Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Saccharomyces cerevisiae | Rce1p | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Sus scrofa | Trypsin | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | CG31326 gene product from transcript CG31326-RA | Trypsin | 231 aa | 249 aa | 24.1 % |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | Trypsin | 231 aa | 300 aa | 22.3 % |
Drosophila melanogaster | CG9997 gene product from transcript CG9997-RB | Trypsin | 231 aa | 194 aa | 23.2 % |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | Trypsin | 231 aa | 286 aa | 25.2 % |
Loa Loa (eye worm) | hypothetical protein | Trypsin | 231 aa | 238 aa | 21.4 % |
Drosophila melanogaster | CG3916 gene product from transcript CG3916-RA | Trypsin | 231 aa | 245 aa | 31.4 % |
Schistosoma japonicum | ko:K09637 transmembrane protease, serine 6, putative | Trypsin | 231 aa | 242 aa | 28.9 % |
Drosophila melanogaster | CG34436 gene product from transcript CG34436-RA | Trypsin | 231 aa | 214 aa | 22.0 % |
Drosophila melanogaster | CG32277 gene product from transcript CG32277-RA | Trypsin | 231 aa | 221 aa | 33.5 % |
Echinococcus granulosus | transmembrane protease serine 3 | Trypsin | 231 aa | 234 aa | 33.8 % |
Drosophila melanogaster | CG17239 gene product from transcript CG17239-RB | Trypsin | 231 aa | 227 aa | 33.5 % |
Drosophila melanogaster | CG4914 gene product from transcript CG4914-RA | Trypsin | 231 aa | 245 aa | 38.8 % |
Trypanosoma cruzi | hypothetical protein, conserved | Trypsin | 231 aa | 188 aa | 23.9 % |
Drosophila melanogaster | CG10405 gene product from transcript CG10405-RB | Trypsin | 231 aa | 242 aa | 31.8 % |
Drosophila melanogaster | Jonah 65Aii | Trypsin | 231 aa | 235 aa | 35.3 % |
Drosophila melanogaster | CG30288 gene product from transcript CG30288-RC | Trypsin | 231 aa | 245 aa | 29.0 % |
Drosophila melanogaster | CG30083 gene product from transcript CG30083-RB | Trypsin | 231 aa | 209 aa | 29.7 % |
Echinococcus multilocularis | glycoprotein Antigen 5 | Trypsin | 231 aa | 301 aa | 22.3 % |
Drosophila melanogaster | Spatzle-Processing Enzyme | Trypsin | 231 aa | 271 aa | 29.1 % |
Echinococcus granulosus | enteropeptidase | Trypsin | 231 aa | 230 aa | 28.3 % |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Trypsin | 231 aa | 302 aa | 24.8 % |
Drosophila melanogaster | CG33465 gene product from transcript CG33465-RC | Trypsin | 231 aa | 225 aa | 21.8 % |
Drosophila melanogaster | CG33458 gene product from transcript CG33458-RA | Trypsin | 231 aa | 254 aa | 28.4 % |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Trypsin | 231 aa | 247 aa | 35.2 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Echinococcus multilocularis | enteropeptidase | Trypsin | 231 aa | 230 aa | 27.8 % |
Drosophila melanogaster | CG31220 gene product from transcript CG31220-RB | Trypsin | 231 aa | 263 aa | 27.8 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin | 231 aa | 201 aa | 22.9 % |
Onchocerca volvulus | Trypsin | 231 aa | 212 aa | 21.2 % | |
Drosophila melanogaster | Jonah 66Ci | Trypsin | 231 aa | 234 aa | 32.9 % |
Drosophila melanogaster | CG3505 gene product from transcript CG3505-RA | Trypsin | 231 aa | 232 aa | 30.6 % |
Schistosoma japonicum | Transmembrane protease, serine 9, putative | Trypsin | 231 aa | 246 aa | 21.1 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin | 231 aa | 235 aa | 25.5 % |
Drosophila melanogaster | Jonah 99Ci | Trypsin | 231 aa | 235 aa | 31.9 % |
Drosophila melanogaster | CG9733 gene product from transcript CG9733-RB | Trypsin | 231 aa | 262 aa | 31.3 % |
Echinococcus multilocularis | transmembrane protease serine 3 | Trypsin | 231 aa | 233 aa | 33.0 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin | 231 aa | 235 aa | 25.5 % |
