Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ectonucleotide | 0.0205 | 0.0058 | 0.0058 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0205 | 0.0058 | 0.0058 |
Schistosoma mansoni | hypothetical protein | 0.0524 | 0.0864 | 0.0864 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.156 | 0.3478 | 1 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0338 | 0.0394 | 0.0394 |
Echinococcus multilocularis | ectonucleotide | 0.0205 | 0.0058 | 0.0058 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0191 | 0.0024 | 0.0024 |
Onchocerca volvulus | 0.0243 | 0.0154 | 0.0443 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0205 | 0.0058 | 0.0058 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0481 | 0.0755 | 0.217 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0243 | 0.0154 | 0.0154 |
Onchocerca volvulus | 0.0524 | 0.0864 | 0.2484 | |
Onchocerca volvulus | 0.0243 | 0.0154 | 0.0443 | |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.156 | 0.3478 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0243 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0191 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.0154 | 0.0154 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.156 | 0.3478 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0243 | 0.0154 | 0.0154 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0481 | 0.0755 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.0154 | 0.0154 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.156 | 0.3478 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0243 | 0.0154 | 0.0154 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0191 | 0.0024 | 0.0024 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0243 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.156 | 0.3478 | 0.3478 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0191 | 0.0024 | 0.0024 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.156 | 0.3478 | 0.3478 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0191 | 0.0024 | 0.0024 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.156 | 0.3478 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0524 | 0.0864 | 0.0864 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0243 | 0.0154 | 0.0154 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.156 | 0.3478 | 0.5 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0524 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 0.037 | 0.037 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.1079 | 0.2265 | 0.5 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0191 | 0.0024 | 0.0024 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0243 | 0.0154 | 0.0154 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0191 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.0154 | 0.0154 |
Onchocerca volvulus | 0.156 | 0.3478 | 1 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0243 | 0.0154 | 0.0154 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0191 | 0.0024 | 0.0024 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0243 | 0.0154 | 0.0154 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0481 | 0.0755 | 1 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.156 | 0.3478 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0243 | 0.0154 | 0.0154 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0191 | 0.0024 | 0.0024 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0481 | 0.0755 | 0.217 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0243 | 0.0154 | 0.0154 |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0191 | 0.0024 | 0.0024 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0191 | 0.0024 | 0.0024 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0191 | 0.0024 | 0.0024 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0243 | 0.0154 | 0.0154 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0243 | 0.0154 | 0.0154 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0481 | 0.0755 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0481 | 0.0755 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0243 | 0.0154 | 0.0154 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0191 | 0.0024 | 0.0024 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0243 | 0.0154 | 0.0154 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.156 | 0.3478 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.156 | 0.3478 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0191 | 0.0024 | 0.0024 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0191 | 0.0024 | 0.0024 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0243 | 0.0154 | 0.0154 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0191 | 0.0024 | 0.0024 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.156 | 0.3478 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0191 | 0.0024 | 0.0024 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 50 % | Anticonvulsant activity in albino CF-1 mouse assessed as protection against 6 Hz psychomotor seizure at 100 mg/kg, ip after 1 hr by minimal clonic seizure test | ChEMBL. | 21167624 |
Activity (functional) | = 75 % | Anticonvulsant activity in albino CF-1 mouse assessed as protection against 6 Hz psychomotor seizure at 100 mg/kg, ip after 0.25 hrs by minimal clonic seizure test | ChEMBL. | 21167624 |
Activity (functional) | = 100 mg kg-1 | Anticonvulsant activity in ip dosed albino CF-1 mouse assessed as dose required to protect against maximal electroshock-induced seizures after 2 hrs | ChEMBL. | 21167624 |
Activity (functional) | = 300 mg kg-1 | Anticonvulsant activity in ip dosed albino CF-1 mouse assessed as dose required to protect against maximal electroshock-induced seizures after 4 hrs | ChEMBL. | 21167624 |
ED50 (functional) | = 53.3 mg kg-1 | Anticonvulsant activity in ip dosed albino CF-1 mouse assessed as protection against 6 Hz psychomotor seizure after 0.25 hrs by minimal clonic seizure test | ChEMBL. | 21167624 |
ED50 (functional) | = 128.3 mg kg-1 | Anticonvulsant activity in ip dosed albino CF-1 mouse assessed as protection against maximal electroshock-induced seizures after 1 hr | ChEMBL. | 21167624 |
ED50 (functional) | > 250 mg kg-1 | Anticonvulsant activity in ipp dosed albino CF-1 mouse assessed as protection against subcutaneous metrazol-induced seizures after 1 hr | ChEMBL. | 21167624 |
ID50 (ADMET) | = 343.6 mg kg-1 | Neurotoxicity in ip dosed albino CF-1 mouse assessed as motor impairment after 8 hrs by rotarod test | ChEMBL. | 21167624 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.