TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 456.531 | Formula: C25H32N2O6
H donors: 1 H acceptors: 2 LogP: 3.62 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1cc(ccc1OCC)NC(=O)CN(C(=O)COc1cccc2c1OC(C2)(C)C)C
InChi: 1S/C25H32N2O6/c1-6-30-19-12-11-18(13-21(19)31-7-2)26-22(28)15-27(5)23(29)16-32-20-10-8-9-17-14-25(3,4)33-24(17)20/h8-13H,6-7,14-16H2,1-5H3,(H,26,28)
InChiKey: VQDFIMDIRDSAKS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0333	0.0427
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0493	0.1973
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0165	0.3649	0.3595
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0493	0.8107
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0469	0.9399
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0285	0.0967
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0411	0.0591
Schistosoma mansoni	glucose transporter	0.0014	0.0084	0.0114
Plasmodium falciparum	importin beta, putative	0.0028	0.0411	0.033
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0235	0.0233
Schistosoma mansoni	hypothetical protein	0.0015	0.0109	0.0151
Schistosoma mansoni	ran	0.0021	0.0235	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0484	0.0649
Echinococcus granulosus	solute carrier family 22	0.0014	0.0084	0.0114
Schistosoma mansoni	hypothetical protein	0.0033	0.0532	0.0768
Brugia malayi	Importin beta-1 subunit	0.0028	0.0411	0.0638
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0014	0.0084	0.2954
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0283	0.0389
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1052	0.1526
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0469	0.0751
Schistosoma mansoni	sugar transporter	0.0014	0.0084	0.0114
Entamoeba histolytica	protein kinase, putative	0.0031	0.0484	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0062
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0031	0.0484	0.0404
Brugia malayi	Cam kinase protein 1	0.0031	0.0484	0.078
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.0698
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0283	0.0201
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0469	1
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0469	0.0676
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0469	0.0676
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.1052	0.1887
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.216	0.3143
Entamoeba histolytica	hypothetical protein	0.0023	0.0285	0.2003
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0897	0.1585
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.0698
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0859	0.1512
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0109	0.0151
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0327	0.481
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0285	0.0967
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0062
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0411	0.647
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0031	0.0484	0.0617
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0014	0.0084	0.0114
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0493	0.8107
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0084	0.0114
Schistosoma mansoni	protein kinase	0.0031	0.0484	0.0698
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0285	0.3975
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0859	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0062
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0084	0.0114
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0084	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0283	0.0355
Onchocerca volvulus		0.0047	0.0859	1
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0109	0.0151
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0	0.5
Echinococcus granulosus	GPCR family 2	0.0015	0.0109	0.0151
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0102	0.216	0.3143
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0031	0.0484	0.0404
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0031	0.0484	0.078
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0031	0.0484	0.0698
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0589	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0493	0.8107
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0235	0.0152
Loa Loa (eye worm)	sugar transporter	0.0014	0.0084	0.0062
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1052	0.1526
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0484	0.0698
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0235	0.2987
Trichomonas vaginalis	ran, putative	0.0021	0.0235	0.0727
Mycobacterium ulcerans	integral membrane transport protein	0.0014	0.0084	0.2954
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.8107
Loa Loa (eye worm)	sugar transporter	0.0102	0.216	0.3107
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0493	0.8107
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0493	0.1973
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.216	0.3143
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0109	0.0151
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0438	0.0631
Schistosoma mansoni	sugar transporter	0.0014	0.0084	0.0114
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0283	0.0201
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0031	0.0484	0.0649
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0493	0.1973
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.0698
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0589	0.0779
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.216	0.3143
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0031	0.0484	0.0404
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.0698
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.0698
Plasmodium falciparum	protein kinase 7	0.0288	0.6571	0.6542
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1052	0.1526
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0469	0.0676
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0084	0.0062
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0283	1
Echinococcus granulosus	solute carrier family 22	0.0014	0.0084	0.0114
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.0698
Leishmania major	protein kinase, putative	0.0031	0.0484	0.7919
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0283	0.0308
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0084	0.0114
Schistosoma mansoni	glucose transport protein	0.0102	0.216	0.3143
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.216	0.3143
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0897	0.1585
Brugia malayi	hypothetical protein	0.0025	0.0327	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0469	0.0627
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0589	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0469	0.0676
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0014	0.0084	0.2954
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0327	0.0245
Echinococcus multilocularis	geminin	0.0205	0.4588	0.6684
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0438	0.0631
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0031	0.0484	0.0404
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0084	0.5
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0235	0.0334
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.8107
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0493	0.8107
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0411	0.647
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0109	0.0098
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0327	0.481
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0062
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0484	0.0698
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0532	0.0874
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.8107
Schistosoma mansoni	hypothetical protein	0.0205	0.4588	0.6684
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0235	0.0294
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0217	0.0641
Loa Loa (eye worm)	hypothetical protein	0.0231	0.5212	0.7581
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0301	0.6861	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1052	0.1526
Schistosoma mansoni	hypothetical protein	0.0047	0.0859	0.1245
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1052	0.1526
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0084	0.0114
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1052	0.1526
