Detailed information for compound 1504640

Basic information

Technical information
  • TDR Targets ID: 1504640
  • Name: methyl 2-(4-chlorophenyl)-4-methyl-1,3-oxazol e-5-carboxylate
  • MW: 251.666 | Formula: C12H10ClNO3
  • H donors: 0 H acceptors: 2 LogP: 3.21 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1oc(nc1C)c1ccc(cc1)Cl
  • InChi: 1S/C12H10ClNO3/c1-7-10(12(15)16-2)17-11(14-7)8-3-5-9(13)6-4-8/h3-6H,1-2H3
  • InChiKey: UNHVMQJJXHJBRE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl 2-(4-chlorophenyl)-4-methyl-oxazole-5-carboxylate
  • 2-(4-chlorophenyl)-4-methyl-5-oxazolecarboxylic acid methyl ester
  • 2-(4-chlorophenyl)-4-methyl-oxazole-5-carboxylic acid methyl ester
  • MLS000721083
  • SMR000335271
  • ZINC01397932
  • 7L-355S

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor 0.0161 0.1599 0.3946
Brugia malayi nuclear receptor RXR 0.018 0.1862 0.226
Loa Loa (eye worm) hypothetical protein 0.0161 0.1599 0.1501
Echinococcus multilocularis beta LACTamase domain containing family member 0.0122 0.1067 0.2632
Loa Loa (eye worm) hypothetical protein 0.0341 0.4052 0.4641
Schistosoma mansoni nuclear receptor 0.0161 0.1599 0.3946
Echinococcus multilocularis nuclear receptor nhr 48 0.0161 0.1599 0.3946
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0341 0.4052 0.4918
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0122 0.1067 0.2632
Loa Loa (eye worm) hypothetical protein 0.0122 0.1067 0.082
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0341 0.4052 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0379 0.4572 0.5307
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0341 0.4052 0.7004
Brugia malayi Nuclear hormone receptor-like 1 0.018 0.1862 0.226
Loa Loa (eye worm) hypothetical protein 0.0161 0.1599 0.1501
Loa Loa (eye worm) fli-1 protein 0.0265 0.3022 0.3322
Schistosoma mansoni RAR-like nuclear receptor 0.0341 0.4052 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.1599 0.1501
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0161 0.1599 0.3946
Onchocerca volvulus 0.0341 0.4052 0.5011
Loa Loa (eye worm) hypothetical protein 0.0161 0.1599 0.1501
Echinococcus multilocularis ecdysone induced protein 78C 0.0341 0.4052 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0341 0.4052 0.7004
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0341 0.4052 1
Brugia malayi nuclear receptor NHR-88 0.0341 0.4052 0.4918
Loa Loa (eye worm) hypothetical protein 0.0161 0.1599 0.1501
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0341 0.4052 0.4918
Echinococcus granulosus Nuclear hormone receptor HR96 0.0161 0.1599 0.2764
Loa Loa (eye worm) hypothetical protein 0.018 0.1862 0.1838
Loa Loa (eye worm) hypothetical protein 0.0161 0.1599 0.1501
Loa Loa (eye worm) DR-78 0.0161 0.1599 0.1501
Brugia malayi Ets-domain containing protein 0.0087 0.0599 0.0727
Onchocerca volvulus 0.0161 0.1599 0.0894
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0161 0.1599 0.1941
Loa Loa (eye worm) hypothetical protein 0.0122 0.1067 0.082
Loa Loa (eye worm) hypothetical protein 0.0122 0.1067 0.082
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0341 0.4052 0.7004
Brugia malayi hypothetical protein 0.018 0.1862 0.226
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0341 0.4052 1
Brugia malayi beta-lactamase 0.0122 0.1067 0.1295
Loa Loa (eye worm) hypothetical protein 0.0218 0.2382 0.2503
Loa Loa (eye worm) hypothetical protein 0.0161 0.1599 0.1501
Brugia malayi orphan nuclear receptor NR2E1 0.0161 0.1599 0.1941
Brugia malayi ecdysone receptor 0.0161 0.1599 0.1941
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0341 0.4052 0.7004
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0291 0.3375 0.2584
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0341 0.4052 0.4641
Echinococcus granulosus thyroid hormone receptor alpha 0.0469 0.5785 1
Trichomonas vaginalis D-aminoacylase, putative 0.0122 0.1067 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0341 0.4052 0.7004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0341 0.4052 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0341 0.4052 0.4918
Schistosoma mansoni nuclear receptor nhr-48 0.0161 0.1599 0.3946
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0341 0.4052 0.7004
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0161 0.1599 0.3946
