Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cell adhesion molecule | 0.0073 | 0.194 | 0.2407 |
Schistosoma mansoni | nephrin | 0.0121 | 0.8018 | 0.9949 |
Schistosoma mansoni | ephrin receptor | 0.0075 | 0.2163 | 0.2684 |
Onchocerca volvulus | 0.0073 | 0.194 | 1 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0073 | 0.194 | 0.3192 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.194 | 0.2407 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0089 | 0.3922 | 0.3922 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0063 | 0.0703 | 0.0703 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0073 | 0.194 | 0.3192 |
Schistosoma mansoni | cell adhesion molecule | 0.0089 | 0.3922 | 0.4866 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0089 | 0.3922 | 0.6452 |
Schistosoma mansoni | myosin-binding protein-related | 0.0073 | 0.194 | 0.2407 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0089 | 0.3922 | 0.6452 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0073 | 0.194 | 0.3192 |
Echinococcus multilocularis | roundabout 2 | 0.0089 | 0.3922 | 0.3922 |
Schistosoma mansoni | hemicentin | 0.0073 | 0.194 | 0.2407 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.194 | 0.3192 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0089 | 0.3922 | 0.3922 |
Schistosoma mansoni | cell adhesion molecule | 0.0073 | 0.194 | 0.2407 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0089 | 0.3922 | 0.3922 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0073 | 0.194 | 0.194 |
Echinococcus granulosus | titin | 0.0073 | 0.194 | 0.194 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0073 | 0.194 | 0.3192 |
Echinococcus multilocularis | titin | 0.0073 | 0.194 | 0.194 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.6078 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0089 | 0.3922 | 0.4866 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0073 | 0.194 | 0.3192 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.2643 | 0.4349 |
Loa Loa (eye worm) | projectin | 0.0073 | 0.194 | 0.3192 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0703 | 0.1156 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.008 | 0.2866 | 0.4715 |
Schistosoma mansoni | nephrin | 0.0089 | 0.3922 | 0.4866 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0089 | 0.3922 | 0.3922 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0073 | 0.194 | 0.3192 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0073 | 0.194 | 0.3192 |
Echinococcus multilocularis | Down syndrome cell adhesion molecule | 0.0073 | 0.1982 | 0.1982 |
Schistosoma mansoni | titin | 0.0073 | 0.194 | 0.2407 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0089 | 0.3922 | 0.6452 |
Echinococcus granulosus | titin | 0.0073 | 0.194 | 0.194 |
Schistosoma mansoni | titin | 0.0073 | 0.194 | 0.2407 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0089 | 0.3922 | 0.4866 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.6078 | 1 |
Echinococcus multilocularis | neuroglian | 0.0089 | 0.3922 | 0.3922 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.2643 | 0.4349 |
Echinococcus multilocularis | neuroglian | 0.0063 | 0.0662 | 0.0662 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0073 | 0.194 | 0.3192 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0106 | 0.6078 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0075 | 0.2163 | 0.2163 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0073 | 0.194 | 0.3192 |
Echinococcus granulosus | Down syndrome cell adhesion molecule | 0.0073 | 0.1982 | 0.1982 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0075 | 0.2163 | 0.2163 |
Onchocerca volvulus | 0.0073 | 0.194 | 1 | |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0089 | 0.3922 | 0.3922 |
Schistosoma mansoni | neuroglian | 0.0089 | 0.3922 | 0.4866 |
Echinococcus granulosus | neuroglian | 0.0089 | 0.3922 | 0.3922 |
Echinococcus multilocularis | roundabout 2 | 0.0089 | 0.3922 | 0.3922 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0073 | 0.194 | 0.3192 |
Brugia malayi | hypothetical protein | 0.0106 | 0.6078 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0121 | 0.806 | 1 |
Echinococcus granulosus | nephrin | 0.0073 | 0.194 | 0.194 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.6078 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0073 | 0.194 | 0.2407 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.008 | 0.2866 | 0.4715 |
Brugia malayi | protein unc-22 | 0.0073 | 0.194 | 0.3192 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0073 | 0.194 | 0.3192 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0073 | 0.1982 | 0.326 |
Onchocerca volvulus | 0.0073 | 0.194 | 1 | |
Echinococcus granulosus | roundabout 2 | 0.0089 | 0.3922 | 0.3922 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0089 | 0.3922 | 0.6452 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0106 | 0.6078 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0073 | 0.1982 | 0.326 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0089 | 0.3922 | 0.6452 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.3922 | 0.6452 |
Echinococcus granulosus | roundabout 2 | 0.0089 | 0.3922 | 0.3922 |
Echinococcus granulosus | twitchin | 0.0063 | 0.0662 | 0.0662 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.194 | 0.3192 |
Echinococcus granulosus | contactin | 0.0089 | 0.3922 | 0.3922 |
Echinococcus multilocularis | transfer RNA-Phe | 0.0073 | 0.194 | 0.194 |
Echinococcus granulosus | neuroglian | 0.0063 | 0.0662 | 0.0662 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0073 | 0.194 | 0.3192 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.62 | Inhibition of Human immunodeficiency virus 1 integrase strand transfer activity after 30 mins by polyacrylamide gel electrophoresis | ChEMBL. | 21371895 |
IC50 (binding) | = 24 uM | Inhibition of Human immunodeficiency virus 1 integrase strand transfer activity after 30 mins by polyacrylamide gel electrophoresis | ChEMBL. | 21371895 |
IC50 (binding) | = 52 uM | Inhibition of Human immunodeficiency virus 1 integrase-mediated 3'-processing after 30 mins by polyacrylamide gel electrophoresis | ChEMBL. | 21371895 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.