TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 431.528 | Formula: C29H25N3O
H donors: 1 H acceptors: 1 LogP: 5.4 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Nc1ccc(cc1)CN1C(=O)[C@H](Cc2ccccc2)N=C(c2c1cccc2)c1ccccc1
InChi: 1S/C29H25N3O/c30-24-17-15-22(16-18-24)20-32-27-14-8-7-13-25(27)28(23-11-5-2-6-12-23)31-26(29(32)33)19-21-9-3-1-4-10-21/h1-18,26H,19-20,30H2/t26-/m0/s1
InChiKey: TTYDRONMYXXZIN-SANMLTNESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Brugia malayi	Liprin-alpha 2	0.0014	0.0114	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0164	0.1548	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0002	0.0015
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0002	0.0002	0.0014
Echinococcus granulosus	poly adp ribose polymerase 2	0.0023	0.0197	0.1272
Echinococcus granulosus	Ankyrin	0.0002	0.000000014591	0.00000009427
Trypanosoma cruzi	palmitoyl acyltransferase 1, putative	0.0002	0.0002	0.0014
Trichomonas vaginalis	serine/threonine-protein kinase ripk4, putative	0.0002	0	0.0001
Trichomonas vaginalis	conserved hypothetical protein	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0002	0.0014
Trichomonas vaginalis	tankyrase, putative	0.0002	0	0.0001
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin repeat-rich membrane-spanning protein, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0197	0.1272
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0114	0.0737
Giardia lamblia	Kinase, NEK	0.0002	0.0002	1
Echinococcus multilocularis	Ankyrin	0.0002	0.0002	0.0015
Echinococcus multilocularis	liprin beta 1	0.0014	0.0114	0.0737
Trichomonas vaginalis	D-aminoacylase, putative	0.0164	0.1548	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0164	0.1548	1
Trichomonas vaginalis	protein phosphatase 1 regulatory subunit 12B, putative	0.0002	0.000000014591	0.00000009427
Loa Loa (eye worm)	Notch2	0.0002	0	0.0001
Trichomonas vaginalis	ion channel nompc, putative	0.0002	0.000000014591	0.00000009427
Brugia malayi	beta-lactamase family protein	0.0164	0.1548	1
Brugia malayi	beta-lactamase	0.0164	0.1548	1
Trichomonas vaginalis	protein phosphatase 1 regulatory subunit 12C, putative	0.0002	0.0002	0.0014
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0002	0.000000014591	0.00000009427
Schistosoma mansoni	hypothetical protein	0.0014	0.0114	0.0737
Trichomonas vaginalis	26S proteasome non-ATPase regulatory subunit, putative	0.0002	0.000000014591	0.00000009427
Brugia malayi	WGR domain containing protein	0.0023	0.0197	0.1272
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0	0.0001
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0114	0.0737
Brugia malayi	beta-lactamase family protein	0.0164	0.1548	1
Trypanosoma brucei	beta lactamase	0.0294	0.2787	1
Entamoeba histolytica	hypothetical protein	0.0023	0.0197	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1132	0.7313
Mycobacterium leprae	PROBABLE CONSERVED LIPOPROTEIN LPQF	0.0294	0.2787	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0164	0.1548	1
Loa Loa (eye worm)	hypothetical protein	0.0164	0.1548	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0114	0.0737
Echinococcus multilocularis	26S proteasome non ATPase regulatory subunit 10	0.0002	0	0.0001
Trypanosoma cruzi	hypothetical protein, conserved	0.0164	0.1548	1
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0014	0.0114	0.0737
Entamoeba histolytica	zinc finger protein, putative	0.0023	0.0197	1
Trypanosoma cruzi	ankyrin repeat protein, putative	0.0002	0.000000014591	0.00000009427
Loa Loa (eye worm)	hypothetical protein	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0003	0.0008	0.0052
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0002	0.0014
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0023	0.0197	0.1272
Brugia malayi	Patatin-like phospholipase family protein	0.0002	0.0002	0.0014
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqF	0.0294	0.2787	0.1467
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0002	0.0014
Toxoplasma gondii	ABC1 family protein	0.0164	0.1548	1
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.0613	0.583	1
Trichomonas vaginalis	ankyrin repeat-rich membrane-spanning protein, putative	0.0002	0	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0002	0.000000014591	0.00000009427
Echinococcus granulosus	beta LACTamase domain containing family member	0.0164	0.1548	1
Trichomonas vaginalis	2-5A-dependent ribonuclease, putative	0.0002	0.0002	0.0014
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0014	0.0114	0.0737
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0164	0.1548	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	rolling pebbles, putative	0.0002	0.000000014591	0.00000009427
Giardia lamblia	Protein 21.1	0.0002	0.000000014591	0.0001
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0002	0.0002	0.0014
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0	0.0001
Echinococcus granulosus	Ankyrin	0.0002	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0002	0.0014
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0002	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0197	0.1272
Echinococcus multilocularis	stromal interaction molecule 1	0.0014	0.0114	0.0737
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0002	0.0014
