TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 309.405 | Formula: C19H23N3O
H donors: 0 H acceptors: 3 LogP: 3.72 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cnc2c(n1)cccc2)N1CCCC2(C1)CCCCC2
InChi: 1S/C19H23N3O/c23-18(17-13-20-15-7-2-3-8-16(15)21-17)22-12-6-11-19(14-22)9-4-1-5-10-19/h2-3,7-8,13H,1,4-6,9-12,14H2
InChiKey: ZJDYQLOLXCNEQG-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutamate receptor, metabotropic 5	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	Metabotropic glutamate receptor precursor, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	Get druggable targets OG5_127095	All targets in OG5_127095
Brugia malayi	Metabotropic glutamate receptor precursor.	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus multilocularis	metabotropic glutamate receptor 5	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Loa Loa (eye worm)	glutamate receptor	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	ko:K04606 glutamate receptor, metabotropic 3, putative	Get druggable targets OG5_127095	All targets in OG5_127095
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127095	All targets in OG5_127095
Echinococcus granulosus	metabotropic glutamate receptor 2	Get druggable targets OG5_127095	All targets in OG5_127095

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0029	0.0151	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0151	0.0151
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0041	0.0351	0.1144
Schistosoma mansoni	coup transcription factor	0.0054	0.0564	0.191
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0054	0.0564	0.0532
Echinococcus multilocularis	ecdysone induced protein 78C	0.0054	0.0564	0.191
Echinococcus granulosus	jun protein	0.0093	0.1188	0.5041
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0054	0.0564	0.2316
Brugia malayi	hypothetical protein	0.0029	0.0151	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0564	0.0564
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0026	0.0102	0.0246
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0054	0.0564	0.191
Brugia malayi	Nuclear hormone receptor-like 1	0.0029	0.0151	0.0118
Brugia malayi	MH2 domain containing protein	0.0132	0.182	0.1793
Loa Loa (eye worm)	hypothetical protein	0.009	0.1147	0.1147
Schistosoma mansoni	nuclear receptor	0.0026	0.0102	0.0246
Onchocerca volvulus		0.0073	0.0866	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0033	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0193	0.2811	1
Schistosoma mansoni	hypothetical protein	0.0075	0.0907	0.3145
Schistosoma mansoni	nuclear receptor	0.0026	0.0102	0.0246
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0093	0.1188	0.4156
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0033	0.5
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0026	0.0102	0.0246
Leishmania major	DNA polymerase eta, putative	0.0021	0.0033	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.0054	0.0564	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0564	0.0564
Brugia malayi	orphan nuclear receptor NR2E1	0.0026	0.0102	0.0068
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0139	0.1936	0.685
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0054	0.0564	0.0532
Entamoeba histolytica	hypothetical protein	0.004	0.0331	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0054	0.0564	0.0532
Trypanosoma brucei	unspecified product	0.0021	0.0033	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0054	0.0564	0.0532
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0081	0.1004	0.3492
Brugia malayi	nuclear hormone receptor family member odr-7	0.0026	0.0102	0.0068
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0054	0.0564	0.0532
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0026	0.0102	0.0102
Brugia malayi	hypothetical protein	0.0073	0.0866	0.0835
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0026	0.0102	0.0298
Brugia malayi	ecdysteroid receptor	0.0054	0.0564	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0564	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0102	0.0102
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0033	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0026	0.0102	0.0246
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0054	0.0564	0.191
Schistosoma mansoni	jun-related protein	0.0075	0.0907	0.3145
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0102	0.0102
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0054	0.0564	0.191
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0026	0.0102	0.0246
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0041	0.0351	0.1387
Onchocerca volvulus	Protein ultraspiracle homolog	0.0054	0.0564	0.6047
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0163	0.2324	1
Loa Loa (eye worm)	hypothetical protein	0.0638	1	1
Schistosoma mansoni	metabotropic glutamate receptor	0.0024	0.0074	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0102	0.0102
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0029	0.0151	0.0424
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0033	0.5
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0054	0.0564	0.191
Brugia malayi	nuclear receptor NHR-67	0.0026	0.0102	0.0068
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0054	0.0564	0.191
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0044	0.0405	0.0373
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0054	0.0564	0.0564
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0026	0.0102	0.0246
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0033	0.5
Brugia malayi	hypothetical protein	0.0029	0.0151	0.0118
Loa Loa (eye worm)	transcription factor SMAD2	0.0132	0.182	0.182
Brugia malayi	metabotropic glutamate receptor type 2	0.0024	0.0074	0.0041
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0033	0.5
Brugia malayi	nuclear receptor NHR-88	0.0026	0.0102	0.0068
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0054	0.0564	0.0564
Trichomonas vaginalis	DNA polymerase eta, putative	0.0021	0.0033	0.5
Brugia malayi	hypothetical protein	0.0026	0.0102	0.0068
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0029	0.0151	0.0151
Brugia malayi	Steroid receptor seven-up type 2	0.0054	0.0564	0.0532
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0033	0.5
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0054	0.0564	0.2316
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0054	0.0564	0.0564
Schistosoma mansoni	retinoic acid receptor RXR	0.0163	0.2324	0.8245
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0033	0.5
Brugia malayi	nuclear receptor RXR	0.0026	0.0102	0.0068
Brugia malayi	conserved hypotetical protein	0.0026	0.0102	0.0068
Schistosoma mansoni	thyroid hormone receptor	0.0193	0.2811	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0054	0.0564	0.191
Echinococcus granulosus	thyroid hormone receptor alpha	0.0026	0.0102	0.0298
Echinococcus granulosus	metabotropic glutamate receptor 5	0.006	0.0662	0.2745
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0054	0.0564	0.0564
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0026	0.0102	0.0102
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0033	0.5
Schistosoma mansoni	metabotropic glutamate receptor	0.0041	0.0351	0.1144
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0054	0.0564	0.191
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0054	0.0564	0.2316
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0093	0.1188	0.5041
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0134	0.1862	0.6581
Echinococcus granulosus	nuclear receptor nhr 48	0.0026	0.0102	0.0298
Entamoeba histolytica	hypothetical protein	0.004	0.0331	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0054	0.0564	0.191