Drosophila melanogaster | CG30287 gene product from transcript CG30287-RA | Trypsin | 231 aa | 249 aa | 27.7 % |
Drosophila melanogaster | CG6582 gene product from transcript CG6582-RA | Trypsin | 231 aa | 187 aa | 23.5 % |
Drosophila melanogaster | CG14990 gene product from transcript CG14990-RA | Trypsin | 231 aa | 238 aa | 29.4 % |
Echinococcus granulosus | glycoprotein Antigen 5 | Trypsin | 231 aa | 301 aa | 23.9 % |
Drosophila melanogaster | Jonah 65Aiii | Trypsin | 231 aa | 241 aa | 34.0 % |
Echinococcus multilocularis | Mastin | Trypsin | 231 aa | 306 aa | 24.2 % |
Drosophila melanogaster | CG30323 gene product from transcript CG30323-RB | Trypsin | 231 aa | 210 aa | 23.3 % |
Echinococcus granulosus | Mastin | Trypsin | 231 aa | 306 aa | 23.9 % |
Schistosoma japonicum | Enteropeptidase, putative | Trypsin | 231 aa | 262 aa | 25.6 % |
Drosophila melanogaster | CG5909 gene product from transcript CG5909-RA | Trypsin | 231 aa | 256 aa | 28.9 % |
Drosophila melanogaster | CG18420 gene product from transcript CG18420-RA | Trypsin | 231 aa | 239 aa | 28.4 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin | 231 aa | 237 aa | 24.1 % |
Neospora caninum | ELMO/CED-12 family domain-containing protein, putative | Trypsin | 231 aa | 193 aa | 22.8 % |
Schistosoma japonicum | Cercarial protease precursor (EC 3.4.21.-) (Cercarial elastase), putative | Trypsin | 231 aa | 204 aa | 25.0 % |
Drosophila melanogaster | CG11313 gene product from transcript CG11313-RC | Trypsin | 231 aa | 255 aa | 31.8 % |
Drosophila melanogaster | CG4815 gene product from transcript CG4815-RA | Trypsin | 231 aa | 212 aa | 27.4 % |
Schistosoma japonicum | IPR001254,Peptidase S1 and S6, chymotrypsin/Hap;IPR009003,Peptidase, trypsin-like serine and cysteine,domain-containing | Trypsin | 231 aa | 225 aa | 23.1 % |
Schistosoma japonicum | ko:K01346 pancreatic elastase II [EC3.4.21.71], putative | Trypsin | 231 aa | 303 aa | 24.1 % |
Drosophila melanogaster | CG31267 gene product from transcript CG31267-RA | Trypsin | 231 aa | 233 aa | 32.2 % |
Drosophila melanogaster | CG13744 gene product from transcript CG13744-RA | Trypsin | 231 aa | 249 aa | 31.3 % |
Drosophila melanogaster | CG9673 gene product from transcript CG9673-RB | Trypsin | 231 aa | 239 aa | 27.6 % |
Onchocerca volvulus | Trypsin | 231 aa | 251 aa | 22.7 % | |
Drosophila melanogaster | CG18180 gene product from transcript CG18180-RA | Trypsin | 231 aa | 233 aa | 27.9 % |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | Trypsin | 231 aa | 286 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0111 | 0.5756 | 0.5 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0111 | 0.5756 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0111 | 0.5756 | 0.5 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0111 | 0.5756 | 0.5 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0111 | 0.5756 | 0.5 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0111 | 0.5756 | 0.5 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0111 | 0.5756 | 0.5 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0111 | 0.5756 | 0.5 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0111 | 0.5756 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | = 6.65 uM | PUBCHEM_BIOASSAY: Trypsin Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] | ChEMBL. | No reference |
AC50 (binding) | = 13.47 uM | PUBCHEM_BIOASSAY: Ras-converting Enzyme/Cell Proliferation Pathway Measured in Biochemical System Using Plate Reader - 2034-01_Inhibitor_Dose_CherryPick. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] | ChEMBL. | No reference |
IC50 (functional) | 100 uM | PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.5012 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.