Detailed information for compound 1531801

Basic information

Technical information
  • TDR Targets ID: 1531801
  • Name: 2-(2-oxochromen-7-yl)oxy-N-pyridin-3-ylacetam ide
  • MW: 296.277 | Formula: C16H12N2O4
  • H donors: 1 H acceptors: 3 LogP: 1.71 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccnc1)COc1ccc2c(c1)oc(=O)cc2
  • InChi: 1S/C16H12N2O4/c19-15(18-12-2-1-7-17-9-12)10-21-13-5-3-11-4-6-16(20)22-14(11)8-13/h1-9H,10H2,(H,18,19)
  • InChiKey: WTBFFQDOHNJKNZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(2-oxochromen-7-yl)oxy-N-(3-pyridyl)acetamide
  • 2-[(2-oxo-7-chromenyl)oxy]-N-(3-pyridyl)acetamide
  • 2-(2-ketochromen-7-yl)oxy-N-(3-pyridyl)acetamide
  • 2-(2-oxochromen-7-yl)oxy-N-pyridin-3-yl-ethanamide
  • ZINC06661639

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria Get druggable targets OG5_128068 All targets in OG5_128068
Mycobacterium tuberculosis Probable aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA Get druggable targets OG5_128068 All targets in OG5_128068
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA Get druggable targets OG5_128068 All targets in OG5_128068
Candida albicans second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Candida albicans adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria Get druggable targets OG5_128068 All targets in OG5_128068
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Candida albicans second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_128068 All targets in OG5_128068
Trichomonas vaginalis acetylornithine aminotransferase, putative Get druggable targets OG5_128068 All targets in OG5_128068
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 437 aa 397 aa 28.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.2029 0.2024
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.1201 0.1241
Plasmodium vivax ornithine aminotransferase, putative 0.0026 0.073 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.014 0.0145
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.014 0.0145
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0184 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.2029 0.6113
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.2029 0.6113
Schistosoma mansoni tar DNA-binding protein 0.0067 0.312 0.9645
Brugia malayi ecdysteroid receptor 0.0034 0.1201 0.116
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.1201 0.116
Brugia malayi steroid hormone receptor 0.0034 0.1201 0.116
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.1201 0.3432
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0865 0.0894
Brugia malayi hypothetical protein 0.0018 0.0254 0.0172
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.1201 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.1201 0.1241
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.1201 0.1241
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0254 0.0368
Schistosoma mansoni hypothetical protein 0.0043 0.1717 0.5104
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0254 0.0262
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.312 0.3226
Loa Loa (eye worm) hypothetical protein 0.0016 0.014 0.0145
Loa Loa (eye worm) hypothetical protein 0.0018 0.0254 0.0262
Loa Loa (eye worm) hypothetical protein 0.0034 0.1201 0.1241
Echinococcus multilocularis tar DNA binding protein 0.0067 0.312 0.3226
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.014 0.0054
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.1201 0.3432
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.1201 0.1241
Brugia malayi nuclear hormone receptor 0.0034 0.1201 0.116
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.323 0.2697
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.1201 0.1241
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.1201 0.1241
Loa Loa (eye worm) hypothetical protein 0.0016 0.014 0.0145
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0865 0.081
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.2029 0.2097
Loa Loa (eye worm) hypothetical protein 0.0016 0.014 0.0145
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.2029 0.2097
Loa Loa (eye worm) hypothetical protein 0.0018 0.0254 0.0262
Loa Loa (eye worm) hypothetical protein 0.0178 0.9672 1
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0026 0.073 0.5
Brugia malayi tailless protein 0.0016 0.014 0.0054
Schistosoma mansoni lamin 0.0028 0.0865 0.2346
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0254 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.1201 0.116
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.014 0.0145
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.2029 0.2097
Echinococcus granulosus ornithine aminotransferase 0.0026 0.073 0.0754
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.323 0.2697
Loa Loa (eye worm) hypothetical protein 0.0034 0.1201 0.1241
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.014 0.0145
Brugia malayi Nuclear hormone receptor E75 0.0016 0.014 0.0054
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.323 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.1201 0.116
