TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 287.221 | Formula: C14H7F2N3O2
H donors: 1 H acceptors: 3 LogP: 3.45 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc2c(c1)n(c(n2)O)c1oc2c(n1)cccc2F
InChi: 1S/C14H7F2N3O2/c15-7-4-5-9-11(6-7)19(13(20)17-9)14-18-10-3-1-2-8(16)12(10)21-14/h1-6H,(H,17,20)
InChiKey: IMMPJABTWMVMPJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	gamma-aminobutyric acid (GABA) A receptor, alpha 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	gamma-aminobutyric acid (GABA) A receptor, alpha 2	451 aa	393 aa	25.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0053	0.0035
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0036	0.0008
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0053	1
Mycobacterium leprae	Isocitrate lyase	0.0795	0.4618	0.4618
Echinococcus granulosus	aldo keto reductase	0.0031	0.0053	0.0083
Leishmania major	aldo-keto reductase-like protein	0.0031	0.0053	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0031	0.0053	1
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0028	0.0036	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Schistosoma mansoni	protein tyrosine phosphatase	0.0028	0.0036	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0053	0.0083
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0028	0.0036	0.0056
Onchocerca volvulus		0.0031	0.0053	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Brugia malayi	hypothetical protein	0.0028	0.0036	0.0008
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Leishmania major	prostaglandin f synthase, putative	0.0031	0.0053	1
Echinococcus granulosus	hypothetical protein	0.0031	0.0053	0.0083
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0028	0.0036	0.0056
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0028	0.0036	0.0056
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0028	0.0036	0.0056
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0036	0.0056
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0036	0.0008
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.0053	0.0035
Schistosoma mansoni	protein tyrosine phosphatase	0.0028	0.0036	0.0008
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0028	0.0036	0.2388
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0036	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0028	0.0036	0.0008
Mycobacterium ulcerans	isocitrate lyase Icl	0.1696	1	1
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0031	0.0053	0.0053
Schistosoma mansoni	aldo-keto reductase	0.0031	0.0053	0.0035
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0028	0.0036	0.0008
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0028	0.0036	0.0008
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0028	0.0036	0.0056
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0028	0.0036	0.0008
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0053	0.0083
Echinococcus multilocularis	aldo keto reductase	0.0031	0.0053	0.0083
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0028	0.0036	0.0056
Mycobacterium tuberculosis	Isocitrate lyase Icl (isocitrase) (isocitratase)	0.1696	1	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0053	1
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0028	0.0036	0.0008
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0028	0.0036	0.0056
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0053	1
Entamoeba histolytica	aldose reductase, putative	0.0031	0.0053	1
Echinococcus multilocularis	carbonic anhydrase	0.0027	0.0031	0.0048
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0031	0.0053	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0028	0.0036	0.0056
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0028	0.0036	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0053	0.0035
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0053	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0031	0.0053	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0053	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0028	0.0036	0.0056
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0036	0.0056
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Echinococcus granulosus	carbonic anhydrase	0.0027	0.0031	0.0048
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0036	0.0008
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0053	0.0083
Trypanosoma cruzi	aldo-keto reductase	0.0031	0.0053	1
Brugia malayi	Protein-tyrosine phosphatase	0.0028	0.0036	0.0008
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0028	0.0036	0.0008
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0036	0.0008
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0036	0.0008
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0028	0.0036	0.0056
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0028	0.0036	0.0056
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0028	0.0036	0.0056
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0053	0.0083
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0036	0.0008
Echinococcus multilocularis	aldo keto reductase	0.0031	0.0053	0.0083
Mycobacterium tuberculosis	Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl)	0.1696	1	1
Entamoeba histolytica	aldose reductase, putative	0.0031	0.0053	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0036	0.0056
Brugia malayi	hypothetical protein	0.0028	0.0036	0.0008
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0036	0.0056
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.0053	0.0035
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0028	0.0036	0.0008
Trichomonas vaginalis	aldo/keto reductase, putative	0.0031	0.0053	1
Echinococcus multilocularis	aldo keto reductase	0.0031	0.0053	0.0083
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0053	0.0083
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.0053	0.0035
Onchocerca volvulus		0.0031	0.0053	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0028	0.0036	0.0056
Giardia lamblia	Aldose reductase	0.0031	0.0053	1
Schistosoma mansoni	aldo-keto reductase	0.0031	0.0053	0.0035
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0053	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0028	0.0036	0.0008
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0053	0.0083
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0028	0.0036	0.0056
Onchocerca volvulus		0.0031	0.0053	1
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0028	0.0036	0.0008
Leishmania major	tyrosine specific protein phosphatase, putative	0.0028	0.0036	0.2388
Brugia malayi	hypothetical protein	0.0028	0.0036	0.0008
Giardia lamblia	Aldose reductase	0.0031	0.0053	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0028	0.0036	0.0056
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0036	0.0056
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0036	0.0008
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0028	0.0036	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Plasmodium falciparum	carbonic anhydrase	0.0027	0.0031	0.5
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0053	0.0083
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0053	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1102	0.6454	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0053	0.0083
