Detailed information for compound 1529477

Basic information

Technical information
  • TDR Targets ID: 1529477
  • Name: 6-methoxy-1-[(4-methoxyphenyl)methyl]-3-[(2-p henylpropylamino)methyl]indole-2-carboxylic a cid
  • MW: 458.549 | Formula: C28H30N2O4
  • H donors: 2 H acceptors: 2 LogP: 2.77 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)n(Cc1ccc(cc1)OC)c(c2CNCC(c1ccccc1)C)C(=O)O
  • InChi: 1S/C28H30N2O4/c1-19(21-7-5-4-6-8-21)16-29-17-25-24-14-13-23(34-3)15-26(24)30(27(25)28(31)32)18-20-9-11-22(33-2)12-10-20/h4-15,19,29H,16-18H2,1-3H3,(H,31,32)
  • InChiKey: JORNPOOTQDXQQV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-methoxy-1-[(4-methoxyphenyl)methyl]-3-[(2-phenylpropylamino)methyl]-2-indolecarboxylic acid
  • 6-methoxy-1-(4-methoxybenzyl)-3-[(2-phenylpropylamino)methyl]indole-2-carboxylic acid
  • E518-0779
  • NCGC00122066-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0182 0.2387
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0307
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Schistosoma mansoni neuropeptide receptor 0.0051 0.0367 0.0354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0274 0.556
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0051 0.0367 0.1479
Brugia malayi Glutamate receptor 2 precursor 0.0055 0.0415 0.1675
Echinococcus multilocularis serotonin receptor 0.0051 0.0367 0.0266
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0422
Brugia malayi G protein-coupled receptor 0.0051 0.0367 0.1479
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0055 0.0415 0.0314
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0367 0.0354
Echinococcus granulosus fmrfamide receptor 0.0051 0.0367 0.0301
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0051 0.0367 0.1489
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0274 0.0548
Onchocerca volvulus 0.0051 0.0367 1
Brugia malayi hypothetical protein 0.0051 0.0367 0.1479
Brugia malayi Dopamine receptor 0.0051 0.0367 0.1479
Onchocerca volvulus 0.0051 0.0367 1
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.2464 0.2704
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0402 0.0301
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0402 0.0341
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0051 0.0367 0.0266
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0142 0.1413 1
Schistosoma mansoni neuropeptide F-like receptor 0.0051 0.0367 0.0354
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0072 0.0113
Onchocerca volvulus 0.0051 0.0367 1
Schistosoma mansoni myosin xvIII 0.0051 0.0367 0.0354
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0084 0.0743 0.0645
Giardia lamblia GTOR 0.0054 0.0402 0.5
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0028 0.0104 0.0422
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0084 0.0743 0.0732
Schistosoma mansoni amine GPCR 0.0051 0.0367 0.0354
Echinococcus multilocularis neuropeptide receptor 0.0051 0.0367 0.0266
Schistosoma mansoni growth hormone secretagogue receptor 0.0051 0.0367 0.0354
Echinococcus granulosus glutamate NMDA receptor subunit 0.0055 0.0415 0.0357
Brugia malayi sulfakinin receptor protein 0.0051 0.0367 0.1479
Loa Loa (eye worm) G-protein coupled receptor 0.0051 0.0367 0.1489
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0051 0.0367 0.1489
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Loa Loa (eye worm) hypothetical protein 0.0108 0.1018 0.4131
Echinococcus granulosus expressed conserved protein 0.0101 0.0943 0.0961
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0051 0.0367 0.0354
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.3209 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0422
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0367 0.0354
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0114 0.0018
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0367 0.0266
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0198 0.2052 0.1969
Echinococcus multilocularis glutamate receptor 2 0.0055 0.0415 0.0314
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0259 0.05
Echinococcus multilocularis dro:myosuppressin receptor 0.0051 0.0367 0.0266
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Echinococcus granulosus g protein coupled receptor 0.0051 0.0367 0.0301
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0367 0.0266
Schistosoma mansoni biogenic amine (5HT) receptor 0.0051 0.0367 0.0354
Echinococcus granulosus dro:myosuppressin receptor 0.0051 0.0367 0.0301
Schistosoma mansoni amine GPCR 0.0051 0.0367 0.0354
Schistosoma mansoni glutamate receptor kainate 0.0055 0.0415 0.0419
Schistosoma mansoni opsin-like receptor 0.0051 0.0367 0.0354
Onchocerca volvulus Neuropeptide F receptor homolog 0.0051 0.0367 1