Brugia malayi Steroid receptor seven-up type 2 0.0341 0.4052 0.4918
Brugia malayi Ets-domain containing protein 0.0087 0.0599 0.0727
Mycobacterium ulcerans lipoprotein LpqF 0.0291 0.3375 0.3495
Brugia malayi nuclear hormone receptor 0.0379 0.4572 0.5549
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0341 0.4052 0.7004
Onchocerca volvulus 0.0161 0.1599 0.0894
Brugia malayi steroid hormone receptor 0.0649 0.8238 1
Brugia malayi beta-lactamase family protein 0.0122 0.1067 0.1295
Brugia malayi Nuclear hormone receptor E75 0.0161 0.1599 0.1941
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.018 0.1862 0.3218
Loa Loa (eye worm) steroid hormone receptor 0.0649 0.8238 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0341 0.4052 0.4918
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0341 0.4052 0.4918
Brugia malayi nuclear receptor RXR 0.0161 0.1599 0.1941
Schistosoma mansoni zinc finger protein 0.0161 0.1599 0.3946
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0607 0.7672 0.7394
Loa Loa (eye worm) hypothetical protein 0.018 0.1862 0.1838
Brugia malayi nuclear hormone receptor family member nhr-6 0.0161 0.1599 0.1941
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.018 0.1862 0.1838
Leishmania major hypothetical protein, conserved 0.0122 0.1067 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0341 0.4052 1
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0291 0.3375 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0161 0.1599 0.0894
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0341 0.4052 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0341 0.4052 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0341 0.4052 0.4918
Trypanosoma cruzi hypothetical protein, conserved 0.0122 0.1067 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0341 0.4052 0.4918
Loa Loa (eye worm) nuclear hormone receptor 0.0161 0.1599 0.1501
Trypanosoma cruzi hypothetical protein, conserved 0.0122 0.1067 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0341 0.4052 0.4918
Echinococcus granulosus ecdysone induced protein 78C 0.0341 0.4052 0.7004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0341 0.4052 0.4918
Loa Loa (eye worm) beta-lactamase 0.0122 0.1067 0.082
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.018 0.1862 0.4595
Trichomonas vaginalis D-aminoacylase, putative 0.0122 0.1067 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0122 0.1067 0.2632
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0341 0.4052 0.4641
Loa Loa (eye worm) hypothetical protein 0.0122 0.1067 0.082
Brugia malayi Nuclear hormone receptor E75 0.0161 0.1599 0.1941
Schistosoma mansoni gabp alpha 0.0087 0.0599 0.1478
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0161 0.1599 0.2764
Loa Loa (eye worm) hypothetical protein 0.0341 0.4052 0.4641
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0607 0.7672 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0161 0.1599 0.1501
Loa Loa (eye worm) hypothetical protein 0.0122 0.1067 0.082
Trichomonas vaginalis esterase, putative 0.0122 0.1067 0.5
Loa Loa (eye worm) hypothetical protein 0.0341 0.4052 0.4641
Schistosoma mansoni retinoid-x-receptor (RXR) 0.018 0.1862 0.4595
Brugia malayi beta-lactamase family protein 0.0122 0.1067 0.1295
Brugia malayi hypothetical protein 0.0161 0.1599 0.1941
Echinococcus multilocularis FTZ F1 alpha 0.0341 0.4052 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0341 0.4052 0.4918
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0341 0.4052 0.4641
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.056 0.7025 1
Schistosoma mansoni thyroid hormone receptor 0.0341 0.4052 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0341 0.4052 0.5011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0341 0.4052 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0341 0.4052 0.4641
Brugia malayi hypothetical protein 0.018 0.1862 0.226
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0341 0.4052 0.4918
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0161 0.1599 0.3946
Trichomonas vaginalis D-aminoacylase, putative 0.0122 0.1067 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0341 0.4052 0.4918
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.0599 0.1035
Brugia malayi Nuclear hormone receptor-like 1 0.018 0.1862 0.226
