Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma brucei | hexokinase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | tubulin alpha chain, putative | 0.0072 | 0.6152 | 0.5783 |
Leishmania major | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.6152 | 0.6152 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0072 | 0.6152 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0096 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0072 | 0.6152 | 1 |
Leishmania major | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Leishmania major | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0072 | 0.6152 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0072 | 0.6152 | 0.6152 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0072 | 0.6152 | 0.5783 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0072 | 0.6152 | 0.5783 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0072 | 0.6152 | 0.5783 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0055 | 0.3481 | 0.3481 |
Leishmania major | hexokinase, putative | 0.0096 | 1 | 1 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0072 | 0.6152 | 0.5783 |
Trypanosoma cruzi | hexokinase, putative | 0.0096 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0055 | 0.3481 | 0.3481 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0055 | 0.3481 | 0.3481 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0039 | 0.0873 | 0.0873 |
Leishmania major | hexokinase, putative | 0.0096 | 1 | 1 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0072 | 0.6152 | 0.5783 |
Schistosoma mansoni | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Loa Loa (eye worm) | hexokinase | 0.0096 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0096 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Leishmania major | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Loa Loa (eye worm) | alpha-tubulin | 0.0072 | 0.6152 | 0.6152 |
Loa Loa (eye worm) | BEN-1 protein | 0.0039 | 0.0873 | 0.0873 |
Schistosoma mansoni | hexokinase | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0072 | 0.6152 | 0.6152 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0072 | 0.6152 | 1 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0072 | 0.6152 | 1 |
Leishmania major | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0072 | 0.6152 | 0.5783 |
Echinococcus multilocularis | tubulin alpha chain | 0.0072 | 0.6152 | 0.5783 |
Plasmodium falciparum | hexokinase | 0.0096 | 1 | 1 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0072 | 0.6152 | 0.5783 |
Trypanosoma brucei | hexokinase | 0.0096 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Plasmodium falciparum | alpha tubulin 2 | 0.0072 | 0.6152 | 0.5783 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.005 | 0.2671 | 0.3406 |
Loa Loa (eye worm) | alpha-tubulin | 0.0072 | 0.6152 | 0.6152 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0072 | 0.6152 | 0.5783 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0072 | 0.6152 | 0.5783 |
Brugia malayi | Hexokinase family protein | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0039 | 0.0873 | 0.0873 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0055 | 0.3481 | 0.494 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0072 | 0.6152 | 0.5783 |
Giardia lamblia | Alpha-tubulin | 0.0072 | 0.6152 | 1 |
Loa Loa (eye worm) | tubulin alpha-3 chain | 0.005 | 0.2671 | 0.2671 |
Leishmania major | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0072 | 0.6152 | 0.5783 |
Loa Loa (eye worm) | BEN-1 protein | 0.0039 | 0.0873 | 0.0873 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0072 | 0.6152 | 0.5783 |
Brugia malayi | Tubulin alpha chain | 0.0072 | 0.6152 | 0.5783 |
Echinococcus granulosus | tubulin alpha chain | 0.0072 | 0.6152 | 0.5783 |
Loa Loa (eye worm) | hexokinase | 0.006 | 0.4307 | 0.4307 |
Trypanosoma brucei | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Leishmania major | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Brugia malayi | Hexokinase family protein | 0.006 | 0.4307 | 0.3762 |
Loa Loa (eye worm) | tubulin beta chain | 0.0039 | 0.0873 | 0.0873 |
Brugia malayi | tubulin alpha-2 chain | 0.0072 | 0.6152 | 0.5783 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0072 | 0.6152 | 0.5783 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0072 | 0.6152 | 0.5783 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0072 | 0.6152 | 0.5783 |
Giardia lamblia | Alpha-tubulin | 0.0072 | 0.6152 | 1 |
Echinococcus multilocularis | tubulin alpha chain | 0.0072 | 0.6152 | 0.5783 |
Echinococcus granulosus | tubulin subunit TubB | 0.0072 | 0.6152 | 0.5783 |
Trypanosoma brucei | hexokinase, putative | 0.0096 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0096 | 1 | 1 |
Schistosoma mansoni | tubulin subunit alpha | 0.0072 | 0.6152 | 0.5783 |
Echinococcus multilocularis | hypothetical protein | 0.0072 | 0.6152 | 0.5783 |
Brugia malayi | alpha-tubulin | 0.0072 | 0.6152 | 0.5783 |
Echinococcus granulosus | tubulin alpha chain | 0.0072 | 0.6152 | 0.5783 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0072 | 0.6152 | 1 |
Trypanosoma brucei | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Brugia malayi | tubulin alpha chain - mouse | 0.0072 | 0.6152 | 0.5783 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0072 | 0.6152 | 0.5783 |
Echinococcus multilocularis | tubulin alpha chain | 0.0072 | 0.6152 | 0.5783 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0072 | 0.6152 | 0.5783 |
Echinococcus granulosus | hexokinase type 2 | 0.0096 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0096 | 1 | 1 |
Echinococcus granulosus | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0072 | 0.6152 | 0.5783 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0072 | 0.6152 | 0.5783 |
Plasmodium falciparum | alpha tubulin 1 | 0.0072 | 0.6152 | 0.5783 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0072 | 0.6152 | 0.5783 |
Echinococcus granulosus | tubulin alpha chain | 0.0072 | 0.6152 | 0.5783 |
Brugia malayi | Tubulin alpha-2 chain | 0.0072 | 0.6152 | 0.5783 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2671 | 0.2671 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0072 | 0.6152 | 0.5783 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0072 | 0.6152 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0096 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Echinococcus multilocularis | tubulin alpha chain | 0.0072 | 0.6152 | 0.5783 |
Leishmania major | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.5143 | 0.5143 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.3481 | 0.3481 |
Onchocerca volvulus | 0.0096 | 1 | 1 | |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0039 | 0.0873 | 0.0873 |
Echinococcus granulosus | tubulin alpha chain | 0.0072 | 0.6152 | 0.5783 |
Loa Loa (eye worm) | hexokinase type II | 0.0096 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0039 | 0.0873 | 0.0873 |
Schistosoma mansoni | tubulin subunit alpha | 0.0072 | 0.6152 | 0.5783 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0072 | 0.6152 | 1 |
Trypanosoma brucei | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Schistosoma mansoni | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Leishmania major | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0072 | 0.6152 | 0.5783 |
Toxoplasma gondii | hexokinase | 0.0096 | 1 | 1 |
Trypanosoma brucei | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0072 | 0.6152 | 0.6152 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0072 | 0.6152 | 0.5783 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0072 | 0.6152 | 1 |
Echinococcus granulosus | tubulin alpha chain | 0.0072 | 0.6152 | 0.5783 |
Loa Loa (eye worm) | beta-tubulin | 0.0039 | 0.0873 | 0.0873 |
Schistosoma mansoni | alpha tubulin | 0.0072 | 0.6152 | 0.5783 |
Plasmodium vivax | hexokinase, putative | 0.0096 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0096 | 1 | 0.5 |
Brugia malayi | Tubulin alpha-2 chain | 0.0072 | 0.6152 | 0.5783 |
Echinococcus multilocularis | tubulin alpha chain | 0.0072 | 0.6152 | 0.5783 |
Schistosoma mansoni | tubulin subunit alpha | 0.0072 | 0.6152 | 0.5783 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 10.321 uM | PUBCHEM_BIOASSAY: Confirmation assay for inhibitors of Trypanosoma brucei hexokinase 1-Analogue-first series. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1430, AID1632, AID2516, AID2560, AID2579, AID2600, AID449725, AID492951] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.