Detailed information for compound 1528736

Basic information

Technical information
  • TDR Targets ID: 1528736
  • Name: 2-[[5,6-di(phenyl)-1,2,4-triazin-3-yl]sulfany l]-N-(oxolan-2-ylmethyl)propanamide
  • MW: 420.527 | Formula: C23H24N4O2S
  • H donors: 1 H acceptors: 4 LogP: 3.52 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(Sc1nnc(c(n1)c1ccccc1)c1ccccc1)C)NCC1CCCO1
  • InChi: 1S/C23H24N4O2S/c1-16(22(28)24-15-19-13-8-14-29-19)30-23-25-20(17-9-4-2-5-10-17)21(26-27-23)18-11-6-3-7-12-18/h2-7,9-12,16,19H,8,13-15H2,1H3,(H,24,28)
  • InChiKey: KEISLDNNCBCKDT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[5,6-di(phenyl)-1,2,4-triazin-3-yl]sulfanyl]-N-(tetrahydrofuran-2-ylmethyl)propanamide
  • 2-[[5,6-di(phenyl)-1,2,4-triazin-3-yl]thio]-N-(2-tetrahydrofuranylmethyl)propanamide
  • 2-[[5,6-di(phenyl)-1,2,4-triazin-3-yl]thio]-N-(tetrahydrofurfuryl)propionamide
  • T5319350

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0113
Trypanosoma cruzi extracellular receptor, putative 0.0025 0.0077 0.2673
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0285 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0285 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0002 0.0004
Schistosoma mansoni metabotropic glutamate receptor 0.0025 0.0077 0.009
Brugia malayi hypothetical protein 0.0025 0.0077 0.0143
Loa Loa (eye worm) MBCTL1 0.0055 0.0453 0.0839
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0295 0.0345
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0074 0.0692 0.081
Loa Loa (eye worm) glutamate receptor 1 0.0049 0.0377 0.0698
Loa Loa (eye worm) hypothetical protein 0.0099 0.1005 0.186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0344 0.0403
Schistosoma mansoni glutamate receptor AMPA 0.0049 0.0377 0.0441
Loa Loa (eye worm) runx1 0.0056 0.0469 0.0869
Echinococcus multilocularis expressed conserved protein 0.0093 0.093 0.093
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0369 0.0432
Onchocerca volvulus 0.0447 0.5401 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0143
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0025 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0143
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0025 0.0077 0.0143
Schistosoma mansoni hypothetical protein 0.0019 0.0002 0.0002
Echinococcus multilocularis tyrosine kinase 0.0025 0.0077 0.0077
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0061 0.0448
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0295 0.0345
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0521 0.0965
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0174 0.1953 0.1953
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0077 0.0143
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0061 0.0448
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0061 0.0448
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0369 0.0684
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0061 0.5
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0074 0.0692 0.0692
Schistosoma mansoni lozenge 0.0056 0.0469 0.0549
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0074 0.0692 0.0692
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0143
Echinococcus multilocularis glutamate receptor 2 0.0025 0.0077 0.0077
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0369 0.0432
Schistosoma mansoni glutamate receptor AMPA 0.0049 0.0377 0.0441
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0074 0.0692 0.0692
Brugia malayi mbt repeat family protein 0.0048 0.0369 0.0684
Loa Loa (eye worm) hypothetical protein 0.0052 0.0415 0.0769
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0061 0.0113
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0285 1
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0049 0.0377 0.0377
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0344 0.0344
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0285 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0285 0.964
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0061 0.7904
Echinococcus granulosus GPCR family 2 0.0019 0.0002 0.0002
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.1005 0.1176
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0001 0.0003
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0369 0.0432
Toxoplasma gondii exonuclease III APE 0.0019 0.0001 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0002 0.0002
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0049 0.0377 0.0441
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0285 1
Schistosoma mansoni glutamate receptor kainate 0.0049 0.0377 0.0441
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0002 0.0004
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.1024 0.1198
Onchocerca volvulus 0.0024 0.0061 0.0113
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0061 0.7904
Schistosoma mansoni protein kinase 0.0025 0.0077 0.009
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.1005 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0874 0.1619
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0061 0.5
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0025 0.0077 0.0143
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0025 0.0077 0.0143
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.1005 0.186
Onchocerca volvulus 0.0025 0.0077 0.0143
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0061 0.0448
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0001 0.0001
Schistosoma mansoni glutamate receptor kainate 0.0049 0.0377 0.0441
Brugia malayi Glutamate receptor 2 precursor 0.0049 0.0377 0.0698
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0344 0.0403