Onchocerca volvulus		0.0164	0.1548	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Brugia malayi	coiled-coil like protein 1	0.0014	0.0114	0.0737
Onchocerca volvulus		0.0014	0.0114	0.0737
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0003	0.0006	0.0038
Trichomonas vaginalis	ankyrin repeat and sam domain-containing protein, putative	0.0002	0.000000014591	0.00000009427
Leishmania major	hypothetical protein, conserved	0.0164	0.1548	1
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0002	0.0002	0.0014
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0003	0.0006	0.0037
Giardia lamblia	Kinase, NEK	0.0002	0.0002	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0114	0.0737
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0	0.0001
Trichomonas vaginalis	E3 ubiquitin protein ligase, putative	0.0002	0	0.0001
Schistosoma mansoni	hypothetical protein	0.0014	0.0114	0.0737
Onchocerca volvulus	Tankyrase homolog	0.0143	0.1347	0.8705
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0002	0.0002	0.0014
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0023	0.0197	0.1272
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Trypanosoma cruzi	palmitoyl acyltransferase 1, putative	0.0002	0.0002	0.0014
Trichomonas vaginalis	penicillin-binding protein, putative	0.0164	0.1548	1
Brugia malayi	WGR domain containing protein	0.0023	0.0197	0.1272
Loa Loa (eye worm)	hypothetical protein	0.0164	0.1548	1
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0197	0.1272
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0023	0.0197	0.1272
Trichomonas vaginalis	fetal globin-inducing factor, putative	0.0002	0.000000014591	0.00000009427
Loa Loa (eye worm)	tnks protein	0.0146	0.137	0.8852
Loa Loa (eye worm)	beta-lactamase	0.0164	0.1548	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	esterase, putative	0.0164	0.1548	1
Giardia lamblia	Kinase, NEK-frag	0.0002	0.000000014591	0.0001
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Echinococcus multilocularis	tankyrase	0.016	0.1503	0.9711
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0023	0.0197	0.1272
Brugia malayi	Uncoordinated protein 44	0.0002	0	0.0001
Mycobacterium tuberculosis	Class a beta-lactamase BlaC	0.0613	0.583	0.5066
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0197	0.1272
Giardia lamblia	Protein 21.1	0.0002	0.000000014591	0.0001
Trichomonas vaginalis	ankyrin, putative	0.0002	0	0.0001
Brugia malayi	Leucine Rich Repeat family protein	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin, putative	0.0002	0.0002	0.0015
Trichomonas vaginalis	mind bomb, putative	0.0002	0.000000014591	0.00000009427
Mycobacterium ulcerans	lipoprotein LpqF	0.0294	0.2787	0.2895
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0	0.0001
Trichomonas vaginalis	cask-interacting protein (caskin) 1,2, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0197	0.1272
Trypanosoma brucei	poly(adp-ribose) polymerase	0.0023	0.0197	0.0706
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0023	0.0197	0.1272
Giardia lamblia	Kinase, NEK	0.0002	0.000000014591	0.0001
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.0023	0.0197	0.1272
Trichomonas vaginalis	multiple ankyrin repeats single kh domain protein, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	2-5A-dependent ribonuclease, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0197	0.1272
Leishmania major	huntingtin interacting protein (HIP), putative	0.0002	0.0002	0.0014
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0002	0.000000014591	0.00000009427
Brugia malayi	hypothetical protein	0.0014	0.0114	0.0737
Trichomonas vaginalis	ion channel nompc, putative	0.0002	0	0.0001
Plasmodium vivax	hypothetical protein, conserved	0.0164	0.1548	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0164	0.1548	1
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0002	0.000000014591	0.00000009427
Schistosoma mansoni	hypothetical protein	0.0014	0.0114	0.0737
Trichomonas vaginalis	ankyrin, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Entamoeba histolytica	hypothetical protein	0.0023	0.0197	1
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0197	0.1272
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0197	0.1272
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Plasmodium falciparum	protein kinase, putative	0.0014	0.0114	0.5
Schistosoma mansoni	ga binding protein beta chain (transcription factor e4tf1-47)	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin, putative	0.0002	0.0002	0.0014
Onchocerca volvulus		0.0164	0.1548	1
Trichomonas vaginalis	c2h2 zinc finger protein, putative	0.0014	0.0114	0.0737
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Giardia lamblia	Ankyrin 1	0.0002	0.000000014591	0.0001
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0002	0.0014
Echinococcus granulosus	tankyrase	0.016	0.1503	0.9711
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0023	0.0197	0.1272
Trichomonas vaginalis	multiple ankyrin repeats single kh domain protein, putative	0.0002	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0002	0.0002	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0114	0.0737
Echinococcus multilocularis	Ankyrin	0.0002	0.000000014591	0.00000009427
Schistosoma mansoni	hypothetical protein	0.0014	0.0114	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0114	0.0737
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0164	0.1548	1