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.3209 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0051 0.0367 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Echinococcus granulosus g-protein coupled receptor 0.0051 0.0367 0.0301
Echinococcus granulosus serotonin receptor 0.0051 0.0367 0.0301
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0274 0.075
Echinococcus granulosus hypothetical protein 0.0051 0.0367 0.0301
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0127 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.3209 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Echinococcus multilocularis neuropeptide receptor A26 0.0051 0.0367 0.0266
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0051 0.0367 0.0354
Brugia malayi G-protein coupled receptor 0.0051 0.0367 0.1479
Brugia malayi Tachykinin-like peptides receptor 99D 0.0051 0.0367 0.1479
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0055 0.0415 0.0314
Echinococcus multilocularis neuropeptide s receptor 0.0051 0.0367 0.0266
Brugia malayi hypothetical protein 0.0051 0.0367 0.1479
Onchocerca volvulus 0.0051 0.0367 1
Echinococcus granulosus glutamate receptor NMDA 0.0589 0.6558 0.7393
Brugia malayi AKH receptor 0.0051 0.0367 0.1479
Brugia malayi Dopamine receptor protein 2 0.0051 0.0367 0.1479
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Echinococcus granulosus neuropeptide Y receptor 0.0051 0.0367 0.0301
Echinococcus multilocularis NMDA receptor 0.0055 0.0415 0.0314
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0259 0.05
Schistosoma mansoni amine GPCR 0.0051 0.0367 0.0354
Echinococcus multilocularis sex peptide receptor 0.0051 0.0367 0.0266
Chlamydia trachomatis glutamine binding protein 0.0142 0.1413 1
Schistosoma mansoni glutamate receptor NMDA 0.0055 0.0415 0.0419
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0367 0.0301
Brugia malayi CHE-14 protein 0.0046 0.0309 0.1245
Echinococcus granulosus neuropeptide receptor A26 0.0051 0.0367 0.0301
Echinococcus multilocularis glutamate receptor NMDA 0.0589 0.6558 0.6522
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0076 0.0477
Brugia malayi follicle stimulating hormone receptor 0.0051 0.0367 0.1479
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0076 0.0477
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0402 0.1041
Echinococcus granulosus alpha 1A adrenergic receptor 0.0051 0.0367 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0241 0.444
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1401 0.423
Echinococcus multilocularis neuropeptides capa receptor 0.0051 0.0367 0.0266
Brugia malayi Receptor family ligand binding region containing protein 0.0028 0.0104 0.0411
Echinococcus multilocularis fmrfamide receptor 0.0051 0.0367 0.0266
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0051 0.0367 0.0301
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0422
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0367 0.0301
Echinococcus granulosus G protein coupled receptor 139 0.0051 0.0367 0.0301
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0402 0.1152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0146 0.1138
Brugia malayi Glutamate receptor 1 precursor 0.0055 0.0415 0.1675
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0367 0.0354
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0084 0.0743 0.0732
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0076 0.0295
Onchocerca volvulus 0.0051 0.0367 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0274 0.556
Schistosoma mansoni hypothetical protein 0.0045 0.029 0.0251
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0367 0.0266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0367 0.0354
Brugia malayi GnHR receptor homolog 0.0051 0.0367 0.1479
Brugia malayi hypothetical protein 0.0051 0.0367 0.1479
Schistosoma mansoni ATP-binding cassette transporter 0.0055 0.0415 0.0419
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0367 0.0266
Mycobacterium ulcerans hypothetical protein 0.0157 0.1585 1
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0028 0.0104 0.0411
Echinococcus multilocularis fmrfamide receptor 0.0051 0.0367 0.0266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0367 0.0354
Brugia malayi hypothetical protein 0.0096 0.0888 0.3594
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0055 0.0415 0.0314
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Schistosoma mansoni neuropeptide F-like receptor 0.0051 0.0367 0.0354
Schistosoma mansoni eyes absent homolog 0.0096 0.0888 0.1056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0402 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0051 0.0367 0.0266
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0051 0.0367 0.0354
Schistosoma mansoni glutamate receptor kainate 0.0055 0.0415 0.0419
