Detailed information for compound 1512588

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 404.485 | Formula: C22H20N4O2S
  • H donors: 1 H acceptors: 4 LogP: 4.45 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1nc2c(s1)cc(cc2)c1ccnc(n1)OCCCc1ccccc1
  • InChi: 1S/C22H20N4O2S/c1-15(27)24-22-26-19-10-9-17(14-20(19)29-22)18-11-12-23-21(25-18)28-13-5-8-16-6-3-2-4-7-16/h2-4,6-7,9-12,14H,5,8,13H2,1H3,(H,24,26,27)
  • InChiKey: PYLJLCUVXBPXSK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Starlite/ChEMBL References
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127444 All targets in OG5_127444
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica phosphatidylinositol 3-kinase, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1068 aa 927 aa 29.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0115 0.4474 0.9201
Loa Loa (eye worm) hypothetical protein 0.0115 0.4474 0.4792
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0115 0.4474 0.4792
Loa Loa (eye worm) hypothetical protein 0.0054 0.1422 0.1111
Schistosoma mansoni nuclear receptor nhr-48 0.0054 0.1422 0.0624
Loa Loa (eye worm) hypothetical protein 0.0061 0.1749 0.1505
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0058 0.1587 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.1587 0.131
Schistosoma mansoni thyroid hormone receptor 0.0115 0.4474 0.396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1032 0.1562
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0115 0.4474 0.4792
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0693 0.0803
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0061 0.1749 0.1505
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0043 0.0851 0.1157
Loa Loa (eye worm) hypothetical protein 0.0054 0.1422 0.1111
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0058 0.1587 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1032 0.1562
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0058 0.1587 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.1422 0.1111
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0115 0.4474 0.4792
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0115 0.4474 0.9201
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0115 0.4474 0.9201
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0085 0.2936 0.5839
Brugia malayi hypothetical protein 0.0054 0.1422 0.145
Loa Loa (eye worm) hypothetical protein 0.0054 0.1422 0.1111
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0115 0.4474 0.396
Echinococcus multilocularis ecdysone induced protein 78C 0.0115 0.4474 0.3558
Loa Loa (eye worm) hypothetical protein 0.0115 0.4474 0.4792
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0115 0.4474 0.3558
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0122 0.4789 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.1422 0.1111
Brugia malayi nuclear hormone receptor family member nhr-6 0.0054 0.1422 0.145
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0058 0.1587 0.2533
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0061 0.1728 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0479 0.032
Loa Loa (eye worm) hypothetical protein 0.0054 0.1422 0.1111
Schistosoma mansoni nuclear receptor 0.0054 0.1422 0.0624
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0115 0.4474 0.3558
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0115 0.4474 0.3558
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0122 0.4789 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0115 0.4474 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.1749 0.1505
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0058 0.1587 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0115 0.4474 0.9201
Brugia malayi ecdysone receptor 0.0054 0.1422 0.145
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.119 0.1918
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0058 0.1587 0.2533
Loa Loa (eye worm) hypothetical protein 0.0061 0.1749 0.1505
Brugia malayi steroid hormone receptor 0.0115 0.4474 0.9201
Brugia malayi nuclear hormone receptor 0.0054 0.1422 0.145
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0115 0.4474 0.3558
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0104 0.3908 0.7764
Brugia malayi photoreceptor-specific nuclear receptor 0.0115 0.4474 0.9201
Loa Loa (eye worm) nuclear receptor NHR-67 0.0054 0.1422 0.1111
Schistosoma mansoni steroid hormone receptor ad4bp 0.0115 0.4474 0.396
Brugia malayi Steroid receptor seven-up type 2 0.0115 0.4474 0.9201
Brugia malayi nuclear receptor NHR-88 0.0054 0.1422 0.145
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0058 0.1587 0.0804
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.008 0.2704 0.1495
Schistosoma mansoni nuclear hormone receptor 0.0054 0.1422 0.0624
Schistosoma mansoni nuclear receptor 0.0054 0.1422 0.0624
Loa Loa (eye worm) hypothetical protein 0.0115 0.4474 0.4792
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0115 0.4438 0.911
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0115 0.4474 0.9201
Onchocerca volvulus Bile acid receptor homolog 0.0115 0.4474 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.4474 0.4792
Loa Loa (eye worm) hypothetical protein 0.0115 0.4474 0.4792
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1032 0.1562
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0115 0.4474 0.9201
Loa Loa (eye worm) hypothetical protein 0.008 0.2704 0.2658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.1587 0.281
Brugia malayi nuclear receptor RXR 0.0054 0.1422 0.145
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0115 0.4474 0.396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0892 0.1248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0338 0.0005
Loa Loa (eye worm) hypothetical protein 0.0054 0.1422 0.1111
Brugia malayi nuclear receptor NHR-67 0.0054 0.1422 0.145
Toxoplasma gondii target of rapamycin (TOR), putative 0.0044 0.0892 0.5
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0054 0.1422 0.0624
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0043 0.0851 0.1157
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0115 0.4474 0.396
Brugia malayi nuclear hormone receptor 0.0115 0.4474 0.9201
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0122 0.4789 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0115 0.4474 0.396
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0115 0.4474 0.4792
Loa Loa (eye worm) DR-78 0.0054 0.1422 0.1111
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0122 0.4789 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.1587 0.281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0892 0.1248
Loa Loa (eye worm) hypothetical protein 0.0054 0.1422 0.1111
Loa Loa (eye worm) nuclear hormone receptor 0.0054 0.1422 0.1111
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0122 0.4789 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0085 0.2936 0.5839
Brugia malayi nuclear receptor RXR 0.0061 0.1749 0.228
Loa Loa (eye worm) phosphatidylinositol 3 0.0202 0.8792 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0058 0.1587 0.1869
