Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0376 | 0.0005 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.3839 | 1 | 1 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0376 | 0.0005 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0376 | 0.0005 | 1 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0376 | 0.0005 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.1122 | 0.2159 | 1 |
Onchocerca volvulus | 0.3839 | 1 | 1 | |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0376 | 0.0005 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.3463 | 0.8915 | 0.8914 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0376 | 0.0005 | 0.0025 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0376 | 0.0005 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0376 | 0.0005 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.3839 | 1 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0376 | 0.0005 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.3463 | 0.8915 | 0.5 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0376 | 0.0005 | 0.5 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0376 | 0.0005 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0376 | 0.0005 | 1 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0376 | 0.0005 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.3463 | 0.8915 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0376 | 0.0005 | 0.0025 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.3463 | 0.8915 | 0.8914 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0376 | 0.0005 | 0.0025 |
Schistosoma mansoni | fatty acid desaturase | 0.0376 | 0.0005 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0376 | 0.0005 | 1 |
Onchocerca volvulus | 0.3839 | 1 | 1 | |
Brugia malayi | acyl-CoA desaturase | 0.3463 | 0.8915 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.3463 | 0.8915 | 1 |
Leishmania major | fatty-acid desaturase, putative | 0.3839 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 23.35 uM | Antimalarial activity against chloroquine-susceptible Plasmodium berghei ANKA infected in Balb-C mouse | ChEMBL. | 21334900 |
Inhibition (functional) | = 27.4 % | Antimalarial activity against chloroquine-susceptible Plasmodium berghei ANKA infected in Balb-C mouse assessed as inhibition parasitemia at 20 mg/kg, ip qd for 4 days administered fourth day post infection | ChEMBL. | 21334900 |
Inhibition (functional) | = 33.75 % | Antimalarial activity against chloroquine-susceptible Plasmodium berghei ANKA assessed as inhibition of trophozoite extract-mediated mouse hemoglobin hydrolysis at 10 mM after 18 hrs by SDS-PAGE | ChEMBL. | 21334900 |
Survival (functional) | = 9.8 day | Antimalarial activity against chloroquine-susceptible Plasmodium berghei ANKA infected in Balb-C mouse assessed as mouse survival days at 20 mg/kg, ip qd for 4 days administered fourth day post infection relative to untreated control | ChEMBL. | 21334900 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.