Echinococcus multilocularis neuropeptide receptor 0.0051 0.0367 0.0266
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0055 0.0415 0.0357
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Schistosoma mansoni glutamate receptor kainate 0.0055 0.0415 0.0419
Echinococcus granulosus glutamate receptor 2 0.0084 0.0743 0.0732
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0309 0.0235
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0051 0.0367 0.0301
Brugia malayi hypothetical protein 0.0051 0.0367 0.1479
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0402 0.0959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0146 0.1138
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0051 0.0367 0.1479
Echinococcus granulosus 7TM GPCR rhodopsin 0.0051 0.0367 0.0301
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0422
Echinococcus multilocularis neuropeptide Y receptor 0.0051 0.0367 0.0266
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0309 0.0207
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0051 0.0367 0.0266
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0325 0.1308
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0367 0.0354
Schistosoma mansoni biogenic amine (5HT) receptor 0.0051 0.0367 0.0354
Brugia malayi hypothetical protein 0.0051 0.0367 0.1479
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.1037 0.1258
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0367 0.0301
Echinococcus granulosus glutamate receptor subunit protein glur 0.0055 0.0415 0.0357
Schistosoma mansoni opsin-like receptor 0.0051 0.0367 0.0354
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0051 0.0367 0.1479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.015 0.1267
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0367 0.0354
Echinococcus multilocularis allatostatin A receptor 0.0051 0.0367 0.0266
Loa Loa (eye worm) hypothetical protein 0.0096 0.0888 0.3602
Loa Loa (eye worm) melatonin receptor type 1A 0.0051 0.0367 0.1489
Schistosoma mansoni hypothetical protein 0.0045 0.029 0.0251
Brugia malayi metabotropic glutamate receptor type 2 0.0028 0.0104 0.0411
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Echinococcus multilocularis somatostatin receptor 0.0051 0.0367 0.0266
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0051 0.0367 0.0354
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Schistosoma mansoni glutamate receptor AMPA 0.0055 0.0415 0.0419
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.1018 0.0923
Brugia malayi hypothetical protein 0.0233 0.2464 1
Schistosoma mansoni glutamate receptor AMPA 0.0055 0.0415 0.0419
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0076 0.0477
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0367 0.0301
Echinococcus multilocularis protein patched 0.0046 0.0309 0.0207
Echinococcus multilocularis protein dispatched 1 0.0053 0.0385 0.0284
Echinococcus granulosus orexin receptor type 2 0.0051 0.0367 0.0301
Onchocerca volvulus 0.0051 0.0367 1
Onchocerca volvulus 0.0051 0.0367 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0051 0.0367 0.0354
Brugia malayi Dopamine receptor protein 1 0.0051 0.0367 0.1479
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0051 0.0367 0.0354
Echinococcus multilocularis orexin receptor type 2 0.0051 0.0367 0.0266
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Leishmania major extracellular receptor, putative 0.0028 0.0104 0.0091
Leishmania major hypothetical protein, conserved 0.003 0.0127 0.0165
Schistosoma mansoni hypothetical protein 0.0051 0.0367 0.0354
Schistosoma mansoni hypothetical protein 0.0051 0.0367 0.0354
Schistosoma mansoni neuropeptide receptor 0.0051 0.0367 0.0354
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0051 0.0367 0.0266
Onchocerca volvulus 0.0051 0.0367 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0241 0.5628
Brugia malayi G protein-coupled receptor F59B2.13 0.0051 0.0367 0.1479
Echinococcus multilocularis g-protein coupled receptor 0.0051 0.0367 0.0266
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0076 0.0477
Schistosoma mansoni neuropeptide f receptor 76f 0.0051 0.0367 0.0354
Echinococcus granulosus 7tm_1 domain containing protein 0.0051 0.0367 0.0301
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0402 0.0959
Echinococcus multilocularis nmda type glutamate receptor 0.0786 0.8833 0.8821
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0402 1
Brugia malayi ORL1-like opioid receptor 0.0051 0.0367 0.1479
Echinococcus granulosus nmda type glutamate receptor 0.0786 0.8833 1
Echinococcus granulosus g protein coupled receptor 0.0051 0.0367 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0241 0.444
Echinococcus granulosus sex peptide receptor 0.0051 0.0367 0.0301
