Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | myosin-binding protein-related | 0.0068 | 0.1603 | 0.1909 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0071 | 0.1914 | 0.1914 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0086 | 0.3668 | 0.4368 |
Echinococcus granulosus | roundabout 2 | 0.0086 | 0.3668 | 0.3668 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3517 | 0.5553 |
Echinococcus multilocularis | Down syndrome cell adhesion molecule | 0.0072 | 0.2064 | 0.2064 |
Echinococcus granulosus | titin | 0.0068 | 0.1603 | 0.1603 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0068 | 0.1603 | 0.2532 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0068 | 0.1603 | 0.2532 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.1603 | 0.1909 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0072 | 0.2064 | 0.326 |
Echinococcus multilocularis | neuroglian | 0.0086 | 0.3668 | 0.3668 |
Schistosoma mansoni | cell adhesion molecule | 0.0125 | 0.8397 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1603 | 0.2532 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0068 | 0.1603 | 0.2532 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.6332 | 1 |
Echinococcus granulosus | twitchin | 0.0067 | 0.1452 | 0.1452 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0068 | 0.1603 | 0.2532 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0068 | 0.1603 | 0.2532 |
Echinococcus granulosus | neuroglian | 0.0067 | 0.1452 | 0.1452 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0068 | 0.1603 | 0.2532 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1603 | 0.2532 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0086 | 0.3668 | 0.3668 |
Schistosoma mansoni | cell adhesion molecule | 0.0086 | 0.3668 | 0.4368 |
Onchocerca volvulus | 0.0068 | 0.1603 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.3668 | 0.5792 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0086 | 0.3668 | 0.3668 |
Onchocerca volvulus | 0.0068 | 0.1603 | 1 | |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0086 | 0.3668 | 0.5792 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0068 | 0.1603 | 0.2532 |
Schistosoma mansoni | nephrin | 0.0086 | 0.3668 | 0.4368 |
Brugia malayi | hypothetical protein | 0.0108 | 0.6332 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0068 | 0.1603 | 0.1909 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1914 | 0.3022 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0068 | 0.1603 | 0.1603 |
Echinococcus granulosus | nephrin | 0.0068 | 0.1603 | 0.1603 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0068 | 0.1603 | 0.2532 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0086 | 0.3668 | 0.5792 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0108 | 0.6332 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0086 | 0.3668 | 0.3668 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0086 | 0.3668 | 0.5792 |
Schistosoma mansoni | cell adhesion molecule | 0.0086 | 0.3668 | 0.4368 |
Schistosoma mansoni | hemicentin | 0.0068 | 0.1603 | 0.1909 |
Schistosoma mansoni | titin | 0.0068 | 0.1603 | 0.1909 |
Echinococcus multilocularis | titin | 0.0068 | 0.1603 | 0.1603 |
Schistosoma mansoni | neuroglian | 0.0086 | 0.3668 | 0.4368 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0068 | 0.1603 | 0.2532 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0071 | 0.1906 | 0.1906 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0087 | 0.382 | 0.6032 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0086 | 0.3668 | 0.5792 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.6332 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0068 | 0.1603 | 0.1909 |
Schistosoma mansoni | ephrin receptor | 0.0071 | 0.1906 | 0.227 |
Schistosoma mansoni | titin | 0.0068 | 0.1603 | 0.1909 |
Loa Loa (eye worm) | projectin | 0.0068 | 0.1603 | 0.2532 |
Echinococcus granulosus | titin | 0.0068 | 0.1603 | 0.1603 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0086 | 0.3668 | 0.5792 |
Brugia malayi | protein unc-22 | 0.0068 | 0.1603 | 0.2532 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0086 | 0.3668 | 0.3668 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0087 | 0.382 | 0.6032 |
Echinococcus multilocularis | neuroglian | 0.0067 | 0.1452 | 0.1452 |
Echinococcus granulosus | neuroglian | 0.0086 | 0.3668 | 0.3668 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0068 | 0.1603 | 0.2532 |
Schistosoma mansoni | cell adhesion molecule | 0.0068 | 0.1603 | 0.1909 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0071 | 0.1906 | 0.1906 |
Echinococcus granulosus | roundabout 2 | 0.0086 | 0.3668 | 0.3668 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.6332 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0072 | 0.2064 | 0.326 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0068 | 0.1603 | 0.2532 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0086 | 0.3668 | 0.3668 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0108 | 0.6332 | 1 |
Echinococcus granulosus | Down syndrome cell adhesion molecule | 0.0072 | 0.2064 | 0.2064 |
Onchocerca volvulus | 0.0068 | 0.1603 | 1 | |
Echinococcus multilocularis | roundabout 2 | 0.0086 | 0.3668 | 0.3668 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0068 | 0.1603 | 0.2532 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0086 | 0.3668 | 0.3668 |
Schistosoma mansoni | nephrin | 0.0121 | 0.7936 | 0.9451 |
Echinococcus granulosus | contactin | 0.0086 | 0.3668 | 0.3668 |
Echinococcus multilocularis | transfer RNA-Phe | 0.0068 | 0.1603 | 0.1603 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3517 | 0.5553 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | > 256 ug ml-1 | Antifungal activity against Candida albicans ATCC 90027 after 48 hrs by broth microdilution method | ChEMBL. | 21277200 |
MIC (functional) | > 256 ug ml-1 | Antitubercular activity against multidrug-resistant Mycobacterium tuberculosis H37Rv after 7 days by alamar blue assay | ChEMBL. | 21277200 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.