.0832
Schistosoma mansoni	nAChR subunit	0.003	0.1696	0.1696
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.003	0.1696	0.1696
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0005	0.0078	0.0078
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.003	0.1696	0.1696
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0005	0.0078	0.0078
Brugia malayi	Papain family cysteine protease containing protein	0.0005	0.0078	0.0078
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0014	0.0659	0.0659
Schistosoma mansoni	hypothetical protein	0.0026	0.1412	0.1412
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0005	0.0078	0.0078
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0016	0.0808	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0659	0.0659
Brugia malayi	Protein kinase domain containing protein	0.0026	0.1412	0.1412
Echinococcus granulosus	glycine receptor subunit alpha 1	0.003	0.1696	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0832	0.0832
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Schistosoma mansoni	nAChR subunit	0.0014	0.0659	0.0659
Loa Loa (eye worm)	PAN domain-containing protein	0.0017	0.0832	0.0832
Schistosoma mansoni	cathepsin F (C01 family)	0.0005	0.0078	0.0078
Brugia malayi	Cathepsin L-like precursor	0.0005	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1412	0.1412
Loa Loa (eye worm)	fibroinase	0.0005	0.0078	0.0078
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.003	0.1696	0.1696
Toxoplasma gondii	apical membrane antigen 1 domain-containing protein	0.0055	0.3297	1
Echinococcus granulosus	glycine receptor subunit beta	0.003	0.1696	0.1696
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0078	0.0078
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.003	0.1696	0.1696
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.003	0.1696	0.1696
Echinococcus multilocularis	glycine receptor subunit beta	0.003	0.1696	0.1696
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.003	0.1696	0.1696
Brugia malayi	Cation transporter family protein	0.003	0.1696	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0659	0.0659
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0005	0.0078	0.0078
Plasmodium falciparum	cysteine repeat modular protein 1	0.0026	0.1412	0.4142
Giardia lamblia	Cathepsin B precursor	0.0053	0.3147	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.003	0.1696	0.1696
Toxoplasma gondii	apical membrane antigen 1 protein	0.0013	0.0604	0.1634
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0078	0.0078
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.003	0.1696	0.1696
Echinococcus granulosus	cathepsin L cysteine protease	0.0005	0.0078	0.0078
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0026	0.1412	0.4142
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Toxoplasma gondii	hypothetical protein	0.0017	0.0832	0.2342
Echinococcus granulosus	cathepsin l1	0.0005	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0659	0.0659
Brugia malayi	hypothetical protein	0.0014	0.0659	0.0659
Brugia malayi	Cathepsin L-like precursor	0.0005	0.0078	0.0078
Brugia malayi	PAN domain containing protein	0.0017	0.0832	0.0832
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0005	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0808	0.0808
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.003	0.1696	0.1696
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0808	0.0808
Toxoplasma gondii	microneme protein MIC17B	0.0017	0.0832	0.2342
Onchocerca volvulus		0.0017	0.0832	0.4905
Toxoplasma gondii	PAN domain-containing protein	0.0017	0.0832	0.2342
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0005	0.0078	0.0078
Onchocerca volvulus	Cathepsin L homolog	0.0005	0.0078	0.046
Schistosoma mansoni	acetylcholine receptor-related	0.0014	0.0659	0.0659
Schistosoma mansoni	neurotransmitter gated ion channel	0.0014	0.0659	0.0659
Brugia malayi	hypothetical protein	0.0014	0.0659	0.0659
Brugia malayi	cathepsin L precursor	0.0005	0.0078	0.0078
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0016	0.0808	0.0808
Loa Loa (eye worm)	PAN domain-containing protein	0.0017	0.0832	0.0832
Plasmodium vivax	apical membrane antigen 1	0.0055	0.3297	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0005	0.0078	0.0078
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0014	0.0659	0.0659
Brugia malayi	PAN domain containing protein	0.0017	0.0832	0.0832
Onchocerca volvulus		0.0017	0.0832	0.4905
Echinococcus granulosus	glycine receptor subunit beta	0.003	0.1696	0.1696
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.016	1	1
Loa Loa (eye worm)	ACC-1 protein	0.003	0.1696	0.1696
Echinococcus granulosus	cysteine protease	0.0005	0.0078	0.0078
Echinococcus granulosus	cathepsin L	0.0005	0.0078	0.0078
Onchocerca volvulus		0.0017	0.0832	0.4905
Schistosoma mansoni	cathepsin S (C01 family)	0.0005	0.0078	0.0078
Toxoplasma gondii	apical membrane antigen AMA1	0.0013	0.0604	0.1634
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.003	0.1696	0.1696
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0016	0.0823	0.0823
Brugia malayi	Kringle domain containing protein	0.0026	0.1412	0.1412
Brugia malayi	PAN domain containing protein	0.0017	0.0832	0.0832
Brugia malayi	Papain family cysteine protease containing protein	0.0005	0.0078	0.0078
Echinococcus multilocularis	nAChR subunit	0.0016	0.0808	0.0808
Loa Loa (eye worm)	hypothetical protein	0.003	0.1696	0.1696
Brugia malayi	Papain family cysteine protease containing protein	0.0005	0.0078	0.0078
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.003	0.1696	0.1696
Toxoplasma gondii	microneme protein, putative	0.0017	0.0832	0.2342
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0832	0.0832
Toxoplasma gondii	microneme protein MIC17C	0.0017	0.0832	0.2342
Schistosoma mansoni	cathepsin F (C01 family)	0.0005	0.0078	0.0078
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0005	0.0078	0.0078
Onchocerca volvulus		0.0017	0.0832	0.4905
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.003	0.1696	0.1696
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.003	0.1696	0.1696
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.003	0.1696	0.1696
Onchocerca volvulus		0.0017	0.0832	0.4905

Activities

Activity type	Activity value	Assay description	Source	Reference
Efficacy (functional)	= 4 %	Agonist activity at recombinant GABAA receptor subunit alpha-1 expressed in CHO cells at 3 uM by sensitive fluorometric read-out assay relative to midazolam	ChEMBL.	21277199
Efficacy (functional)	= 23 %	Agonist activity at recombinant GABAA receptor subunit alpha-2 expressed in CHO cells at 3 uM by sensitive fluorometric read-out assay relative to midazolam	ChEMBL.	21277199
IC50 (binding)	= 67 nM	Displacement of [3H]flumazenil from GABAA receptor subunit alpha-1 expressed in CHO cells	ChEMBL.	21277199
IC50 (binding)	= 213 nM	Displacement of [3H]flumazenil from GABAA receptor subunit alpha-2 expressed in CHO cells	ChEMBL.	21277199

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1681892

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1503670