Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0244 | 0.0203 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.0203 | 0.0203 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.1338 | 0.3279 | 1 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0181 | 0.0027 | 0.0027 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0244 | 0.0203 | 0.0203 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0181 | 0.0027 | 0.0027 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0244 | 0.0203 | 0.0203 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0413 | 0.0677 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.0203 | 0.0203 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.1338 | 0.3279 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0244 | 0.0203 | 0.0203 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.1338 | 0.3279 | 0.3279 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.1338 | 0.3279 | 0.3279 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0181 | 0.0027 | 0.0027 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0181 | 0.0027 | 0.0027 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.1338 | 0.3279 | 1 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.1338 | 0.3279 | 0.5 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0526 | 0.0997 | 0.0997 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0526 | 0.0997 | 0.0997 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0244 | 0.0203 | 0.0203 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0205 | 0.0095 | 0.0095 |
Schistosoma mansoni | hypothetical protein | 0.0526 | 0.0997 | 0.0997 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.1338 | 0.3279 | 1 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0329 | 0.0441 | 0.0441 |
Echinococcus granulosus | ectonucleotide | 0.0205 | 0.0095 | 0.0095 |
Onchocerca volvulus | 0.0244 | 0.0203 | 0.0619 | |
Echinococcus multilocularis | ectonucleotide | 0.0205 | 0.0095 | 0.0095 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0181 | 0.0027 | 0.0027 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0413 | 0.0677 | 0.2066 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0244 | 0.0203 | 0.0203 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0205 | 0.0095 | 0.0095 |
Onchocerca volvulus | 0.0244 | 0.0203 | 0.0619 | |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.1338 | 0.3279 | 1 |
Onchocerca volvulus | 0.0526 | 0.0997 | 0.304 | |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0181 | 0.0027 | 0.0027 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0413 | 0.0677 | 1 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.1338 | 0.3279 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0244 | 0.0203 | 0.0203 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0181 | 0.0027 | 0.0027 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0413 | 0.0677 | 0.2066 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0244 | 0.0203 | 0.0203 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0181 | 0.0027 | 0.0027 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.1338 | 0.3279 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0244 | 0.0203 | 0.0203 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0181 | 0.0027 | 0.0027 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0181 | 0.0027 | 0.0027 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0244 | 0.0203 | 0.0203 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0413 | 0.0677 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0244 | 0.0203 | 0.0203 |
Leishmania major | hypothetical protein, conserved | 0.0413 | 0.0677 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0244 | 0.0203 | 0.0203 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.1338 | 0.3279 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0181 | 0.0027 | 0.0027 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.1338 | 0.3279 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0181 | 0.0027 | 0.0027 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0181 | 0.0027 | 0.0027 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0244 | 0.0203 | 0.0203 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0181 | 0.0027 | 0.0027 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0181 | 0.0027 | 0.0027 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0244 | 0.0203 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.0415 | 0.0415 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0926 | 0.2119 | 0.5 |
Onchocerca volvulus | 0.1338 | 0.3279 | 1 | |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0181 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.0203 | 0.0203 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0244 | 0.0203 | 0.0203 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0244 | 0.0203 | 0.0203 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0181 | 0.0027 | 0.0027 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Anticonvulsant activity in albino CF-1 mouse assessed as protection against subcutaneous metrazol-induced seizures at 300 mg/kg, ip after 0.5 hrs | ChEMBL. | 21167624 | |
Activity (ADMET) | Neurotoxicity in albino CF-1 mouse assessed as motor impairment at 300 mg/kg, ip after 0.5 hrs by rotarod test | ChEMBL. | 21167624 | |
Activity (functional) | Anticonvulsant activity in albino CF-1 mouse assessed as protection against maximal electroshock-induced seizures at 300 mg/kg, ip after 2 hrs | ChEMBL. | 21167624 | |
Activity (ADMET) | Neurotoxicity in albino CF-1 mouse assessed as motor impairment at 300 mg/kg, ip after 4 hrs by rotarod test | ChEMBL. | 21167624 | |
Activity (functional) | Anticonvulsant activity in albino CF-1 mouse assessed as protection against 6 Hz psychomotor seizure at 100 mg/kg, ip after 2 hrs by minimal clonic seizure test | ChEMBL. | 21167624 | |
Activity (functional) | Anticonvulsant activity in albino CF-1 mouse assessed as protection against maximal electroshock-induced seizures at 300 mg/kg, ip after 0.5 hrs | ChEMBL. | 21167624 | |
Activity (functional) | Anticonvulsant activity in albino CF-1 mouse assessed as protection against 6 Hz psychomotor seizure at 100 mg/kg, ip after 0.5 hrs by minimal clonic seizure test | ChEMBL. | 21167624 | |
Activity (functional) | Anticonvulsant activity in albino CF-1 mouse assessed as protection against 6 Hz psychomotor seizure at 100 mg/kg, ip after 1 hr by minimal clonic seizure test | ChEMBL. | 21167624 | |
Activity (functional) | Anticonvulsant activity in albino CF-1 mouse assessed as protection against 6 Hz psychomotor seizure at 100 mg/kg, ip after 4 hrs by minimal clonic seizure test | ChEMBL. | 21167624 | |
Activity (functional) | Anticonvulsant activity in albino CF-1 mouse assessed as protection against maximal electroshock-induced seizures at 300 mg/kg, ip after 4 hrs | ChEMBL. | 21167624 | |
Activity (functional) | Anticonvulsant activity in albino CF-1 mouse assessed as protection against subcutaneous metrazol-induced seizures at 300 mg/kg, ip after 4 hrs | ChEMBL. | 21167624 | |
Activity (functional) | Anticonvulsant activity in albino CF-1 mouse assessed as protection against 6 Hz psychomotor seizure at 100 mg/kg, ip after 0.25 hrs by minimal clonic seizure test | ChEMBL. | 21167624 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.