Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | carnitine palmitoyltransferase-like protein | 0.1556 | 0.2199 | 0.2124 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0109 | 0.0125 | 0.0993 |
Onchocerca volvulus | 0.0109 | 0.0125 | 0.0993 | |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.1556 | 0.2199 | 0.3859 |
Schistosoma mansoni | choline o-acyltransferase | 0.0898 | 0.1256 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0109 | 0.0125 | 0.0993 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0898 | 0.1256 | 0.2203 |
Schistosoma mansoni | choline o-acyltransferase | 0.0898 | 0.1256 | 1 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0898 | 0.1256 | 0.1256 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0109 | 0.0125 | 0.0125 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0287 | 0.038 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.1556 | 0.2199 | 0.2199 |
Echinococcus granulosus | choline O acetyltransferase | 0.0898 | 0.1256 | 0.2203 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0125 | 0.0125 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0898 | 0.1256 | 0.1256 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0267 | 0.0351 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.6994 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0109 | 0.0125 | 0.0219 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0109 | 0.0125 | 0.0125 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0898 | 0.1256 | 0.1256 |
Brugia malayi | Choline O-acetyltransferase | 0.0898 | 0.1256 | 0.1256 |
Brugia malayi | Choline O-acetyltransferase | 0.0898 | 0.1256 | 0.1256 |
Loa Loa (eye worm) | serotonin transporter b | 0.0109 | 0.0125 | 0.0125 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0109 | 0.0125 | 0.0125 |
Onchocerca volvulus | 0.0898 | 0.1256 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0125 | 0.0125 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.3996 | 0.5699 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0109 | 0.0125 | 0.0219 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3996 | 0.5699 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0109 | 0.0125 | 0.5 |
Onchocerca volvulus | 0.0898 | 0.1256 | 1 | |
Onchocerca volvulus | 0.0898 | 0.1256 | 1 | |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.1556 | 0.2199 | 0.2124 |
Onchocerca volvulus | 0.0898 | 0.1256 | 1 | |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.1556 | 0.2199 | 0.2199 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.1556 | 0.2199 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0125 | 0.0125 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0287 | 0.038 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0898 | 0.1256 | 0.1256 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.3996 | 0.5699 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.3996 | 0.5699 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.3996 | 0.5699 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.1556 | 0.2199 | 0.3859 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.12 nM | Affinity against cocaine binding site of dopamine transporter in rat striatum using [3H]-2b as radioligand. | ChEMBL. | 1895292 |
IC50 (binding) | = 0.002 uM | Inhibition of [3H]-WIN-35,428 binding to the dopamine transporter | ChEMBL. | 1552510 |
IC50 (binding) | = 0.2 uM | Inhibition of dopamine uptake at dopamine transporter. | ChEMBL. | 1552510 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.