Detailed information for compound 1537779

Basic information

Technical information
  • TDR Targets ID: 1537779
  • Name: N-[[5-[2-[(5-ethyl-1,3,4-thiadiazol-2-yl)amin o]-2-oxoethyl]sulfanyl-1,3,4-oxadiazol-2-yl]m ethyl]benzamide
  • MW: 404.467 | Formula: C16H16N6O3S2
  • H donors: 2 H acceptors: 6 LogP: 1.92 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1nnc(s1)NC(=O)CSc1nnc(o1)CNC(=O)c1ccccc1
  • InChi: 1S/C16H16N6O3S2/c1-2-13-20-21-15(27-13)18-11(23)9-26-16-22-19-12(25-16)8-17-14(24)10-6-4-3-5-7-10/h3-7H,2,8-9H2,1H3,(H,17,24)(H,18,21,23)
  • InChiKey: IAKFYAQTBITTQO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[5-[2-[(5-ethyl-1,3,4-thiadiazol-2-yl)amino]-2-oxo-ethyl]sulfanyl-1,3,4-oxadiazol-2-yl]methyl]benzamide
  • N-[[5-[[2-[(5-ethyl-1,3,4-thiadiazol-2-yl)amino]-2-oxoethyl]thio]-1,3,4-oxadiazol-2-yl]methyl]benzamide
  • N-[[5-[[2-[(5-ethyl-1,3,4-thiadiazol-2-yl)amino]-2-keto-ethyl]thio]-1,3,4-oxadiazol-2-yl]methyl]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0084 0.2954
Loa Loa (eye worm) sugar transporter 0.0104 0.216 0.3107
Brugia malayi hypothetical protein 0.0236 0.5212 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0532 0.0874
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1025 0.1488
Echinococcus granulosus General substrate transporter 0.009 0.1821 0.2648
Mycobacterium ulcerans sugar transporter 0.0015 0.0084 0.2954
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0235 0.0233
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0235 0.0152
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0202 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1025 0.1443
Loa Loa (eye worm) hypothetical protein 0.0236 0.5212 0.7581
Schistosoma mansoni hypothetical protein 0.0307 0.6861 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1025 0.1488
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0859 0.1512
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0084 0.0062
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0589 1
Schistosoma mansoni hypothetical protein 0.0169 0.3662 0.5333
Brugia malayi Cam kinase protein 1 0.0032 0.0484 0.078
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0283 0.0405
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0062
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.216 0.3143
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0469 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0062
Echinococcus granulosus geminin 0.0169 0.3662 0.5333
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0438 0.0631
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0493 0.1973
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0235 0.0334
Loa Loa (eye worm) hypothetical protein 0.0031 0.0469 0.0627
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0589 0.0779
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0484 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0062
Loa Loa (eye worm) hypothetical protein 0.0025 0.0333 0.0427
Loa Loa (eye worm) hypothetical protein 0.0034 0.0532 0.0719
Schistosoma mansoni hypothetical protein 0.0169 0.3662 0.5333
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0493 0.1973
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0484 0.0649
Schistosoma mansoni hypothetical protein 0.0016 0.0109 0.0151
Echinococcus granulosus importin subunit beta 1 0.0029 0.0411 0.0591
Schistosoma mansoni sugar transporter 0.0015 0.0084 0.0114
Schistosoma mansoni sugar transporter 0.0015 0.0084 0.0114
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0327 0.481
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0484 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0062
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0283 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1025 0.1488
Plasmodium falciparum protein kinase 7 0.0294 0.6571 0.6542
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0484 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.216 1
Plasmodium vivax hexose transporter 0.0104 0.216 0.2094
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0493 0.8107
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0897 0.1585
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0327 0.0375
Trypanosoma brucei glucose transporter, putative 0.0032 0.0493 0.8107
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0484 0.0404
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0283 0.0201
Echinococcus granulosus solute carrier family 22 0.0015 0.0084 0.0114
Schistosoma mansoni hypothetical protein 0.0016 0.0109 0.0151
Schistosoma mansoni glucose transport protein 0.0104 0.216 0.3143
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0438 0.0631
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0283 0.0308
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0084 0.0062
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.216 0.3143
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0493 0.1973
Loa Loa (eye worm) hypothetical protein 0.0032 0.0484 0.0649
Trypanosoma brucei glucose transporter, putative 0.0032 0.0493 0.8107
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0493 0.8107
Entamoeba histolytica protein kinase, putative 0.0032 0.0484 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0493 0.8107
Schistosoma mansoni protein kinase 0.0032 0.0484 0.0698
Trypanosoma cruzi hexose transporter 0.0032 0.0493 0.8107
Leishmania major glucose transporter, lmgt1 0.0032 0.0493 0.8107
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0104 0.216 0.3143
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0589 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0484 0.0404
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0484 0.0404
Treponema pallidum prolyl-tRNA synthetase 0.0011 0 0.5
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.216 0.3143
Echinococcus granulosus GPCR family 2 0.0016 0.0109 0.0151
