Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0188 | 0.1701 | 0.1701 |
Loa Loa (eye worm) | CAMK protein kinase | 0.0181 | 0.1368 | 0.2156 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.023 | 0.349 | 0.349 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.3655 | 0.576 |
Schistosoma mansoni | nephrin | 0.023 | 0.349 | 0.4122 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.1368 | 0.1616 |
Loa Loa (eye worm) | projectin | 0.0181 | 0.1368 | 0.2156 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.023 | 0.349 | 0.4264 |
Echinococcus granulosus | contactin | 0.023 | 0.349 | 0.349 |
Echinococcus multilocularis | roundabout 2 | 0.023 | 0.349 | 0.349 |
Echinococcus granulosus | nephrin | 0.0181 | 0.1368 | 0.1368 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.023 | 0.349 | 0.349 |
Schistosoma mansoni | titin | 0.0181 | 0.1368 | 0.1616 |
Echinococcus granulosus | Down syndrome cell adhesion molecule | 0.0194 | 0.1958 | 0.1958 |
Schistosoma mansoni | cell adhesion molecule | 0.0181 | 0.1368 | 0.1616 |
Echinococcus granulosus | titin | 0.0181 | 0.1368 | 0.1368 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0295 | 0.6345 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0194 | 0.1958 | 0.1185 |
Schistosoma mansoni | cell adhesion molecule | 0.0344 | 0.8467 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0181 | 0.1368 | 0.1616 |
Schistosoma mansoni | cell adhesion molecule | 0.023 | 0.349 | 0.4122 |
Schistosoma mansoni | ephrin receptor | 0.0188 | 0.1701 | 0.2009 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.023 | 0.349 | 0.5501 |
Echinococcus multilocularis | neuroglian | 0.023 | 0.349 | 0.349 |
Echinococcus multilocularis | Down syndrome cell adhesion molecule | 0.0194 | 0.1958 | 0.1958 |
Schistosoma mansoni | cell adhesion molecule | 0.0181 | 0.1368 | 0.1616 |
Onchocerca volvulus | 0.0181 | 0.1368 | 0.5 | |
Echinococcus granulosus | titin | 0.0181 | 0.1368 | 0.1368 |
Echinococcus granulosus | neuroglian | 0.0185 | 0.1533 | 0.1533 |
Echinococcus multilocularis | roundabout 2 | 0.023 | 0.349 | 0.349 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0181 | 0.1368 | 0.2156 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.023 | 0.349 | 0.349 |
Echinococcus granulosus | twitchin | 0.0185 | 0.1533 | 0.1533 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.3655 | 0.576 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0241 | 0.3988 | 0.5264 |
Schistosoma mansoni | cell adhesion molecule | 0.023 | 0.349 | 0.4122 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.023 | 0.349 | 0.5501 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0194 | 0.1958 | 0.3085 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.349 | 0.5501 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1368 | 0.2156 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.023 | 0.349 | 0.4264 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1368 | 0.2156 |
Echinococcus multilocularis | transfer RNA-Phe | 0.0181 | 0.1368 | 0.1368 |
Echinococcus multilocularis | titin | 0.0181 | 0.1368 | 0.1368 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.023 | 0.349 | 0.349 |
Brugia malayi | hypothetical protein | 0.0295 | 0.6345 | 1 |
Onchocerca volvulus | 0.0181 | 0.1368 | 0.5 | |
Echinococcus granulosus | neuroglian | 0.023 | 0.349 | 0.349 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0181 | 0.1368 | 0.2156 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0181 | 0.1368 | 0.2156 |
Echinococcus granulosus | roundabout 2 | 0.023 | 0.349 | 0.349 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0241 | 0.3988 | 0.6285 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.023 | 0.349 | 0.4122 |
Echinococcus granulosus | roundabout 2 | 0.023 | 0.349 | 0.349 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.6345 | 1 |
Schistosoma mansoni | myosin-binding protein-related | 0.0181 | 0.1368 | 0.1616 |
Onchocerca volvulus | 0.0181 | 0.1368 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.6345 | 1 |
Schistosoma mansoni | nephrin | 0.033 | 0.7878 | 0.9304 |
Schistosoma mansoni | hemicentin | 0.0181 | 0.1368 | 0.1616 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.023 | 0.349 | 0.4264 |
Schistosoma mansoni | titin | 0.0181 | 0.1368 | 0.1616 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0181 | 0.1368 | 0.2156 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0188 | 0.1701 | 0.1701 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0295 | 0.6345 | 1 |
Schistosoma mansoni | neuroglian | 0.023 | 0.349 | 0.4122 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.023 | 0.349 | 0.349 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.6345 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.2122 | 0.3345 |
Echinococcus multilocularis | neuroglian | 0.0185 | 0.1533 | 0.1533 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0181 | 0.1368 | 0.1368 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0198 | 0.2122 | 0.2122 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4.975 | Cytotoxicity against mouse L1210 cells after 65 hrs by MTS/PES microculture tetrazolium assay | ChEMBL. | 21536434 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 21536434 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.