Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0058 | 0.045 | 0.054 |
Echinococcus granulosus | acetylcholinesterase | 0.0341 | 0.6472 | 0.8196 |
Chlamydia trachomatis | chorismate synthase | 0.0204 | 0.3559 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0341 | 0.6472 | 0.8196 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0341 | 0.6472 | 0.8202 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 0.0978 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0068 | 0.0664 | 0.0812 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0041 | 0.009 | 0.0114 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0127 | 0.1932 | 0.2448 |
Schistosoma mansoni | acetylcholinesterase | 0.0058 | 0.045 | 0.054 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 0.0978 | 1 |
Toxoplasma gondii | chorismate synthase, putative | 0.0204 | 0.3559 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0058 | 0.045 | 0.054 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.0507 | 1 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0408 | 0.789 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0041 | 0.009 | 0.0083 |
Entamoeba histolytica | protein kinase, putative | 0.0082 | 0.0978 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0038 | 0.0025 | 0.0032 |
Trypanosoma brucei | protein kinase, putative | 0.0082 | 0.0978 | 1 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.0507 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0058 | 0.045 | 0.4459 |
Brugia malayi | hypothetical protein | 0.0058 | 0.045 | 0.054 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0082 | 0.0978 | 0.2695 |
Echinococcus multilocularis | 0.0039 | 0.0063 | 0.0048 | |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0082 | 0.0978 | 0.1211 |
Schistosoma mansoni | tyrosine kinase | 0.0068 | 0.0664 | 0.0812 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.0507 | 1 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0041 | 0.009 | 0.0083 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0082 | 0.0978 | 0.1211 |
Echinococcus granulosus | protein kinase shaggy | 0.0082 | 0.0978 | 0.1211 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.6472 | 0.8202 |
Schistosoma mansoni | tyrosine kinase | 0.0127 | 0.1932 | 0.2424 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0127 | 0.1932 | 0.2424 |
Schistosoma mansoni | gliotactin | 0.0058 | 0.045 | 0.054 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0082 | 0.0978 | 0.2695 |
Giardia lamblia | Kinase, CMGC GSK | 0.0082 | 0.0978 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0058 | 0.045 | 0.054 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0082 | 0.0978 | 0.1211 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0341 | 0.6472 | 0.8196 |
Mycobacterium ulcerans | chorismate synthase | 0.0204 | 0.3559 | 0.3256 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0058 | 0.045 | 0.054 |
Giardia lamblia | Kinase, CMGC GSK | 0.0082 | 0.0978 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0058 | 0.045 | 0.054 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0082 | 0.0978 | 0.2695 |
Mycobacterium tuberculosis | Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) | 0.0101 | 0.1362 | 0.0956 |
Echinococcus multilocularis | acetylcholinesterase | 0.0341 | 0.6472 | 0.8196 |
Brugia malayi | intracellular kinase | 0.0082 | 0.0978 | 0.1211 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0058 | 0.045 | 0.054 |
Plasmodium vivax | chorismate synthase | 0.0204 | 0.3559 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0068 | 0.0679 | 0.0832 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0068 | 0.0679 | 0.0832 |
Plasmodium falciparum | chorismate synthase | 0.0204 | 0.3559 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0082 | 0.0978 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0058 | 0.045 | 0.054 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0341 | 0.6472 | 0.8196 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0068 | 0.0679 | 0.0832 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0058 | 0.045 | 0.054 |
Echinococcus granulosus | neuroligin | 0.0058 | 0.045 | 0.054 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0127 | 0.1932 | 0.2424 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0038 | 0.0025 | 0.0032 |
Schistosoma mansoni | tyrosine kinase | 0.0068 | 0.0679 | 0.0832 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0082 | 0.0978 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0341 | 0.6472 | 0.8196 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0082 | 0.0978 | 0.1239 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Brugia malayi | Carboxylesterase family protein | 0.0058 | 0.045 | 0.054 |
Echinococcus multilocularis | insulin receptor | 0.0041 | 0.009 | 0.0083 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0058 | 0.045 | 0.054 |
Schistosoma mansoni | tyrosine kinase | 0.0041 | 0.009 | 0.0083 |
Brugia malayi | Carboxylesterase family protein | 0.0341 | 0.6472 | 0.8196 |
Onchocerca volvulus | 0.0082 | 0.0978 | 1 | |
Echinococcus multilocularis | neuroligin | 0.0058 | 0.045 | 0.054 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.045 | 0.057 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0082 | 0.0978 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0408 | 0.789 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0408 | 0.789 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0408 | 0.789 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0408 | 0.789 | 1 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.0507 | 1 | 1 |
Mycobacterium leprae | Isocitrate lyase | 0.0238 | 0.4276 | 0.3373 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0127 | 0.1932 | 0.2424 |
Brugia malayi | Carboxylesterase family protein | 0.0058 | 0.045 | 0.054 |
Echinococcus granulosus | insulin receptor | 0.0041 | 0.009 | 0.0083 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0058 | 0.045 | 0.054 |
Loa Loa (eye worm) | carboxylesterase | 0.0058 | 0.045 | 0.057 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0058 | 0.045 | 0.054 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0038 | 0.0025 | 0.0032 |
Loa Loa (eye worm) | carboxylesterase | 0.0058 | 0.045 | 0.057 |
Schistosoma mansoni | tyrosine kinase | 0.0041 | 0.009 | 0.0083 |
Brugia malayi | Protein kinase domain containing protein | 0.0041 | 0.009 | 0.0083 |
Loa Loa (eye worm) | carboxylesterase | 0.0341 | 0.6472 | 0.8202 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0068 | 0.0679 | 0.0832 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0058 | 0.045 | 0.054 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.6472 | 0.8202 |
Echinococcus multilocularis | acetylcholinesterase | 0.0341 | 0.6472 | 0.8196 |
Schistosoma mansoni | tyrosine kinase | 0.0068 | 0.0664 | 0.0812 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0082 | 0.0978 | 0.1239 |
Echinococcus multilocularis | protein kinase shaggy | 0.0082 | 0.0978 | 0.1211 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0082 | 0.0978 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0341 | 0.6472 | 0.8196 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.0507 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0058 | 0.045 | 0.054 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0058 | 0.045 | 0.4459 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Very weak inhibition 0 uM | Compound was tested for inhibition of interleukin-6-dependent MH60 cell growth; Very weak inhibition | ChEMBL. | 15109670 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.