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.1201 0.3432
Brugia malayi Nuclear hormone receptor E75 0.0016 0.014 0.0054
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.1201 0.3432
Loa Loa (eye worm) hypothetical protein 0.0016 0.014 0.0145
Loa Loa (eye worm) hypothetical protein 0.0016 0.014 0.0145
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0184 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.312 0.3163
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.1201 0.1241
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.014 0.0054
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.1201 0.3432
Loa Loa (eye worm) hypothetical protein 0.0016 0.014 0.0145
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.014 0.0145
Schistosoma mansoni tar DNA-binding protein 0.0067 0.312 0.9645
Loa Loa (eye worm) RNA binding protein 0.0067 0.312 0.3226
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.1201 0.3432
Entamoeba histolytica hypothetical protein 0.0043 0.1717 0.5
Schistosoma mansoni nuclear hormone receptor 0.0034 0.1201 0.3432
Entamoeba histolytica hypothetical protein 0.0043 0.1717 0.5
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0026 0.073 0.0669
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.014 0.0145
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.1201 0.3432
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.1201 0.1241
Onchocerca volvulus 0.0028 0.0865 0.6835
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.1201 0.1241
Echinococcus multilocularis Aminotransferase class III 0.0026 0.073 0.0754
Echinococcus granulosus Aminotransferase class III 0.0026 0.073 0.0754
Loa Loa (eye worm) hypothetical protein 0.0034 0.1201 0.1241
Schistosoma mansoni tar DNA-binding protein 0.0067 0.312 0.9645
Loa Loa (eye worm) TAR-binding protein 0.0067 0.312 0.3226
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.1201 0.1241
Schistosoma mansoni coup transcription factor 0.0034 0.1201 0.3432
Brugia malayi nuclear receptor NHR-67 0.0016 0.014 0.0054
Loa Loa (eye worm) hypothetical protein 0.0016 0.014 0.0145
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0089 0.0092
Brugia malayi hypothetical protein 0.0018 0.0254 0.0172
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0254 0.0262
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.1201 0.1241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.1201 0.1241
Echinococcus granulosus intermediate filament protein 0.0028 0.0865 0.0894
Loa Loa (eye worm) hypothetical protein 0.0016 0.014 0.0145
Brugia malayi Muscleblind-like protein 0.0178 0.9672 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0865 0.0894
Echinococcus multilocularis muscleblind protein 1 0.0178 0.9672 1
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0254 0.0172
Brugia malayi hypothetical protein 0.0016 0.014 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.014 0.0145
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.1201 0.1241
Brugia malayi TAR-binding protein 0.0067 0.312 0.3163
Loa Loa (eye worm) hypothetical protein 0.0034 0.1201 0.1241
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.1201 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.1717 0.1775
Entamoeba histolytica hypothetical protein 0.0043 0.1717 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.1201 0.116
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.1201 1
Brugia malayi hypothetical protein 0.0016 0.014 0.0054
Loa Loa (eye worm) hypothetical protein 0.0028 0.0834 0.0863
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.014 0.0145
Echinococcus granulosus muscleblind protein 0.0178 0.9672 1
Echinococcus granulosus lamin 0.0028 0.0865 0.0894
Brugia malayi ecdysone receptor 0.0016 0.014 0.0054
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0184 1 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0142 0.7568 0.7825
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.1201 0.1241
Loa Loa (eye worm) hypothetical protein 0.0016 0.014 0.0145
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.323 0.3339
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.1201 0.1241
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.1201 0.1241
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.1201 0.1241
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.1201 0.1241
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0254 0.0368
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.2029 0.6113
Brugia malayi nuclear receptor NHR-88 0.0016 0.014 0.0054
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.1201 0.116
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.1717 0.1775
Echinococcus multilocularis musashi 0.0028 0.0865 0.0894
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.014 0.0054
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.014 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.1201 0.1241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.1201 0.1241
Loa Loa (eye worm) hypothetical protein 0.0034 0.1201 0.1241
Loa Loa (eye worm) hypothetical protein 0.0178 0.9672 1
