TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 321.413 | Formula: C21H23NO2
H donors: 1 H acceptors: 1 LogP: 3.77 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc2c1CC(CC2)C(=O)N[C@H]1C[C@@H]1c1ccccc1
InChi: 1S/C21H23NO2/c1-24-20-9-5-8-15-10-11-16(12-18(15)20)21(23)22-19-13-17(19)14-6-3-2-4-7-14/h2-9,16-17,19H,10-13H2,1H3,(H,22,23)/t16?,17-,19+/m1/s1
InChiKey: GWFJJCPRJHUFIT-QIONWKSUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Epoxide hydrolase 2	Starlite/ChEMBL	References
Homo sapiens	cytochrome P450, family 2, subfamily C, polypeptide 19	Starlite/ChEMBL	References
Homo sapiens	epoxide hydrolase 2, cytoplasmic	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	Get druggable targets OG5_129061	All targets in OG5_129061
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582
Mycobacterium ulcerans	epoxide hydrolase EphA	Get druggable targets OG5_129061	All targets in OG5_129061

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania major	cytochrome p450-like protein	cytochrome P450, family 2, subfamily C, polypeptide 19	490 aa	411 aa	23.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	jumonji/arid domain-containing protein	0.045	0.0795	0.0795
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0332	0.0502	0.0969
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0332	0.0502	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0056	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0056	0.0108
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0332	0.0502	0.0969
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0332	0.0502	0.0969
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0153	0.0056	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0717	0.1458	0.2815
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0502	0.0969
Schistosoma mansoni	nAChR subunit	0.0332	0.0502	0.0502
Brugia malayi	Cation transporter family protein	0.0332	0.0502	0.0969
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0552	0.1049	0.1762
Onchocerca volvulus	Putative nachr subunit	0.0332	0.0502	0.087
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0332	0.0502	0.0843
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0332	0.0502	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0179	0.012	0.0232
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0153	0.0056	0.0056
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0332	0.0502	0.0843
Schistosoma mansoni	nAChR subunit	0.0332	0.0502	0.0502
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0502	0.0969
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0332	0.0502	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0502	0.0969
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0332	0.0502	0.0843
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0332	0.0502	0.0843
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0332	0.0502	0.0843
Echinococcus granulosus	SAM and MBT domain containing protein	0.1862	0.4308	0.7239
Loa Loa (eye worm)	hypothetical protein	0.0179	0.012	0.0232
Echinococcus multilocularis	histone acetyltransferase myst3	0.0197	0.0165	0.0277
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0153	0.0056	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0502	0.0969
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0179	0.012	0.012
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.2523	0.5951	1
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0464	0.0828	0.1392
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0332	0.0502	0.0843
Loa Loa (eye worm)	hypothetical protein	0.087	0.1839	0.3552
Loa Loa (eye worm)	hypothetical protein	0.0179	0.012	0.0232
Echinococcus multilocularis	chromobox protein 2	0.0954	0.2047	0.3441
Echinococcus granulosus	histone acetyltransferase MYST2	0.0464	0.0828	0.1392
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0502	0.0969
Onchocerca volvulus		0.087	0.1839	0.3481
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0395	0.0657	0.5
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0332	0.0502	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0056	0.0108
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0395	0.0657	0.5
Loa Loa (eye worm)	hypothetical protein	0.0179	0.012	0.0232
Schistosoma mansoni	chromobox protein	0.0954	0.2047	0.2047
Toxoplasma gondii	PLU-1 family protein	0.0213	0.0204	1
Echinococcus multilocularis	muscleblind protein 1	0.0149	0.0046	0.0077
Brugia malayi	Cation transporter family protein	0.087	0.1839	0.3552
Echinococcus multilocularis	tumor suppressor p53 binding protein 1	0.1584	0.3615	0.6074
Schistosoma mansoni	nAChR subunit	0.0153	0.0056	0.0056
Echinococcus granulosus	polycomb protein SCMH1	0.1286	0.2874	0.483
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0502	0.0969
Schistosoma mansoni	neurotransmitter gated ion channel	0.0179	0.012	0.012
Echinococcus granulosus	chromobox protein 2	0.0954	0.2047	0.3441
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0332	0.0502	0.0843
Loa Loa (eye worm)	ACC-1 protein	0.0332	0.0502	0.0969
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0332	0.0502	0.0843