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0062
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0235 0.0294
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0235 0.0152
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0484 0.7919
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1025 0.1488
Echinococcus granulosus solute carrier family 22 0.0015 0.0084 0.0114
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0493 0.8107
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0589 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0235 0.3918
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0493 0.1973
Echinococcus multilocularis GPCR, family 2 0.0016 0.0109 0.0151
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0084 0.0114
Loa Loa (eye worm) hypothetical protein 0.0025 0.0327 0.0418
Loa Loa (eye worm) hypothetical protein 0.0023 0.0283 0.0355
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0484 0.0698
Schistosoma mansoni sugar transporter 0.0015 0.0084 0.0114
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0411 0.647
Loa Loa (eye worm) hypothetical protein 0.0031 0.0469 0.0627
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1025 0.1488
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.216 0.3143
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0897 0.1585
Entamoeba histolytica hypothetical protein 0.0023 0.0283 0.1953
Onchocerca volvulus 0.0048 0.0859 1
Leishmania major glucose transporter, lmgt2 0.0032 0.0493 0.8107
Schistosoma mansoni hypothetical protein 0.0048 0.0859 0.1245
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0283 0.0201
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0084 0.0114
Loa Loa (eye worm) hypothetical protein 0.0016 0.0109 0.0098
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0469 0.9399
Echinococcus granulosus solute carrier family 22 0.0015 0.0084 0.0114
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0283 0.3046
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0084 0.2954
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0062
Schistosoma mansoni survival motor neuron protein 0.0048 0.0859 0.1245
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0469 0.0751
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0493 0.8107
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0469 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0062
Schistosoma mansoni sugar transporter 0.0015 0.0084 0.0114
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0484 0.0617
Leishmania major protein kinase, putative 0.0032 0.0484 0.7919
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0469 0.0676
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0493 0.8107
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0283 0.0405
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0484 0.078
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0484 0.0617
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0283 0.5182
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0235 0.2987
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0411 0.0591
Schistosoma mansoni importin beta-1 0.0029 0.0411 0.0591
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0084 0.0114
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0327 0.481
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0062
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0168 0.3649 0.3595
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0484 0.0698
Trypanosoma brucei glucose transporter 2A 0.0032 0.0493 0.8107
Schistosoma mansoni hypothetical protein 0.0034 0.0532 0.0768
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0084 0.0114
Plasmodium vivax importin-beta 2, putative 0.0029 0.0411 0.033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1025 0.1488
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0283 0.395
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0109 0.0049
Trichomonas vaginalis ran, putative 0.0021 0.0235 0.0727
Trypanosoma brucei glucose transporter, putative 0.0032 0.0493 0.8107
Brugia malayi hypothetical protein 0.0025 0.0327 0.0474
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0327 0.0245
Brugia malayi Sugar transporter family protein 0.0104 0.216 0.405
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.5212 0.7594
Entamoeba histolytica hypothetical protein 0.0023 0.0285 0.2003
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.216 0.3143
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0493 0.1973
Echinococcus granulosus snurportin 1 0.0307 0.6861 1
Trypanosoma brucei glucose transporter 1E 0.0032 0.0493 0.8107
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0283 0.0389
Brugia malayi Importin beta-1 subunit 0.0029 0.0411 0.0638
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0217 0.0641
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.216 0.3143
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0109 0.0151
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0469 0.0751
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0327 0.481
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0484 0.0404
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0202 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0285 0.0967
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0493 0.1973
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.6861 1
Schistosoma mansoni protein kinase 0.0032 0.0484 0.0698
Brugia malayi RNA, U transporter 1 0.0082 0.164 0.3035
Plasmodium falciparum importin beta, putative 0.0029 0.0411 0.033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0062
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0235 0.0283
Brugia malayi hypothetical protein 0.0016 0.012 0.0071
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0484 0.0649
Plasmodium falciparum mitogen-activated protein kinase 2 0.0168 0.3649 0.3595
