Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1788 | 1 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0242 | 0.119 | 0.121 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative | 0.0242 | 0.119 | 0.121 |
Schistosoma mansoni | immunophilin | 0.1546 | 0.862 | 0.862 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1759 | 0.9835 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.1788 | 1 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1759 | 0.9835 | 1 |
Trypanosoma brucei | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0242 | 0.119 | 0.121 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0271 | 0.1355 | 0.1355 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0242 | 0.119 | 0.5 |
Echinococcus multilocularis | 0.0242 | 0.119 | 0.119 | |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0242 | 0.119 | 0.121 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.1759 | 0.9835 | 1 |
Schistosoma mansoni | immunophilin | 0.1788 | 1 | 1 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0242 | 0.119 | 0.119 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1759 | 0.9835 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1759 | 0.9835 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0242 | 0.119 | 0.119 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.1546 | 0.862 | 0.862 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1759 | 0.9835 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.1759 | 0.9835 | 0.9972 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.1759 | 0.9835 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1759 | 0.9835 | 1 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.0242 | 0.119 | 0.121 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0242 | 0.119 | 0.5 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0242 | 0.119 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0242 | 0.119 | 0.121 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0242 | 0.119 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0242 | 0.119 | 0.121 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.1759 | 0.9835 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.1788 | 1 | 1 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.1759 | 0.9835 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.1759 | 0.9835 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.1759 | 0.9835 | 1 |
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | 0.0242 | 0.119 | 0.121 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0242 | 0.119 | 0.121 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.1759 | 0.9835 | 0.9835 |
Onchocerca volvulus | 0.0242 | 0.119 | 0.98 | |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.119 | 0.121 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.1759 | 0.9835 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1759 | 0.9835 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1546 | 0.862 | 0.862 |
Leishmania major | fk506-binding protein 1-like protein | 0.1759 | 0.9835 | 1 |
Trichomonas vaginalis | fk506 binding protein, putative | 0.0242 | 0.119 | 0.121 |
Echinococcus multilocularis | fk506 binding protein | 0.1759 | 0.9835 | 0.9835 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0242 | 0.119 | 0.119 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.1759 | 0.9835 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.1759 | 0.9835 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0242 | 0.119 | 0.121 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0242 | 0.119 | 0.5 |
Leishmania major | FKBP-type peptidyl-prolyl cis-trans isomerase, putative | 0.0242 | 0.119 | 0.121 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.1759 | 0.9835 | 1 |
Schistosoma mansoni | immunophilin | 0.1788 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0242 | 0.119 | 0.121 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.1763 | 0.9859 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0242 | 0.119 | 0.5 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0242 | 0.119 | 0.5 |
Schistosoma mansoni | fk506 binding protein | 0.0242 | 0.119 | 0.119 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0242 | 0.119 | 0.121 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.1759 | 0.9835 | 0.9835 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0242 | 0.119 | 0.121 |
Loa Loa (eye worm) | FKBP5 protein | 0.1759 | 0.9835 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.1759 | 0.9835 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1521 | 0.848 | 0.8622 |
Onchocerca volvulus | 0.0246 | 0.1214 | 1 | |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0242 | 0.119 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0242 | 0.119 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 47 % | Irreversible inhibition of [135I]-AB-MECA binding to human adenosine A3 receptor at 1 nM | ChEMBL. | 11495585 |
Inhibition (binding) | = 47 % | Irreversible inhibition of [135I]-AB-MECA binding to human adenosine A3 receptor at 1 nM | ChEMBL. | 11495585 |
Inhibition (binding) | = 70 % | Irreversible inhibition of [135I]-AB-MECA binding to human adenosine A3 receptor at 10 nM | ChEMBL. | 11495585 |
Inhibition (binding) | = 70 % | Irreversible inhibition of [135I]-AB-MECA binding to human adenosine A3 receptor at 10 nM | ChEMBL. | 11495585 |
Inhibition (binding) | = 79 % | Irreversible inhibition of [135I]-AB-MECA binding to human adenosine A3 receptor at 100 nM | ChEMBL. | 11495585 |
Inhibition (binding) | = 79 % | Irreversible inhibition of [135I]-AB-MECA binding to human adenosine A3 receptor at 100 nM | ChEMBL. | 11495585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.