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0453 0.053
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.1538 0.18
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0285 1
Schistosoma mansoni hypothetical protein 0.0041 0.0276 0.0323
Schistosoma mansoni glutamate receptor NMDA 0.0049 0.0377 0.0441
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0285 1
Schistosoma mansoni tyrosine kinase 0.0025 0.0077 0.009
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0143
Echinococcus granulosus atrial natriuretic peptide receptor 0.0025 0.0077 0.009
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0453 0.0453
Echinococcus granulosus receptor type guanylyl cyclase 0.0025 0.0077 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0285 1
Brugia malayi mbt repeat family protein 0.0048 0.0369 0.0684
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0074 0.0692 0.081
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.1538 0.1538
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0344 0.0344
Schistosoma mansoni ap endonuclease 0.0019 0.0001 0.0002
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0025 0.0077 0.0077
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0281 0.052
Echinococcus multilocularis protein dispatched 1 0.0048 0.0371 0.0371
Schistosoma mansoni hypothetical protein 0.0041 0.0276 0.0323
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0125 0.1338 0.5
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0074 0.0692 0.081
Schistosoma mansoni eyes absent homolog 0.0088 0.0874 0.1023
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0285 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0295 1
Leishmania major extracellular receptor, putative 0.0025 0.0077 1
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0285 0.212
Echinococcus multilocularis nmda type glutamate receptor 0.0691 0.8482 0.8482
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0285 1
Schistosoma mansoni microtubule-associated protein tau 0.0697 0.8548 1
Chlamydia trachomatis glutamine binding protein 0.0125 0.1338 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0061 0.0113
Echinococcus granulosus microtubule associated protein 2 0.0697 0.8548 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0061 0.0448
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.003 0.1017
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0049 0.0377 0.0441
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0077 0.0143
Echinococcus multilocularis microtubule associated protein 2 0.0697 0.8548 0.8548
Schistosoma mansoni hypothetical protein 0.0041 0.0281 0.0329
Echinococcus granulosus glutamate NMDA receptor subunit 0.0049 0.0377 0.0441
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0285 1
Brugia malayi Receptor family ligand binding region containing protein 0.0025 0.0077 0.0143
Mycobacterium ulcerans hypothetical protein 0.0024 0.0061 0.0448
Brugia malayi Receptor family ligand binding region containing protein 0.0025 0.0077 0.0143
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0297 0.3502 0.4097
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0061 0.0448
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0061 0.0113
Schistosoma mansoni hypothetical protein 0.0049 0.0377 0.0441
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0344 0.0403
Brugia malayi Glutamate receptor 1 precursor 0.0049 0.0377 0.0698
Echinococcus multilocularis NMDA receptor 0.0049 0.0377 0.0377
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0074 0.0692 0.081
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0002 0.0002
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0453 0.0839
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0369 0.0432
Loa Loa (eye worm) glutamate receptor 0.0025 0.0077 0.0143
Echinococcus multilocularis glutamate receptor NMDA 0.0518 0.6291 0.6291
Schistosoma mansoni hypothetical protein 0.0041 0.0276 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0158 0.5516
Loa Loa (eye worm) hypothetical protein 0.0088 0.0874 0.1619
Brugia malayi hypothetical protein 0.0088 0.0874 0.1619
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0158 0.5516
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0061 0.0448
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0061 0.0597
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0125 0.1338 1
Brugia malayi polk-prov protein 0.0031 0.0158 0.0292
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0194 0.2204 0.2204
Loa Loa (eye worm) hypothetical protein 0.0055 0.0453 0.0839
Loa Loa (eye worm) hypothetical protein 0.0041 0.0281 0.052
Echinococcus granulosus glutamate receptor 2 0.0074 0.0692 0.081
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0002 0.0004
Onchocerca volvulus 0.0025 0.0077 0.0143
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0521 0.0965
Echinococcus multilocularis protein patched 0.0042 0.0295 0.0295
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0369 0.0432
Brugia malayi hypothetical protein 0.0447 0.5401 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0285 1
Brugia malayi CHE-14 protein 0.0042 0.0295 0.0547
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0001 0.5
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0125 0.1338 1
Schistosoma mansoni glutamate receptor kainate 0.0049 0.0377 0.0441
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0295 0.0295
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0285 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.003 0.3806
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0061 0.0597
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0049 0.0377 0.0377
