Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium channel, voltage-dependent, T type, alpha 1H subunit | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | Get druggable targets OG5_129328 | All targets in OG5_129328 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | Get druggable targets OG5_129328 | All targets in OG5_129328 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129328 | All targets in OG5_129328 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Doublecortin family protein | 0.0023 | 0.0218 | 0.0313 |
Onchocerca volvulus | 0.0032 | 0.0519 | 0.4452 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0893 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0893 | 0.1282 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.0519 | 0.0738 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0893 | 0.1282 |
Schistosoma mansoni | lipoxygenase | 0.0138 | 0.4288 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0893 | 0.1658 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.0144 | 0.4489 | 0.3948 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0208 | 0.6763 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0023 | 0.0218 | 0.5 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0144 | 0.4489 | 0.3948 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | 0.0214 | 0.697 | 1 |
Onchocerca volvulus | 0.0032 | 0.0519 | 0.4452 | |
Schistosoma mansoni | intermediate filament proteins | 0.0032 | 0.0519 | 0.0738 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0893 | 0.1282 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0893 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0893 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.697 | 1 |
Echinococcus multilocularis | musashi | 0.0032 | 0.0519 | 0.0738 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0893 | 0.1658 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0498 | 0.0715 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0893 | 0.1282 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0893 | 0.5 |
Echinococcus multilocularis | lamin | 0.0032 | 0.0519 | 0.0738 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.027 | 0.8933 | 0.8828 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0218 | 0.0313 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0218 | 0.0313 |
Schistosoma mansoni | lamin | 0.0032 | 0.0519 | 0.0738 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.0519 | 0.0738 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0893 | 0.1282 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.0519 | 0.0744 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0138 | 0.4288 | 1 |
Onchocerca volvulus | 0.0042 | 0.0893 | 1 | |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0144 | 0.4489 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0042 | 0.0893 | 0.5 |
Schistosoma mansoni | lamin | 0.0032 | 0.0519 | 0.0738 |
Loa Loa (eye worm) | doublecortin family protein | 0.0023 | 0.0218 | 0.0313 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0893 | 0.1282 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0138 | 0.4288 | 1 |
Onchocerca volvulus | 0.0042 | 0.0893 | 1 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.0519 | 0.0744 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.0519 | 0.0738 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0893 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.0519 | 0.0744 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0893 | 0.1282 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0218 | 0.0313 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.0519 | 0.0744 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0893 | 0.1282 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0218 | 0.0313 |
Schistosoma mansoni | lipoxygenase | 0.0097 | 0.2818 | 0.6387 |
Leishmania major | hypothetical protein, conserved | 0.0042 | 0.0893 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0519 | 0.0744 |
Onchocerca volvulus | 0.0042 | 0.0893 | 1 | |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0893 | 0.1282 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0893 | 0.1658 |
Trypanosoma brucei | beta lactamase | 0.0144 | 0.4489 | 1 |
Echinococcus granulosus | lamin | 0.0032 | 0.0519 | 0.0738 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0893 | 0.1658 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0893 | 0.1282 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 10 uM | PUBCHEM_BIOASSAY: Inhibitors of T-Type Calcium Channels (SynthLib2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID449739, AID463087, AID489005, AID493041, AID504579, AID504584, AID504619, AID504628] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.