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0153	0.0056	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0056	0.0108
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0332	0.0502	0.0969
Echinococcus granulosus	glycine receptor subunit beta	0.0332	0.0502	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0056	0.0108
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0332	0.0502	0.0843
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0153	0.0056	0.0094
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0153	0.0056	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0056	0.0108
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.087	0.1839	0.1839
Onchocerca volvulus		0.0332	0.0502	0.087
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0056	0.0108
Brugia malayi	hypothetical protein	0.0153	0.0056	0.0108
Brugia malayi	Cation transporter family protein	0.0332	0.0502	0.0969
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0332	0.0502	0.0502
Schistosoma mansoni	nAChR subunit	0.0332	0.0502	0.0502
Schistosoma mansoni	hypothetical protein	0.1584	0.3615	0.3615
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0056	0.0108
Schistosoma mansoni	sex comb on midleg homolog	0.1286	0.2874	0.2874
Echinococcus multilocularis	SAM and MBT domain containing protein	0.1862	0.4308	0.7239
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.2523	0.5951	1
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0502	0.0969
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0153	0.0056	0.0108
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.2212	0.5179	1
Plasmodium vivax	JmjC domain containing protein	0.0141	0.0025	0.5
Entamoeba histolytica	hypothetical protein	0.0179	0.012	0.5
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0332	0.0502	0.0969
Echinococcus granulosus	nAChR subunit	0.0179	0.012	0.0202
Loa Loa (eye worm)	ACC-1 protein	0.0332	0.0502	0.0969
Schistosoma mansoni	neurotransmitter gated ion channel	0.0153	0.0056	0.0056
Brugia malayi	jmjC domain containing protein	0.0663	0.1324	0.2556
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0332	0.0502	0.0969
Loa Loa (eye worm)	hypothetical protein	0.2212	0.5179	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.087	0.1839	0.1839
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0332	0.0502	0.0969
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0464	0.0828	0.1392
Schistosoma mansoni	jumonji/arid domain-containing protein	0.045	0.0795	0.0795
Echinococcus granulosus	lysine specific demethylase 5A	0.045	0.0795	0.1336
Brugia malayi	mbt repeat family protein	0.2212	0.5179	1
Loa Loa (eye worm)	MBCTL1	0.0464	0.0828	0.16
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0502	0.0969
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0153	0.0056	0.0108
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0332	0.0502	0.0502
Echinococcus granulosus	glycine receptor subunit beta	0.0332	0.0502	0.0843
Echinococcus multilocularis	glycine receptor subunit beta	0.0332	0.0502	0.0843
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0153	0.0056	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0149	0.0046	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0056	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0179	0.012	0.0232
Loa Loa (eye worm)	LGC-31 protein	0.0332	0.0502	0.0969
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0332	0.0502	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0179	0.012	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0056	0.0108
Echinococcus multilocularis	muscleblind protein	0.0149	0.0046	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0056	0.0108
Brugia malayi	hypothetical protein	0.0153	0.0056	0.0108
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0332	0.0502	0.0843
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0153	0.0056	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0502	0.0969
Onchocerca volvulus		0.146	0.3307	0.6347
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0502	0.0969
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0332	0.0502	0.0969
Loa Loa (eye worm)	jmjC domain-containing protein	0.0663	0.1324	0.2556
Brugia malayi	excitatory GABA receptor EXP-1A	0.0332	0.0502	0.0969
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0141	0.0025	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0332	0.0502	0.0969
Loa Loa (eye worm)	mbt repeat family protein	0.1338	0.3004	0.58
Loa Loa (eye worm)	hypothetical protein	0.087	0.1839	0.3552
Echinococcus granulosus	nAChR subunit	0.0332	0.0502	0.0843
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0332	0.0502	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0056	0.0108
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0332	0.0502	0.0843
Brugia malayi	mbt repeat family protein	0.1338	0.3004	0.58
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0056	0.0108
Schistosoma mansoni	acetylcholine receptor-related	0.0153	0.0056	0.0056
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0464	0.0828	0.16
Schistosoma mansoni	nAChR subunit	0.0332	0.0502	0.0502
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0332	0.0502	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0502	0.0969