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0411 0.0504
Echinococcus multilocularis snurportin 1 0.0307 0.6861 1
Schistosoma mansoni hypothetical protein 0.0016 0.0109 0.0151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1025 0.1488
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0484 0.0698
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0897 0.1254
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0469 0.0676
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0084 0.0114
Schistosoma mansoni protein kinase 0.0032 0.0484 0.0698
Leishmania major importin beta-1 subunit, putative 0.0023 0.0285 0.3975
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0484 0.0698
Schistosoma mansoni glucose transport protein 0.0104 0.216 0.3143
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0283 0.395
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0109 0.0151
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0327 0.0245
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0589 1
Schistosoma mansoni glucose transport protein 0.0104 0.216 0.3143
Echinococcus multilocularis General substrate transporter 0.009 0.1821 0.2648
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0469 0.0676
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0484 0.0698
Trypanosoma brucei glucose transporter, putative 0.0032 0.0493 0.8107
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0484 0.0617
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0484 0.0404
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0084 0.2954
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0062
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0109 0.0049
Echinococcus granulosus solute carrier family 22 0.0015 0.0084 0.0114
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.5212 0.7594
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.216 0.3143
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0589 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0235 0.0334
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0109 0.0098
Plasmodium falciparum hexose transporter 0.0104 0.216 0.2094
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0154 0.1383
Plasmodium vivax CDK-related protein kinase 6, putative 0.0442 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0285 0.0967
Echinococcus multilocularis solute carrier family 22 0.0015 0.0084 0.0114
Echinococcus multilocularis geminin 0.0169 0.3662 0.5333
Echinococcus multilocularis solute carrier family 22 0.0015 0.0084 0.0114
Schistosoma mansoni glucose transporter 0.0015 0.0084 0.0114
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0283 0.395
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0168 0.3649 0.5495
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0484 0.0698
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0484 0.0698
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0589 0.051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0062
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0283 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0484 0.0698
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0411 0.647
Toxoplasma gondii protein kinase, putative 0.0294 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0062
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0327 0.0245
Leishmania major hypothetical protein, conserved 0.0025 0.0327 0.481
Leishmania major GTP-binding protein, putative 0.0021 0.0235 0.2987
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0084 0.5
Schistosoma mansoni hypothetical protein 0.0016 0.0109 0.0151
Schistosoma mansoni hypothetical protein 0.0104 0.216 0.3143
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0469 0.1855
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0109 0.0151
Toxoplasma gondii facilitative glucose transporter GT1 0.0104 0.216 0.3201
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0235 0.2987
Trypanosoma brucei glucose transporter, putative 0.0032 0.0493 0.8107
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0285 0.3975
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0493 0.1973
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0283 1
Loa Loa (eye worm) sugar transporter 0.0015 0.0084 0.0062
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0283 0.0405
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0493 0.8107
Trypanosoma brucei glucose transporter, putative 0.0032 0.0493 0.8107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0484 0.0698
Entamoeba histolytica protein kinase, putative 0.0032 0.0484 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0109 0.0151
Schistosoma mansoni ran 0.0021 0.0235 0.0334
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0283 0.0961
Echinococcus multilocularis solute carrier family 22 0.0015 0.0084 0.0114
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0484 0.0404
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0484 0.1927
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0493 0.8107
Trypanosoma brucei glucose transporter, putative 0.0032 0.0493 0.8107
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0469 0.0676
Echinococcus multilocularis solute carrier family 22 0.0015 0.0084 0.0114
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0235 0.2987
Leishmania major glucose transporter, lmgt3 0.0032 0.0493 0.8107
Loa Loa (eye worm) hypothetical protein 0.0029 0.0411 0.0541
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0589 0.051
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0285 0.0967
Schistosoma mansoni ran 0.0021 0.0235 0.0334
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0283 0.0405
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1025 0.1836
Loa Loa (eye worm) hypothetical protein 0.005 0.0897 0.1254

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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