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0422
Onchocerca volvulus 0.0051 0.0367 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1401 0.4177
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0367 0.0301
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0051 0.0367 0.0266
Echinococcus granulosus neuropeptide s receptor 0.0051 0.0367 0.0301
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0402 0.163
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0055 0.0415 0.0357
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0422
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0241 0.444
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0051 0.0367 0.0354
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0051 0.0367 0.0266
Echinococcus multilocularis neuropeptide Y receptor 0.0051 0.0367 0.0266
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Echinococcus granulosus Niemann Pick C1 protein 0.0154 0.1551 0.1657
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0028 0.0104 0.0977
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0367 0.0266
Loa Loa (eye worm) hypothetical protein 0.0233 0.2464 1
Brugia malayi larval opioid receptor 0.0051 0.0367 0.1479
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0402 0.1152
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Schistosoma mansoni neuropeptide receptor 0.0051 0.0367 0.0354
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Loa Loa (eye worm) RGC/RGC protein kinase 0.0028 0.0104 0.0422
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0028 0.0104 0.0422
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0241 0.444
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0307
Onchocerca volvulus 0.0051 0.0367 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0051 0.0367 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0274 0.556
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0114 0.0018
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0051 0.0367 0.1489
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0422
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0367 0.0354
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0367 0.0266
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0051 0.0367 0.0266
Onchocerca volvulus 0.0051 0.0367 1
Schistosoma mansoni amine GPCR 0.0051 0.0367 0.0354
Echinococcus granulosus biogenic amine 5HT receptor 0.0051 0.0367 0.0301
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Onchocerca volvulus 0.0051 0.0367 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0309 0.1255
Onchocerca volvulus 0.0028 0.0104 0.0977
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0402 0.346
Echinococcus granulosus biogenic amine 5HT receptor 0.0051 0.0367 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0309 0.6795
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0055 0.0415 0.0357
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0367 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0114 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0241 0.444
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0367 0.0266
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0259 0.0703
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0274 0.0634
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0051 0.0367 0.0266
Brugia malayi hypothetical protein 0.0051 0.0367 0.1479
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0142 0.1413 0.5
Echinococcus granulosus neuropeptide receptor 0.0051 0.0367 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.031 0.6827
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.015 0.1267
Brugia malayi neuropeptide F receptor 0.0051 0.0367 0.1479
Brugia malayi hypothetical protein 0.003 0.0127 0.0505
Schistosoma mansoni survival motor neuron protein 0.0048 0.0325 0.0298
Schistosoma mansoni opsin-like receptor 0.0051 0.0367 0.0354
Echinococcus multilocularis G-protein coupled receptor, putative 0.0051 0.0367 0.0266
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0367 0.0266
Brugia malayi Metabotropic glutamate receptor precursor. 0.0028 0.0104 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0274 0.556
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0402 0.346
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.3209 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0076 0.0477
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0127 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0367 0.0354
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0142 0.1413 0.892
Schistosoma mansoni histamine h1 receptor 0.0051 0.0367 0.0354
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0084 0.0743 0.0732
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0084 0.0743 0.0645