Echinococcus multilocularis	jun protein	0.0093	0.1188	0.4156
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0033	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0033	0.5
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0026	0.0102	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0102	0.0102
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0029	0.0151	0.0424
Schistosoma mansoni	zinc finger protein	0.0026	0.0102	0.0246
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0054	0.0564	0.2316
Entamoeba histolytica	hypothetical protein	0.004	0.0331	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0054	0.0564	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0564	0.0564
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0033	0.5
Giardia lamblia	DINP protein human, muc B family	0.0021	0.0033	0.5
Loa Loa (eye worm)	glutamate receptor	0.0049	0.048	0.048
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0564	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0033	0.0033
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0033	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0026	0.0102	0.0246
Brugia malayi	Nuclear hormone receptor E75	0.0026	0.0102	0.0068
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0033	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0564	0.0564
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0054	0.0564	0.2316
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0033	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0102	0.0102
Schistosoma mansoni	nuclear receptor nhr-48	0.0026	0.0102	0.0246
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.0033	0.0033
Echinococcus granulosus	FTZ F1 alpha	0.0054	0.0564	0.2316
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0026	0.0102	0.0298
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0054	0.0564	0.6047
Schistosoma mansoni	hypothetical protein	0.0139	0.1936	0.685
Brugia malayi	hypothetical protein	0.0026	0.0102	0.0068
Onchocerca volvulus		0.0054	0.0564	0.6047
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0151	0.0151
Brugia malayi	nuclear receptor NHR-88	0.0054	0.0564	0.0532
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0054	0.0564	0.0532
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0054	0.0564	0.191
Loa Loa (eye worm)	nuclear hormone receptor	0.0026	0.0102	0.0102
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0331	0.1072
Echinococcus granulosus	ecdysone induced protein 78C	0.0054	0.0564	0.2316
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0081	0.1004	0.4236
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0102	0.0102
Brugia malayi	hypothetical protein	0.004	0.0331	0.0299
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0033	0.5
Brugia malayi	ecdysone receptor	0.0026	0.0102	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0564	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0102	0.0102
Echinococcus multilocularis	FTZ F1 alpha	0.0054	0.0564	0.191
Brugia malayi	Nuclear hormone receptor-like 1	0.0029	0.0151	0.0118
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0331	0.13
Onchocerca volvulus	Bile acid receptor homolog	0.0054	0.0564	0.6047
Brugia malayi	bZIP transcription factor family protein	0.0093	0.1188	0.1158
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0054	0.0564	0.0564
Trypanosoma cruzi	DNA polymerase eta, putative	0.0021	0.0033	0.5
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0033	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0054	0.0564	0.0532
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0054	0.0564	0.0532
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0054	0.0564	0.0532
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0049	0.048	0.0448
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0054	0.0564	0.191
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0026	0.0102	0.0246
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0054	0.0564	0.0564
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0029	0.0151	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0151	0.0151
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0054	0.0564	0.191
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0021	0.0033	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0102	0.0102
Brugia malayi	nuclear hormone receptor	0.0026	0.0102	0.0068
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0054	0.0564	0.191
Brugia malayi	Nuclear hormone receptor E75	0.0026	0.0102	0.0068
Schistosoma mansoni	nuclear hormone receptor	0.0026	0.0102	0.0246
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0054	0.0564	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0102	0.0102
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0056	0.0588	0.1996
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0054	0.0564	0.2316
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0102	0.0102
Entamoeba histolytica	hypothetical protein	0.004	0.0331	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0054	0.0564	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0151	0.0151
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0026	0.0102	0.0068
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0331	0.1072
Brugia malayi	nuclear hormone receptor	0.0054	0.0564	0.0532
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0054	0.0564	0.0532
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0054	0.0564	0.191
Loa Loa (eye worm)	MH2 domain-containing protein	0.0132	0.182	0.182
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0193	0.2811	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0662	0.0662
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0054	0.0564	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0151	0.0151
Schistosoma mansoni	hypothetical protein	0.004	0.0331	0.1072
Brugia malayi	tailless protein	0.0026	0.0102	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0102	0.0102
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0033	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0564	0.0564
Echinococcus multilocularis	nuclear receptor nhr 48	0.0026	0.0102	0.0246
Brugia malayi	nuclear receptor RXR	0.0029	0.0151	0.0118
Loa Loa (eye worm)	DR-78	0.0026	0.0102	0.0102
Schistosoma mansoni	RAR-like nuclear receptor	0.0054	0.0564	0.191
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0054	0.0564	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0102	0.0102
Brugia malayi	steroid hormone receptor	0.0054	0.0564	0.0532
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0026	0.0102	0.0068
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0033	0.5
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0026	0.0102	0.0298
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0033	0.5
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0033	0.5
Trypanosoma brucei	DNA polymerase eta, putative	0.0021	0.0033	0.5
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0033	0.5
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.006	0.0662	0.2264
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0139	0.1936	0.8308
Schistosoma mansoni	nuclear hormone receptor	0.0054	0.0564	0.191
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0033	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0054	0.0564	0.0532

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 2.39 %	Non-competitive antagonist activity at mGluR5 at 30 uM relative to glutamate	ChEMBL.	19443219
IC50 (functional)	= 5.02 uM	Non-competitive antagonist activity at mGluR5	ChEMBL.	19443219

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1783979

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1519322