Trypanosoma brucei	prostaglandin f synthase	0.0031	0.0053	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0036	0.0008
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0053	0.0083
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0028	0.0036	0.0008
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0028	0.0036	0.2388
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0053	1
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0028	0.0036	0.0056
Trichomonas vaginalis	aldo/keto reductase, putative	0.0031	0.0053	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0053	0.0083
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1102	0.6454	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0053	0.0083
Entamoeba histolytica	aldose reductase, putative	0.0031	0.0053	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Echinococcus multilocularis		0.0028	0.0036	0.0056
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0053	0.0083
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0028	0.0036	0.0056
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0053	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0028	0.0036	0.0008
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0053	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0028	0.0036	0.0056
Onchocerca volvulus		0.0031	0.0053	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0028	0.0036	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0028	0.0036	0.2388
Brugia malayi	Protein-tyrosine phosphatase 1	0.0028	0.0036	0.0008
Trichomonas vaginalis	aldo/keto reductase, putative	0.0031	0.0053	1
Echinococcus multilocularis	carbonic anhydrase II	0.0027	0.0031	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0036	0.0008
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0028	0.0036	0.0008
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0028	0.0036	0.2388
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0036	0.0008
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0028	0.0036	0.0056
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0028	0.0036	0.0056
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0053	0.0083
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Echinococcus granulosus	carbonic anhydrase	0.0027	0.0031	0.0048
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0028	0.0036	0.0008
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Toxoplasma gondii	aldose reductase, putative	0.0031	0.0053	1
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0028	0.0036	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Onchocerca volvulus		0.0031	0.0053	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Echinococcus granulosus	carbonic anhydrase	0.0027	0.0031	0.0048
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0036	0.0008
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0028	0.0036	0.0008
Onchocerca volvulus		0.0031	0.0053	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0053	0.0035
Trypanosoma cruzi	aldo/keto reductase, putative	0.0031	0.0053	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0036	0.0008
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0053	1
Schistosoma mansoni	pol-related	0.0031	0.0053	0.0035
Trypanosoma brucei	aldo-keto reductase, putative	0.0031	0.0053	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0031	0.0053	0.0035
Echinococcus granulosus	carbonic anhydrase II	0.0027	0.0031	0.0048
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0031	0.0053	0.0083
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0028	0.0036	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Echinococcus multilocularis	carbonic anhydrase	0.0027	0.0031	0.0048
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0053	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0036	0.0008
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0053	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0053	0.0035
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0028	0.0036	0.0056
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0028	0.0036	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0053	0.0083
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0028	0.0036	0.0008
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0053	0.0083
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0036	0.0056
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0028	0.0036	0.0008
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0028	0.0036	0.0056
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0053	1
Echinococcus multilocularis	aldo keto reductase	0.0031	0.0053	0.0083
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0031	0.0053	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0028	0.0036	0.0056
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0028	0.0036	0.2388
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0031	0.0053	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1102	0.6454	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1102	0.6454	1
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0028	0.0036	0.0008
Echinococcus granulosus	aldo keto reductase	0.0031	0.0053	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Mycobacterium ulcerans	isocitrate lyase AceAb	0.1696	1	1
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0028	0.0036	0.0008
Mycobacterium tuberculosis	Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl)	0.1696	1	1
Schistosoma mansoni	pcd6 interacting protein-related	0.0028	0.0036	0.0008
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0036	0.0008
Echinococcus granulosus	aldo keto reductase	0.0031	0.0053	0.0083
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0028	0.0036	0.0056
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0028	0.0036	0.0056
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.1102	0.6454	1
Brugia malayi	hypothetical protein	0.0028	0.0036	0.0008
Brugia malayi	hypothetical protein	0.0028	0.0036	0.0008
Echinococcus multilocularis	hypothetical protein	0.0028	0.0036	0.0056
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0031	0.0053	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0028	0.0036	0.0056
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0036	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0053	0.0035
Echinococcus multilocularis	carbonic anhydrase	0.0027	0.0031	0.0048
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0028	0.0036	0.0056
Brugia malayi	Protein-tyrosine phosphatase	0.0028	0.0036	0.0008
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0028	0.0036	0.0056
Trichomonas vaginalis	aldo-keto reductase, putative	0.0031	0.0053	1
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0028	0.0036	0.0056
Loa Loa (eye worm)	oxidoreductase	0.0031	0.0053	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0036	0.0008

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 15 nM	Binding affinity against GABA-A benzodiazepine receptor	ChEMBL.	11133077
Ki (binding)	= 15 nM	Binding affinity against GABA-A benzodiazepine receptor	ChEMBL.	11133077

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 150652