Schistosoma mansoni hypothetical protein 0.0041 0.0276 0.0323
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0344 0.0637
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0285 0.964
Loa Loa (eye worm) hypothetical protein 0.0447 0.5401 1
Brugia malayi Guanylyl cyclase protein 23 0.0025 0.0077 0.0143
Schistosoma mansoni ap endonuclease 0.0019 0.0001 0.0002
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0061 0.0448
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0002 0.0002
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0049 0.0377 0.0441
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0344 0.0637
Echinococcus granulosus metabotropic glutamate receptor 2 0.0025 0.0077 0.009
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0061 0.0597
Echinococcus multilocularis glutamate receptor 2 0.0049 0.0377 0.0377
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0125 0.1338 1
Entamoeba histolytica hypothetical protein 0.0025 0.0077 0.0755
Brugia malayi Metabotropic glutamate receptor precursor. 0.0025 0.0077 0.0143
Echinococcus multilocularis receptor type guanylyl cyclase 0.0025 0.0077 0.0077
Schistosoma mansoni metabotropic glutamate receptor 0.0025 0.0077 0.009
Loa Loa (eye worm) hypothetical protein 0.0447 0.5401 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0369 0.0684
Schistosoma mansoni patched 1 0.0042 0.0295 0.0345
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0143
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0143
Echinococcus granulosus glutamate receptor 2 0.0025 0.0077 0.009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0158 0.0292
Loa Loa (eye worm) hypothetical protein 0.006 0.0521 0.0965
Schistosoma mansoni glutamate receptor NMDA 0.0592 0.7221 0.8448
Echinococcus multilocularis GPCR, family 2 0.0019 0.0002 0.0002
Echinococcus granulosus glutamate receptor subunit protein glur 0.0049 0.0377 0.0441
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0344 0.0403
Echinococcus multilocularis Protein lozenge 0.0056 0.0469 0.0469
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0061 0.0113
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0061 0.0448
Onchocerca volvulus 0.0048 0.0369 0.0684
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.1005 0.1005
Trypanosoma brucei unspecified product 0.0035 0.0201 0.7036
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0025 0.0077 0.0143
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0521 0.0965
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0025 0.0077 0.0143
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0143
Schistosoma mansoni ATP-binding cassette transporter 0.0049 0.0377 0.0441
Schistosoma mansoni hypothetical protein 0.0019 0.0002 0.0002
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0049 0.0377 0.0377
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0001 0.5
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0074 0.0692 0.0692
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0061 0.7904
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0194 0.2204 0.2578
Echinococcus multilocularis glutamate receptor 2 0.0074 0.0692 0.0692
Echinococcus granulosus tyrosine kinase 0.0025 0.0077 0.009
Echinococcus granulosus dna polymerase kappa 0.0041 0.0285 0.0333
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.003 0.0216
Loa Loa (eye worm) RGC/RGC protein kinase 0.0025 0.0077 0.0143
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0285 0.212
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0049 0.0377 0.0377
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0042 0.0295 0.0547
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0344 0.0403
Loa Loa (eye worm) glutamate receptor 2 0.0049 0.0377 0.0698
Leishmania major DNA polymerase kappa, putative 0.0021 0.003 0.3806
Schistosoma mansoni tyrosine kinase 0.0025 0.0077 0.009
Echinococcus granulosus glutamate receptor NMDA 0.0518 0.6291 0.736
Echinococcus granulosus metabotropic glutamate receptor 5 0.0025 0.0077 0.009
Brugia malayi metabotropic glutamate receptor type 2 0.0025 0.0077 0.0143
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0001 0.5
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0369 0.0684
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0025 0.0077 0.0077
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0453 0.053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0143
Echinococcus granulosus nmda type glutamate receptor 0.0691 0.8482 0.9923
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0369 0.0369
Echinococcus granulosus nmda type glutamate receptor 0.0543 0.6607 0.7729
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0285 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0077 0.0143
Echinococcus multilocularis nmda type glutamate receptor 0.0543 0.6607 0.6607
Giardia lamblia DINP protein human, muc B family 0.0021 0.003 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0285 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0453 0.0453
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0201 0.7036
Schistosoma mansoni hypothetical protein 0.0019 0.0002 0.0002
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0453 0.053
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0285 0.0285
Schistosoma mansoni hypothetical protein 0.0019 0.0002 0.0002
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0125 0.1338 1
Echinococcus granulosus expressed conserved protein 0.0093 0.093 0.1087
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0001 0.0002
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0295 0.0547

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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