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.323 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.014 0.0145
Echinococcus multilocularis ornithine aminotransferase 0.0026 0.073 0.0754
Echinococcus multilocularis muscleblind protein 0.0178 0.9672 1
Brugia malayi nuclear hormone receptor 0.0016 0.014 0.0054
Loa Loa (eye worm) hypothetical protein 0.0016 0.014 0.0145
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.2029 0.2097
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.323 0.5
Echinococcus multilocularis ornithine aminotransferase 0.0026 0.073 0.0754
Mycobacterium ulcerans hypothetical protein 0.0184 1 1
Brugia malayi nuclear receptor RXR 0.0018 0.0254 0.0172
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.014 0.0145
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.1201 0.116
Entamoeba histolytica hypothetical protein 0.0043 0.1717 0.5
Schistosoma mansoni lamin 0.0028 0.0865 0.2346
Loa Loa (eye worm) hypothetical protein 0.0016 0.014 0.0145
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.1201 0.1241
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.1201 0.116
Schistosoma mansoni tar DNA-binding protein 0.0067 0.312 0.9645
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.014 0.0145
Schistosoma mansoni thyroid hormone receptor 0.0034 0.1201 0.3432
Brugia malayi conserved hypotetical protein 0.0016 0.014 0.0054
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.014 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.1201 0.116
Schistosoma mansoni thyroid hormone receptor 0.0034 0.1201 0.3432
Loa Loa (eye worm) hypothetical protein 0.0018 0.0254 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.1201 0.116
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.014 0.0145
Echinococcus multilocularis lamin 0.0028 0.0865 0.0894
Echinococcus granulosus tar DNA binding protein 0.0067 0.312 0.3226
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.323 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.1201 0.116
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.1201 0.116
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.1201 0.3432
Mycobacterium tuberculosis Probable aminotransferase 0.0184 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.323 0.2697
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.014 0.0054
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.1201 0.1241
Loa Loa (eye worm) MH2 domain-containing protein 0.0142 0.7568 0.7825
Echinococcus granulosus FTZ F1 alpha 0.0034 0.1201 0.1241
Brugia malayi nuclear receptor RXR 0.0016 0.014 0.0054
Echinococcus multilocularis lamin dm0 0.0028 0.0865 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.1201 0.116
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.1201 0.116
Loa Loa (eye worm) hypothetical protein 0.0018 0.0254 0.0262
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.1717 0.5104
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0026 0.073 0.5
Brugia malayi nuclear receptor NHR-88 0.0034 0.1201 0.116
Brugia malayi MH2 domain containing protein 0.0142 0.7568 0.7804
Brugia malayi RNA binding protein 0.0067 0.312 0.3163
Loa Loa (eye worm) hypothetical protein 0.0034 0.1201 0.1241
Onchocerca volvulus 0.0028 0.0865 0.6835
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.1201 0.1241
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.014 0.0145
Schistosoma mansoni intermediate filament proteins 0.0028 0.0865 0.2346
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.1201 0.3432
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.1201 0.1241
Loa Loa (eye worm) hypothetical protein 0.0034 0.1201 0.1241
Brugia malayi intermediate filament protein 0.0028 0.0865 0.081
Plasmodium falciparum ornithine aminotransferase 0.0026 0.073 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.1201 0.116
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.323 0.3339
Brugia malayi hypothetical protein 0.0043 0.1717 0.1699
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.323 0.2697
Loa Loa (eye worm) hypothetical protein 0.0028 0.0865 0.0894
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0026 0.073 0.1908
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.1201 0.116
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0254 0.0172
Schistosoma mansoni tar DNA-binding protein 0.0067 0.312 0.9645
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.2029 0.2097
Onchocerca volvulus 0.0034 0.1201 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0254 0.0262
Loa Loa (eye worm) DR-78 0.0016 0.014 0.0145
Loa Loa (eye worm) hypothetical protein 0.0034 0.1201 0.1241
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.1201 0.1241
Echinococcus granulosus lamin dm0 0.0028 0.0865 0.0894
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.014 0.0145
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.014 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.1201 0.116

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) 13.61 uM PubChem BioAssay. Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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