Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.3004 | 0.3004 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0182 | 0.8232 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0057 | 0.1733 | 0.9803 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0182 | 0.8232 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0058 | 0.1768 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0058 | 0.1768 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3004 | 0.3004 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.3004 | 0.3229 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0511 | 0.17 |
Schistosoma mansoni | protein kinase | 0.0058 | 0.1768 | 0.5884 |
Schistosoma mansoni | protein kinase | 0.0058 | 0.1768 | 0.5884 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0035 | 0.0546 | 0.0045 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0058 | 0.1768 | 0.1628 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.3004 | 0.3229 |
Entamoeba histolytica | protein kinase, putative | 0.0035 | 0.0546 | 0.0277 |
Entamoeba histolytica | protein kinase, putative | 0.0035 | 0.0546 | 0.0277 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0511 | 0.17 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0511 | 0.17 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0058 | 0.1768 | 0.1628 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.3004 | 0.3229 |
Trichomonas vaginalis | STE family protein kinase | 0.0058 | 0.1768 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.3004 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3004 | 0.3004 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.3004 | 0.3229 |
Schistosoma mansoni | protein kinase | 0.0034 | 0.0511 | 0.17 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.3004 | 0.3004 |
Schistosoma mansoni | wiskott-aldrich syndrome protein | 0.0034 | 0.0511 | 0.17 |
Entamoeba histolytica | protein kinase, putative | 0.0058 | 0.1768 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0058 | 0.1768 | 0.1628 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0034 | 0.0511 | 0.0511 |
Trichomonas vaginalis | STE family protein kinase | 0.0058 | 0.1768 | 1 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0058 | 0.1768 | 0.1628 |
Loa Loa (eye worm) | P21-Rho-binding domain-containing protein | 0.0034 | 0.0511 | 0.0511 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.3004 | 0.3229 |
Trichomonas vaginalis | STE family protein kinase | 0.0058 | 0.1768 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0034 | 0.0511 | 0.17 |
Giardia lamblia | Kinase, STE STE20 | 0.0058 | 0.1768 | 0.5 |
Brugia malayi | WH1 domain containing protein | 0.0034 | 0.0511 | 0.0511 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0034 | 0.0511 | 0.0511 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0034 | 0.0511 | 0.17 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0058 | 0.1768 | 0.1628 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.3004 | 0.3004 |
Schistosoma mansoni | protein kinase | 0.0035 | 0.0546 | 0.1816 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.3004 | 0.3004 |
Trichomonas vaginalis | STE family protein kinase | 0.0035 | 0.0546 | 0.3086 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1733 | 0.1733 |
Entamoeba histolytica | protein kinase, putative | 0.0035 | 0.0546 | 0.0277 |
Brugia malayi | Protein kinase domain | 0.0058 | 0.1768 | 0.1768 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.3004 | 0.3229 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0058 | 0.1768 | 0.1628 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.068 uM | Inhibition of human AChE using acetylthiocholine iodide as substrate by Ellman's assay | ChEMBL. | 21397996 |
IC50 (binding) | = 39 uM | Inhibition of human BChE using butyrylthiocholine iodide as substrate by Ellman's method | ChEMBL. | 21397996 |
Inhibition (binding) | = 30.5 % | Inhibition of human AChE-induced beta-amyloid (1-40) aggregation at 100 uM by thioflavin-T based fluorimetric assay | ChEMBL. | 21397996 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.