Onchocerca volvulus Protein ultraspiracle homolog 0.0115 0.4474 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0115 0.4474 0.396
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0058 0.1587 0.0192
Loa Loa (eye worm) hypothetical protein 0.0054 0.1422 0.1111
Giardia lamblia GTOR 0.0058 0.1587 0.9047
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0061 0.1749 0.0981
Brugia malayi nuclear receptor NHR-88 0.0115 0.4474 0.9201
Schistosoma mansoni nuclear hormone receptor 0.0054 0.1422 0.0624
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0115 0.4474 0.9201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0479 0.032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0115 0.4474 0.4792
Brugia malayi nuclear hormone receptor family member odr-7 0.0054 0.1422 0.145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0892 0.1248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1032 0.1562
Loa Loa (eye worm) hypothetical protein 0.0115 0.4474 0.4792
Loa Loa (eye worm) hypothetical protein 0.0061 0.1749 0.1505
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0115 0.4474 0.4792
Loa Loa (eye worm) hypothetical protein 0.0054 0.1422 0.1111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0495 0.0356
Echinococcus granulosus ecdysone induced protein 78C 0.0115 0.4474 0.3558
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0115 0.4474 0.9201
Brugia malayi Nuclear hormone receptor E75 0.0054 0.1422 0.145
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0122 0.4789 1
Schistosoma mansoni zinc finger protein 0.0054 0.1422 0.0624
Brugia malayi conserved hypotetical protein 0.0054 0.1422 0.145
Brugia malayi tailless protein 0.0054 0.1422 0.145
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0115 0.4474 0.3558
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0043 0.0851 0.0817
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0115 0.4474 0.3558
Loa Loa (eye worm) hypothetical protein 0.0054 0.1422 0.1111
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0115 0.4474 0.3558
Loa Loa (eye worm) steroid hormone receptor 0.0115 0.4474 0.4792
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0122 0.4789 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0115 0.4474 0.3558
Loa Loa (eye worm) hypothetical protein 0.0061 0.1749 0.1505
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0054 0.1422 0.0624
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0054 0.1422 0.1111
Brugia malayi ecdysteroid receptor 0.0115 0.4474 0.9201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0892 0.1248
Loa Loa (eye worm) hypothetical protein 0.0042 0.0782 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0115 0.4474 0.9201
Brugia malayi Nuclear hormone receptor-like 1 0.0061 0.1749 0.228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0495 0.0356
Brugia malayi Nuclear hormone receptor-like 1 0.0115 0.4474 0.9201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0115 0.4474 0.4792
Brugia malayi hypothetical protein 0.0061 0.1749 0.228
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0115 0.4474 0.3558
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0115 0.4474 0.9201
Brugia malayi Nuclear hormone receptor-like 1 0.0061 0.1749 0.228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0635 0.0671
Brugia malayi hypothetical protein 0.0061 0.1749 0.228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0495 0.0356
Loa Loa (eye worm) hypothetical protein 0.0115 0.4474 0.4792
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0115 0.4474 0.3558
Schistosoma mansoni RAR-like nuclear receptor 0.0115 0.4474 0.396
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0061 0.1749 0.0381
Echinococcus multilocularis FTZ F1 alpha 0.0115 0.4474 0.3558
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0058 0.1587 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0338 0.0005
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0054 0.1422 0.145
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.008 0.2704 0.1495
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0061 0.1749 0.0381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1032 0.1562
Echinococcus granulosus FTZ F1 alpha 0.0115 0.4474 0.3558
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0115 0.4474 0.9201
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0098 0.358 0.6931
Schistosoma mansoni thyroid hormone receptor 0.0115 0.4474 0.396
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.008 0.2704 0.4706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0892 0.1248
Entamoeba histolytica hypothetical protein 0.0098 0.358 0.6931
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0056 0.1496 0.1637
Onchocerca volvulus 0.0115 0.4474 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.1422 0.1111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0338 0.0005
Trypanosoma cruzi target of rapamycin kinase 3 0.0047 0.1034 0.1243
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0058 0.1587 0.1869
Brugia malayi Nuclear hormone receptor E75 0.0054 0.1422 0.145
Schistosoma mansoni coup transcription factor 0.0115 0.4474 0.396
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0043 0.0851 0.1157
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0115 0.4474 0.9201
Brugia malayi hypothetical protein 0.0054 0.1422 0.145
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0115 0.4474 0.3558
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.1587 0.281
Loa Loa (eye worm) hypothetical protein 0.0054 0.1422 0.1111
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0115 0.4474 0.396
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0115 0.4474 0.3558
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0061 0.1749 0.0981
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0043 0.0851 0.5364
Brugia malayi orphan nuclear receptor NR2E1 0.0054 0.1422 0.145
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0115 0.4474 0.3558
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0047 0.1034 0.6514
Schistosoma mansoni retinoic acid receptor RXR 0.0115 0.4474 0.396
Echinococcus multilocularis thyroid hormone receptor alpha 0.0115 0.4474 0.3558
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0029 0.0156 0.0985
Loa Loa (eye worm) hypothetical protein 0.0115 0.4474 0.4792
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.1587 0.1869
Schistosoma mansoni nuclear hormone receptor 0.0115 0.4474 0.396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0892 0.1248
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0115 0.4474 0.9201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0892 0.1248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0338 0.0005

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 6000 nM Inhibition of mTOR assessed as inhibition of 4EBP1 phosphorylation by TR-FRET assay ChEMBL. 21332118
Ki (binding) = 32 nM Inhibition of human PI3Kalpha expressed in Sf9 cells ChEMBL. 21332118

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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