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Echinococcus multilocularis serotonin receptor 0.0051 0.0367 0.0266
Onchocerca volvulus 0.0028 0.0104 0.0977
Loa Loa (eye worm) hypothetical protein 0.003 0.0127 0.0516
Brugia malayi hypothetical protein 0.0051 0.0367 0.1479
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0051 0.0367 0.1479
Loa Loa (eye worm) neuropeptide F receptor 0.0051 0.0367 0.1489
Echinococcus multilocularis nmda type glutamate receptor 0.0617 0.6885 0.6852
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0309 0.0235
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0422
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0367 0.0301
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0051 0.0367 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0241 0.444
Echinococcus granulosus allatostatin A receptor 0.0051 0.0367 0.0301
Schistosoma mansoni adenoreceptor 0.0051 0.0367 0.0354
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.1018 0.4124
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0076 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0114 0.0018
Echinococcus multilocularis neuropeptides capa receptor 0.0051 0.0367 0.0266
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0076 0.5
Schistosoma mansoni hypothetical protein 0.0045 0.029 0.0251
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0051 0.0367 0.0354
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Schistosoma mansoni alpha-1 adrenergic receptor 0.0051 0.0367 0.0354
Schistosoma mansoni neuropeptide receptor 0.0051 0.0367 0.0354
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0367 0.0301
Brugia malayi putative neuropeptide receptor NPR1 0.0051 0.0367 0.1479
Brugia malayi G-protein coupled receptor 0.0051 0.0367 0.1479
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0127 0.0287
Brugia malayi putative neuropeptide receptor 0.0051 0.0367 0.1479
Schistosoma mansoni biogenic amine receptor 0.0051 0.0367 0.0354
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0084 0.0743 0.0732
Brugia malayi Serotonin receptor 0.0051 0.0367 0.1479
Loa Loa (eye worm) G-protein coupled receptor 0.0051 0.0367 0.1489
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0367 0.0266
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0055 0.0415 0.0314
Entamoeba histolytica hypothetical protein 0.0028 0.0104 0.0302
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Brugia malayi Guanylyl cyclase protein 23 0.0028 0.0104 0.0411
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Brugia malayi RE15519p 0.0051 0.0367 0.1479
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0259 0.05
Brugia malayi neuropeptide F receptor 0.0051 0.0367 0.1479
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0084 0.0743 0.0645
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0422
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0051 0.0367 0.0301
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0076 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.015 0.1267
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0051 0.0367 0.1479
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0367 0.0266
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0076 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0051 0.0367 0.0266
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Schistosoma mansoni patched 1 0.0046 0.0309 0.0277
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.1018 1
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0367 0.0301
Echinococcus granulosus neuropeptides capa receptor 0.0051 0.0367 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0241 0.444
Schistosoma mansoni biogenic amine receptor 0.0051 0.0367 0.0354
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0127 0.0075
Echinococcus granulosus tachykinin peptides receptor 99D 0.0051 0.0367 0.0301
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0127 0.0075
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0367 0.0354
Echinococcus granulosus g protein coupled receptor 0.0051 0.0367 0.0301
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0051 0.0367 0.0266
Loa Loa (eye worm) hypothetical protein 0.0046 0.0309 0.1255
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0367 0.0301
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.1401 0.4302
Brugia malayi Melatonin receptor type 1A 0.0051 0.0367 0.1479
Brugia malayi hypothetical protein 0.0051 0.0367 0.1479
Onchocerca volvulus 0.0051 0.0367 1
Schistosoma mansoni hypothetical protein 0.0055 0.0415 0.0419
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0127 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0307
Toxoplasma gondii hypothetical protein 0.0048 0.033 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0051 0.0367 0.0301
