Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | integrin alpha ps | 0.0341 | 0.3074 | 0.5222 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0293 | 0.0293 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0102 | 0.0293 | 0.0369 |
Schistosoma mansoni | integrin alpha-ps | 0.0178 | 0.1175 | 0.1478 |
Echinococcus granulosus | integrin alpha ps | 0.0164 | 0.1011 | 0.1718 |
Echinococcus multilocularis | integrin alpha 3 | 0.0584 | 0.5887 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.1011 | 0.1272 |
Echinococcus multilocularis | integrin alpha ps | 0.0341 | 0.3074 | 0.5222 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0102 | 0.0293 | 0.0293 |
Echinococcus granulosus | integrin alpha 3 | 0.0584 | 0.5887 | 1 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.034 | 0.3062 | 0.3852 |
Loa Loa (eye worm) | hypothetical protein | 0.042 | 0.3988 | 0.3988 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0762 | 0.7949 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0102 | 0.0293 | 0.0369 |
Loa Loa (eye worm) | hypothetical protein | 0.034 | 0.3062 | 0.3062 |
Schistosoma mansoni | integrin alpha | 0.0762 | 0.7949 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0598 | 0.605 | 0.605 |
Echinococcus granulosus | integrin alpha ps | 0.0341 | 0.3074 | 0.5222 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.1175 | 0.1175 |
Schistosoma mansoni | integrin alpha-ps | 0.0341 | 0.3074 | 0.3867 |
Echinococcus multilocularis | integrin alpha ps | 0.0164 | 0.1011 | 0.1718 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.1011 | 0.1011 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.