Loa Loa (eye worm)	hypothetical protein	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Echinococcus multilocularis	liprin alpha 2	0.0014	0.0114	0.0737
Echinococcus multilocularis	SAM domain containing protein	0.0014	0.0114	0.0737
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Echinococcus granulosus	Sterile alpha motif SAM	0.0014	0.0114	0.0737
Trichomonas vaginalis	ankyrin, putative	0.0002	0	0.0001
Giardia lamblia	Kinase, NEK	0.0002	0.000000014591	0.0001
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0002	0.0002	0.0014
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0023	0.0197	0.1272
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0023	0.0197	0.1272
Trichomonas vaginalis	ankyrin repeat domain-containing protein, putative	0.0002	0	0.0001
Schistosoma mansoni	phospholipase	0.0002	0.000000014591	0.00000009427
Entamoeba histolytica	hypothetical protein	0.0023	0.0197	1
Trichomonas vaginalis	nf kappa B inhibitor I-kappa-B, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Onchocerca volvulus		0.0164	0.1548	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Plasmodium falciparum	tyrosine kinase-like protein	0.0014	0.0114	0.5
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0014	0.0114	0.0737
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0197	0.1272
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Loa Loa (eye worm)	hypothetical protein	0.0164	0.1548	1
Brugia malayi	hypothetical protein	0.0014	0.0114	0.0737
Trichomonas vaginalis	2-5A-dependent ribonuclease, putative	0.0002	0.000000014591	0.00000009427
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0164	0.1548	1
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0014	0.0114	0.0737
Trichomonas vaginalis	penicillin-binding protein, putative	0.0164	0.1548	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Echinococcus granulosus	liprin beta 1	0.0014	0.0114	0.0737
Trypanosoma brucei	hypothetical protein, conserved	0.0164	0.1548	0.5553
Entamoeba histolytica	hypothetical protein	0.0023	0.0197	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0114	0.0737
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0114	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0164	0.1548	1
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0002	0	0.0001
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0014	0.0114	0.0737
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0	0.0001
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0	0.0001
Echinococcus granulosus	stromal interaction molecule 1	0.0014	0.0114	0.0737
Echinococcus granulosus	26S proteasome non ATPase regulatory subunit 10	0.0002	0	0.0001
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0023	0.0197	1
Trichomonas vaginalis	cortactin-binding protein, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0002	0.0002	0.0014
Trichomonas vaginalis	ion channel nompc, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.000000014591	0.00000009427
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0023	0.0197	0.1272
Trichomonas vaginalis	protein phosphatase 1 regulatory subunit 12B, putative	0.0002	0	0.0001
Trichomonas vaginalis	ion channel nompc, putative	0.0002	0.0002	0.0014
Trichomonas vaginalis	inversin, putative	0.0002	0	0.0001
Entamoeba histolytica	ankyrin repeat protein, putative	0.0002	0.000000014591	0.0000007409
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0164	0.1548	1
Schistosoma mansoni	sarm1	0.0014	0.0114	0.0737
Trichomonas vaginalis	homeobox-containing protein wariai, putative	0.0002	0.000000014591	0.00000009427
Trichomonas vaginalis	fibronectin type 3 and ankyrin repeat domains, putative	0.0002	0.000000014591	0.00000009427
Brugia malayi	Neurabin protein 1	0.0014	0.0114	0.0737
Brugia malayi	Patatin-like phospholipase family protein	0.0002	0.000000014591	0.00000009427
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0014	0.0114	0.0737
Schistosoma mansoni	26S proteasome subunit	0.0002	0.000000014591	0.00000009427
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0164	0.1548	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0114	0.0737
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0197	0.1272
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0002	0.000000014591	0.00000009427
Echinococcus granulosus	liprin alpha 2	0.0014	0.0114	0.0737
Trypanosoma brucei	palmitoyl acyltransferase 1, putative	0.0002	0.0002	0.0008
Schistosoma mansoni	tankyrase	0.016	0.1505	0.9725
Echinococcus multilocularis	ankyrin repeat domain containing protein 6	0.0002	0.000000014591	0.00000009427
Onchocerca volvulus		0.0014	0.0114	0.0737
Echinococcus granulosus	SAM domain containing protein	0.0014	0.0114	0.0737
Brugia malayi	Tnks protein	0.0158	0.149	0.9627
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0014	0.0114	0.0737
Schistosoma mansoni	ankyrin 23/unc44	0.0002	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0164	0.1548	1
Trypanosoma brucei	Ankyrin repeats (many copies), putative	0.0002	0.000000014591	0.000000052344
Trichomonas vaginalis	ion channel nompc, putative	0.0002	0	0.0001
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0	0.0001
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0002	0.0002	0.0014

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1683728

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1504075