Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1782 | 1 |
Mycobacterium tuberculosis | Cell division protein FtsZ | 0.0342 | 0.4361 | 1 |
Mycobacterium ulcerans | cell division protein FtsZ | 0.0342 | 0.4361 | 1 |
Brugia malayi | Cell division protein ftsZ | 0.0169 | 0.2105 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0201 | 0.5 |
Schistosoma mansoni | Smad4 | 0.001 | 0.0034 | 0.1677 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.001 | 0.0034 | 0.1677 |
Brugia malayi | Smad1 | 0.001 | 0.0034 | 0.0161 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0201 | 0.1131 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1782 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0201 | 0.5 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.001 | 0.0034 | 0.1677 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0201 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.0201 | 1 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.001 | 0.0034 | 0.1677 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0201 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0034 | 0.0161 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsZ | 0.0342 | 0.4361 | 1 |
Echinococcus granulosus | smad | 0.001 | 0.0034 | 0.1677 |
Schistosoma mansoni | smad | 0.001 | 0.0034 | 0.1677 |
Treponema pallidum | cell division protein FtsZ | 0.0342 | 0.4361 | 1 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0034 | 0.0161 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0201 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.001 | 0.0034 | 0.019 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0034 | 0.1677 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0201 | 0.0957 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0201 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0201 | 0.0462 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0034 | 0.1677 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.001 | 0.0034 | 0.1677 |
Mycobacterium leprae | cell division protein FtsZ | 0.0342 | 0.4361 | 1 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0034 | 0.0161 |
Loa Loa (eye worm) | Smad1 | 0.001 | 0.0034 | 0.019 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.001 | 0.0034 | 0.1677 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0201 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0034 | 0.0161 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0201 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0201 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1782 | 0.8466 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0034 | 0.1677 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0201 | 0.0462 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0201 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0201 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.001 | 0.0034 | 0.019 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.0201 | 1 |
Brugia malayi | Cell division protein ftsZ | 0.0164 | 0.2043 | 0.9709 |
Echinococcus granulosus | Smad4 | 0.001 | 0.0034 | 0.1677 |
Echinococcus multilocularis | Smad4 | 0.001 | 0.0034 | 0.1677 |
Echinococcus multilocularis | smad | 0.001 | 0.0034 | 0.1677 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0201 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.