Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0011 | 0 | 0.5 |
Leishmania major | oxidoreductase, putative | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0526 | 0.2071 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0011 | 0 | 0.5 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0011 | 0 | 0.5 |
Brugia malayi | Alcohol dehydrogenase class III | 0.0088 | 0.0311 | 0.1503 |
Onchocerca volvulus | 0.0526 | 0.2071 | 1 | |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0526 | 0.2071 | 1 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0088 | 0.0311 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0011 | 0 | 0.5 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.0088 | 0.0311 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0088 | 0.0311 | 0.1503 |
Leishmania major | d-xylulose reductase, putative | 0.0011 | 0 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0526 | 0.2071 | 1 |
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.0088 | 0.0311 | 1 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0078 | 0.0268 | 0.8612 |
Trypanosoma brucei | oxidoreductase, putative | 0.0011 | 0 | 0.5 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.0088 | 0.0311 | 1 |
Leishmania major | zinc binding dehydrogenase-like protein | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0088 | 0.0311 | 1 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.0088 | 0.0311 | 1 |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.0088 | 0.0311 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0088 | 0.0311 | 0.0311 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0011 | 0 | 0.5 |
Echinococcus multilocularis | mitochondrial trans 2 enoyl coenzyme A reductase | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0526 | 0.2071 | 1 |
Trypanosoma brucei | oxidoreductase, putative | 0.0011 | 0 | 0.5 |
Leishmania major | quinone oxidoreductase, putative | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | tyrosinase precursor | 0.2501 | 1 | 1 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.0088 | 0.0311 | 0.1503 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0011 | 0 | 0.5 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0011 | 0 | 0.5 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0011 | 0 | 0.5 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0088 | 0.0311 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0526 | 0.2071 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0526 | 0.2071 | 1 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase | 0.0011 | 0 | 0.5 |
Leishmania major | NADP-dependent alcohol dehydrogenase, putative | 0.0011 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | NADPH:quinone reductase | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 | 0.0078 | 0.0268 | 0.8612 |
Onchocerca volvulus | 0.0526 | 0.2071 | 1 | |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0526 | 0.2071 | 1 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0526 | 0.2071 | 1 |
Onchocerca volvulus | 0.0526 | 0.2071 | 1 | |
Trypanosoma cruzi | oxidoreductase, putative | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0526 | 0.2071 | 1 |
Brugia malayi | ShTK domain containing protein | 0.0526 | 0.2071 | 1 |
Onchocerca volvulus | 0.0526 | 0.2071 | 1 | |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0526 | 0.2071 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0011 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.