Onchocerca volvulus		0.0179	0.012	0.0125
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0332	0.0502	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0179	0.012	0.0232
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0332	0.0502	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0464	0.0828	0.16
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0332	0.0502	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0502	0.0969
Onchocerca volvulus		0.087	0.1839	0.3481
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0153	0.0056	0.0108
Loa Loa (eye worm)	GABA receptor subunit	0.0179	0.012	0.0232
Onchocerca volvulus		0.0332	0.0502	0.087
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0332	0.0502	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0056	0.0108
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0153	0.0056	0.0108
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0332	0.0502	0.0843
Echinococcus granulosus	tumor suppressor p53 binding protein 1	0.1584	0.3615	0.6074
Schistosoma mansoni	nAChR subunit	0.0332	0.0502	0.0502
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0179	0.012	0.012
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0332	0.0502	0.0969
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0332	0.0502	0.0843
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0332	0.0502	0.0502
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0153	0.0056	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0502	0.0969
Onchocerca volvulus		0.0179	0.012	0.0125
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0332	0.0502	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0056	0.0108
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0464	0.0828	0.1392
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0179	0.012	0.0232
Echinococcus multilocularis	nAChR subunit	0.0179	0.012	0.0202
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0552	0.1049	0.1762
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0502	0.0969
Echinococcus granulosus	histone acetyltransferase myst3	0.0197	0.0165	0.0277
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0332	0.0502	0.0502
Echinococcus multilocularis	glycine receptor subunit beta	0.0332	0.0502	0.0843
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0332	0.0502	0.0969
Echinococcus multilocularis	lysine specific demethylase 5A	0.0375	0.0608	0.1022
Brugia malayi	hypothetical protein	0.0153	0.0056	0.0108
Brugia malayi	Muscleblind-like protein	0.0149	0.0046	0.0088
Schistosoma mansoni	sex comb on midleg homolog	0.1286	0.2874	0.2874
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0332	0.0502	0.0969
Echinococcus granulosus	muscleblind protein	0.0149	0.0046	0.0077
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0332	0.0502	0.0969
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.1862	0.4308	0.4308
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0332	0.0502	0.0969
Brugia malayi	hypothetical protein	0.0153	0.0056	0.0108
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0179	0.012	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0502	0.0969
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0332	0.0502	0.0969
Schistosoma mansoni	nAChR subunit	0.0332	0.0502	0.0502
Echinococcus multilocularis	polycomb protein SCMH1	0.1286	0.2874	0.483
Brugia malayi	hypothetical protein	0.0153	0.0056	0.0108
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0332	0.0502	0.0843
Onchocerca volvulus		0.087	0.1839	0.3481
Schistosoma mansoni	neurotransmitter gated ion channel	0.0153	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0149	0.0046	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0502	0.0969
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0179	0.012	0.0232
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0153	0.0056	0.0108
Echinococcus multilocularis	nAChR subunit	0.0332	0.0502	0.0843
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0332	0.0502	0.0843
Schistosoma mansoni	phd finger protein	0.0197	0.0165	0.0165
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0332	0.0502	0.0843
Onchocerca volvulus		0.0332	0.0502	0.087
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0179	0.012	0.0232
Schistosoma mansoni	nAChR subunit	0.0332	0.0502	0.0502
Loa Loa (eye worm)	acetylcholine receptor protein	0.0153	0.0056	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0332	0.0502	0.0969
Schistosoma mansoni	nAChR subunit	0.0153	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0179	0.012	0.0232
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0464	0.0828	0.0828

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 8.19	Inhibition of human soluble epoxide hydrolase in cell free system	ChEMBL.	21192659
IC50 (binding)	= 8.33	Inhibition of soluble epoxide hydrolase in human HepG2 cells after 30 mins	ChEMBL.	21192659
IC50 (binding)	= 8.52	Inhibition of rat soluble epoxide hydrolase in cell free system	ChEMBL.	21192659
IC50 (ADMET)	< 10 uM	Inhibition of CYP2C19	ChEMBL.	21192659

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1672128

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1508145