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0532	0.0719
Schistosoma mansoni	glucose transport protein	0.0102	0.216	0.3143
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.5212	0.7594
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0062
Leishmania major	GTP-binding protein, putative	0.0021	0.0235	0.2987
Echinococcus granulosus	General substrate transporter	0.0088	0.1821	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0062
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0283	0.0405
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0031	0.0484	0.7919
Plasmodium falciparum	hexose transporter	0.0102	0.216	0.2094
Schistosoma mansoni	sugar transporter	0.0014	0.0084	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0062
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0589	0.051
Echinococcus granulosus	geminin	0.0205	0.4588	0.6684
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.0484	0.1927
Leishmania major	glucose transporter, lmgt1	0.0032	0.0493	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0469	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0062
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0285	0.3975
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0235	0.2987
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0031	0.0484	0.0404
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.8107
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0589	1
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0411	0.0591
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0283	0.3046
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0235	0.2987
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0283	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.1052	0.1481
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0897	0.1254
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0031	0.0484	0.0617
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0031	0.0484	0.0649
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0235	0.0283
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0084	0.0114
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0109	0.0151
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.216	0.3143
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0235	0.0152
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0493	0.8107
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0283	0.0405
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0285	0.0967
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0493	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.216	1
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0031	0.0484	0.0404
Trypanosoma cruzi	hexose transporter	0.0032	0.0493	0.8107
Schistosoma mansoni	hypothetical protein	0.0015	0.0109	0.0151
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.395
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0469	0.1855
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.8107
Leishmania major	glucose transporter, lmgt3	0.0032	0.0493	0.8107
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0493	0.1973
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0062
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0589	0.051
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.0961
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0493	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0062
Entamoeba histolytica	hypothetical protein	0.0023	0.0283	0.1953
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0165	0.3649	0.5495
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0327	0.0418
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0327	0.0245
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0235	0.0334
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0084	0.0114
Schistosoma mansoni	hypothetical protein	0.0015	0.0109	0.0151
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0411	0.0504
Toxoplasma gondii	protein kinase, putative	0.0288	0.6571	1
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0084	0.0114
Echinococcus granulosus	solute carrier family 22	0.0014	0.0084	0.0114
Mycobacterium ulcerans	sugar transporter	0.0014	0.0084	0.2954
Brugia malayi	hypothetical protein	0.0016	0.012	0.0071
Echinococcus granulosus	solute carrier family 22	0.0014	0.0084	0.0114
Brugia malayi	hypothetical protein	0.0231	0.5212	1
Entamoeba histolytica	protein kinase, putative	0.0031	0.0484	1
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0469	0.0751
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0154	0.1383
Toxoplasma gondii	facilitative glucose transporter GT1	0.0102	0.216	0.3201
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0109	0.0049
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0283	1
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0433	1	1
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0084	0.0114
Schistosoma mansoni	hypothetical protein	0.0205	0.4588	0.6684
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0062
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0235	0.3918
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.216	0.3143
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0589	1
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.395
Schistosoma mansoni	hypothetical protein	0.0015	0.0109	0.0151
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0327	0.0375
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0493	0.1973
Schistosoma mansoni	hypothetical protein	0.0102	0.216	0.3143
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0031	0.0484	0.0404
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0031	0.0484	0.0617
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.216	0.3143
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0589	1
Schistosoma mansoni	protein kinase	0.0031	0.0484	0.0698
Echinococcus multilocularis	General substrate transporter	0.0088	0.1821	0.2648
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0165	0.3649	0.3595
Schistosoma mansoni	importin beta-1	0.0028	0.0411	0.0591
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0109	0.0098
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0493	0.1973
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0031	0.0484	0.0404
Schistosoma mansoni	sugar transporter	0.0014	0.0084	0.0114
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0493	0.8107
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.395
Schistosoma mansoni	hypothetical protein	0.0301	0.6861	1
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0493	0.8107
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1052	0.1526
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0897	0.1254
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0109	0.0151
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0283	0.0405
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.8107
Brugia malayi	RNA, U transporter 1	0.008	0.164	0.3035
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0084	0.0062
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0411	0.033
Schistosoma mansoni	ran	0.0021	0.0235	0.0334
Echinococcus multilocularis	snurportin 1	0.0301	0.6861	1
Leishmania major	glucose transporter, lmgt2	0.0032	0.0493	0.8107
Brugia malayi	Sugar transporter family protein	0.0102	0.216	0.405
Echinococcus granulosus	snurportin 1	0.0301	0.6861	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.8107
Schistosoma mansoni	protein kinase	0.0031	0.0484	0.0698
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0283	0.5182
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0327	0.481
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0327	0.0245
Schistosoma mansoni	glucose transport protein	0.0102	0.216	0.3143
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.5212	0.7594
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0283	0.0405
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0031	0.0484	0.0404
Leishmania major	hypothetical protein, conserved	0.0025	0.0327	0.481
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0202	1
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0469	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0411	0.0541
Plasmodium vivax	hexose transporter	0.0102	0.216	0.2094
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0202	1
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0109	0.0049

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	6.5131 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	112.2018 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1890375

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1538355