Detailed information for compound 1530980

Basic information

Technical information
  • TDR Targets ID: 1530980
  • Name: 3-(3-chlorophenyl)-1-ethyl-1-phenylurea
  • MW: 274.745 | Formula: C15H15ClN2O
  • H donors: 1 H acceptors: 1 LogP: 3.66 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccccc1)C(=O)Nc1cccc(c1)Cl
  • InChi: 1S/C15H15ClN2O/c1-2-18(14-9-4-3-5-10-14)15(19)17-13-8-6-7-12(16)11-13/h3-11H,2H2,1H3,(H,17,19)
  • InChiKey: OGZCCGLTBCWOKV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(3-chlorophenyl)-1-ethyl-1-phenyl-urea
  • 82744-90-9
  • MLS001000582
  • N'-(3-chlorophenyl)-N-ethyl-N-phenylurea
  • SMR000496097
  • NSC164139
  • ZINC00293095

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0205 1 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.8405 0.8405
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.1747 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.2218 0.2638
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3096 0.3096
Loa Loa (eye worm) RNA binding protein 0.0076 0.3096 0.3683
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.1747 0.5
Loa Loa (eye worm) TAR-binding protein 0.0076 0.3096 0.3683
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3096 0.3096
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.1747 0.1747
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.8405 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.1747 0.5
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.1516 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.1191 0.1417
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2218 0.2638
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.1747 0.5
Schistosoma mansoni hypothetical protein 0.0205 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2218 0.2638
Echinococcus multilocularis geminin 0.0205 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3096 0.3096
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.3096 0.3683
Echinococcus multilocularis tar DNA binding protein 0.0076 0.3096 0.3096
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.8405 0.8405
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.1516 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3096 0.3096
Schistosoma mansoni tar DNA-binding protein 0.0076 0.3096 0.3096
Schistosoma mansoni hypothetical protein 0.0041 0.1191 0.1191
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2218 0.2638
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.3096 0.3683
Brugia malayi TAR-binding protein 0.0076 0.3096 0.3683
Echinococcus granulosus tar DNA binding protein 0.0076 0.3096 0.3096
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.1516 0.5
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.1747 0.5
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.8141 0.8141
Brugia malayi RNA binding protein 0.0076 0.3096 0.3683
Loa Loa (eye worm) acetyltransferase 0.0175 0.8405 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1191 0.1417

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.6109 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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