Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0081 | 0.0081 |
Brugia malayi | Trehalase family protein | 0.0085 | 0.0081 | 0.0081 |
Schistosoma mansoni | alpha-glucosidase | 0.0191 | 0.1304 | 0.2811 |
Brugia malayi | hypothetical protein | 0.0085 | 0.0081 | 0.0081 |
Plasmodium vivax | hypothetical protein, conserved | 0.0147 | 0.0792 | 0.5 |
Onchocerca volvulus | 0.0246 | 0.1934 | 0.2386 | |
Treponema pallidum | hypothetical protein | 0.0085 | 0.0081 | 0.5 |
Mycobacterium leprae | Possible hydrolase | 0.0119 | 0.0473 | 0.5 |
Loa Loa (eye worm) | trehalase | 0.0085 | 0.0081 | 0.0081 |
Onchocerca volvulus | 0.0246 | 0.1934 | 0.2386 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0653 | 0.6637 | 0.6637 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0246 | 0.1934 | 0.1934 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0945 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 0.4637 | 0.4637 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0147 | 0.0792 | 0.5 |
Echinococcus granulosus | beta galactosidase | 0.048 | 0.4637 | 1 |
Loa Loa (eye worm) | trehalase | 0.0085 | 0.0081 | 0.0081 |
Brugia malayi | hypothetical protein | 0.0246 | 0.1934 | 0.1934 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.1934 | 0.1934 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.0952 | 0.0952 |
Trichomonas vaginalis | trehalase, putative | 0.0246 | 0.1934 | 0.1934 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.062 | 0.6252 | 0.6252 |
Mycobacterium tuberculosis | Conserved protein | 0.0119 | 0.0473 | 0.5 |
Brugia malayi | hypothetical protein | 0.0085 | 0.0081 | 0.0081 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0191 | 0.1304 | 0.2811 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.062 | 0.6252 | 0.6252 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0081 | 0.0081 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0191 | 0.1304 | 0.2811 |
Loa Loa (eye worm) | TRE-2 protein | 0.0246 | 0.1934 | 0.1934 |
Onchocerca volvulus | Trehalase homolog | 0.0246 | 0.1934 | 0.2386 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0945 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.062 | 0.6252 | 0.6252 |
Brugia malayi | trehalase I | 0.0085 | 0.0081 | 0.0081 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.062 | 0.6252 | 0.6252 |
Brugia malayi | Trehalase family protein | 0.0246 | 0.1934 | 0.1934 |
Loa Loa (eye worm) | TRE-1 protein | 0.0246 | 0.1934 | 0.1934 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0945 | 1 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.062 | 0.6252 | 1 |
Echinococcus multilocularis | beta galactosidase | 0.048 | 0.4637 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.1934 | 0.1934 |
Onchocerca volvulus | 0.0246 | 0.1934 | 0.2386 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.062 | 0.6252 | 0.6252 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0191 | 0.1304 | 0.1304 |
Leishmania major | glycosyl hydrolase, putative | 0.0119 | 0.0473 | 0.5 |
Brugia malayi | hypothetical protein | 0.0085 | 0.0081 | 0.0081 |
Brugia malayi | Trehalase family protein | 0.0246 | 0.1934 | 0.1934 |
Brugia malayi | trehalase | 0.0085 | 0.0081 | 0.0081 |
Schistosoma mansoni | alpha-glucosidase | 0.0191 | 0.1304 | 0.2811 |
Onchocerca volvulus | 0.0246 | 0.1934 | 0.2386 | |
Mycobacterium ulcerans | glycosyl hydrolase | 0.0119 | 0.0473 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.062 | 0.6252 | 0.6252 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0945 | 1 | 1 |
Loa Loa (eye worm) | trehalase | 0.0246 | 0.1934 | 0.1934 |
Brugia malayi | Trehalase protein 5 | 0.0085 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.1934 | 0.1934 |
Loa Loa (eye worm) | hypothetical protein | 0.0867 | 0.9107 | 0.9107 |
Onchocerca volvulus | 0.0246 | 0.1934 | 0.2386 | |
Loa Loa (eye worm) | trehalase | 0.0246 | 0.1934 | 0.1934 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0653 | 0.6637 | 0.6637 |
Brugia malayi | Trehalase family protein | 0.0085 | 0.0081 | 0.0081 |
Toxoplasma gondii | melibiase subfamily protein | 0.0078 | 0 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0191 | 0.1304 | 0.1304 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0191 | 0.1304 | 0.2811 |
Loa Loa (eye worm) | trehalase | 0.0246 | 0.1934 | 0.1934 |
Trypanosoma brucei | glycosyl hydrolase, putative | 0.0119 | 0.0473 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0081 | 0.0081 |
Trypanosoma cruzi | glycosyl hydrolase, putative | 0.0119 | 0.0473 | 0.5 |
Schistosoma mansoni | beta-galactosidase | 0.048 | 0.4637 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.062 | 0.6252 | 0.6252 |
Brugia malayi | Trehalase family protein | 0.0246 | 0.1934 | 0.1934 |
Brugia malayi | Trehalase family protein | 0.0246 | 0.1934 | 0.1934 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0945 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.1934 | 0.1934 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0945 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0945 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.1934 | 0.1934 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ISA (functional) | = 0.86 | Intrinsic Sympathomimetic Activity (ISA) determined from the ratio of the maximal compound and isoprenaline induced tachycardia in anesthetized ganglion blocked cats following intravenous administration | ChEMBL. | 2892934 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.