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0341 0.4052 0.4918
Schistosoma mansoni coup transcription factor 0.0341 0.4052 1
Schistosoma mansoni nuclear hormone receptor 0.0341 0.4052 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0161 0.1599 0.3946
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0341 0.4052 1
Loa Loa (eye worm) hypothetical protein 0.018 0.1862 0.1838
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0161 0.1599 0.2764
Brugia malayi tailless protein 0.0161 0.1599 0.1941
Loa Loa (eye worm) hypothetical protein 0.0161 0.1599 0.1501
Schistosoma mansoni nuclear receptor 0.0161 0.1599 0.3946
Loa Loa (eye worm) hypothetical protein 0.0341 0.4052 0.4641
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0341 0.4052 0.4918
Loa Loa (eye worm) hypothetical protein 0.0161 0.1599 0.1501
Toxoplasma gondii ABC1 family protein 0.0122 0.1067 0.5
Brugia malayi hypothetical protein 0.0161 0.1599 0.1941
Trichomonas vaginalis penicillin-binding protein, putative 0.0122 0.1067 0.5
Brugia malayi ecdysteroid receptor 0.0341 0.4052 0.4918
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.018 0.1862 0.4595
Brugia malayi nuclear hormone receptor 0.0341 0.4052 0.4918
Echinococcus multilocularis thyroid hormone receptor alpha 0.0341 0.4052 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0341 0.4052 1
Trypanosoma brucei beta lactamase 0.0291 0.3375 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.1599 0.1501
Echinococcus granulosus nuclear receptor nhr 48 0.0161 0.1599 0.2764
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.0599 0.0221
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0341 0.4052 0.4641
Loa Loa (eye worm) hypothetical protein 0.0341 0.4052 0.4641
Echinococcus granulosus beta LACTamase domain containing family member 0.0122 0.1067 0.1844
Loa Loa (eye worm) hypothetical protein 0.0161 0.1599 0.1501
Echinococcus granulosus Nuclear hormone receptor HR96 0.0161 0.1599 0.2764
Echinococcus granulosus FTZ F1 alpha 0.0341 0.4052 0.7004
Loa Loa (eye worm) hypothetical protein 0.0161 0.1599 0.1501
Loa Loa (eye worm) hypothetical protein 0.0341 0.4052 0.4641
Brugia malayi nuclear hormone receptor family member odr-7 0.0161 0.1599 0.1941
Brugia malayi conserved hypotetical protein 0.0161 0.1599 0.1941
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0161 0.1599 0.3946
Schistosoma mansoni steroid hormone receptor ad4bp 0.0341 0.4052 1
Schistosoma mansoni retinoic acid receptor RXR 0.0341 0.4052 1
Schistosoma mansoni nuclear hormone receptor 0.0161 0.1599 0.3946
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.0599 0.1478
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0341 0.4052 0.4641
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0122 0.1067 0.082
Loa Loa (eye worm) hypothetical protein 0.0341 0.4052 0.4641
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0341 0.4052 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.1067 0.082
Trichomonas vaginalis penicillin-binding protein, putative 0.0122 0.1067 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0341 0.4052 0.4918
Onchocerca volvulus Bile acid receptor homolog 0.0341 0.4052 0.5011
Brugia malayi nuclear receptor NHR-88 0.0161 0.1599 0.1941
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0161 0.1599 0.3946
Loa Loa (eye worm) hypothetical protein 0.018 0.1862 0.1838
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0161 0.1599 0.3946
Brugia malayi nuclear receptor NHR-67 0.0161 0.1599 0.1941
Plasmodium vivax hypothetical protein, conserved 0.0122 0.1067 0.5
Loa Loa (eye worm) hypothetical protein 0.0341 0.4052 0.4641
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0341 0.4052 0.4641
Loa Loa (eye worm) hypothetical protein 0.018 0.1862 0.1838
Brugia malayi Fli-1 protein 0.0265 0.3022 0.3668
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0122 0.1067 0.1295
Loa Loa (eye worm) hypothetical protein 0.0161 0.1599 0.1501
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0341 0.4052 1
Schistosoma mansoni ets-related 0.0265 0.3022 0.7457
Schistosoma mansoni thyroid hormone receptor 0.0341 0.4052 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0161 0.1599 0.0894

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0891 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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