Schistosoma mansoni hypothetical protein 0.0051 0.0367 0.0354
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0402 0.0401
Loa Loa (eye worm) RGC/RGC protein kinase 0.0028 0.0104 0.0422
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.1018 0.1047
Loa Loa (eye worm) glutamate receptor 2 0.0055 0.0415 0.1685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0274 0.556
Brugia malayi hypothetical protein 0.0051 0.0367 0.1479
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0367 0.0354
Onchocerca volvulus 0.0051 0.0367 1
Schistosoma mansoni hypothetical protein 0.0045 0.029 0.0251
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Echinococcus multilocularis G protein coupled receptor 139 0.0051 0.0367 0.0266
Echinococcus granulosus neuropeptides capa receptor 0.0051 0.0367 0.0301
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0051 0.0367 0.1489
Loa Loa (eye worm) hypothetical protein 0.0057 0.0429 0.1742
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1585 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Echinococcus multilocularis glutamate receptor 2 0.0084 0.0743 0.0645
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0142 0.1413 0.892
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0051 0.0367 0.0354
Loa Loa (eye worm) hypothetical protein 0.0096 0.0888 0.3602
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Echinococcus granulosus neuropeptide Y receptor 0.0051 0.0367 0.0301
Echinococcus multilocularis Niemann Pick C1 protein 0.0154 0.1551 0.1462
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0196 0.2856
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0367 0.0301
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0076 0.0295
Brugia malayi Receptor family ligand binding region containing protein 0.0028 0.0104 0.0411
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0367 0.0354
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0051 0.0367 0.1489
Schistosoma mansoni glutamate receptor NMDA 0.0673 0.7524 1
Loa Loa (eye worm) glutamate receptor 0.0028 0.0104 0.0422
Echinococcus granulosus somatostatin receptor 0.0051 0.0367 0.0301
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0028 0.0104 0.0422
Echinococcus granulosus nmda type glutamate receptor 0.0617 0.6885 0.7768
Schistosoma mansoni hypothetical protein 0.0051 0.0367 0.0354
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0051 0.0367 0.0266
Loa Loa (eye worm) TYRA-2 protein 0.0051 0.0367 0.1489
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0051 0.0367 0.0354
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0142 0.1413 0.5
Mycobacterium ulcerans hypothetical protein 0.0026 0.0076 0.0477
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0367 0.0266
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.2464 0.2385
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0051 0.0367 0.0266
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0076 0.0477
Onchocerca volvulus 0.0048 0.0325 0.8552
Loa Loa (eye worm) RGC/RGC protein kinase 0.0028 0.0104 0.0422
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0367 0.0266
Onchocerca volvulus 0.0051 0.0367 1
Echinococcus multilocularis expressed conserved protein 0.0101 0.0943 0.0847
Schistosoma mansoni hypothetical protein 0.0048 0.0325 0.0298
Schistosoma mansoni amine GPCR 0.0051 0.0367 0.0354
Onchocerca volvulus 0.0051 0.0367 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0051 0.0367 0.0301
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Brugia malayi hypothetical protein 0.0028 0.0104 0.0411
Brugia malayi hypothetical protein 0.0051 0.0367 0.1479
Brugia malayi Serotonin receptor 0.0051 0.0367 0.1479
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0402 0.162
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0076 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0402 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0367 0.0266
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0365 0.084
Loa Loa (eye worm) hypothetical protein 0.0051 0.0367 0.1489
Echinococcus granulosus neuropeptide receptor 0.0051 0.0367 0.0301
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0051 0.0367 0.0301
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0402 0.1041
Schistosoma mansoni biogenic amine receptor 0.0051 0.0367 0.0354
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0084 0.0743 0.0645
Onchocerca volvulus 0.0051 0.0367 1
Loa Loa (eye worm) glutamate receptor 1 0.0055 0.0415 0.1685
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0076 0.0295
Loa Loa (eye worm) neuropeptide F receptor 0.0051 0.0367 0.1489

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.4816 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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