Detailed information for compound 153851

Basic information

Technical information
  • TDR Targets ID: 153851
  • Name: [2-[3-(diethylamino)-2-hydroxypropoxy]phenyl] -phenylmethanone
  • MW: 327.417 | Formula: C20H25NO3
  • H donors: 1 H acceptors: 2 LogP: 3.39 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CC(COc1ccccc1C(=O)c1ccccc1)O)CC
  • InChi: 1S/C20H25NO3/c1-3-21(4-2)14-17(22)15-24-19-13-9-8-12-18(19)20(23)16-10-6-5-7-11-16/h5-13,17,22H,3-4,14-15H2,1-2H3
  • InChiKey: GMNUWTLMPFWNMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-[3-(diethylamino)-2-hydroxy-propoxy]phenyl]-phenyl-methanone
  • [2-(3-diethylamino-2-hydroxypropoxy)phenyl]-phenylmethanone
  • [2-(3-diethylamino-2-hydroxy-propoxy)phenyl]-phenyl-methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0185 0.1897 0.1897
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0117 0.1115 0.2516
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0068 0.0547 0.0547
Brugia malayi hypothetical protein 0.0023 0.0028 0.0035
Onchocerca volvulus 0.0068 0.0547 0.1235
Loa Loa (eye worm) hypothetical protein 0.0043 0.0262 0.0262
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0262 0.0325
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0028
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0028 0.0028
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0262 0.0262
Brugia malayi steroid hormone receptor 0.0043 0.0262 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0262 0.0325
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0068 0.0547 0.0547
Echinococcus granulosus metabotropic glutamate receptor 2 0.0603 0.673 0.673
Loa Loa (eye worm) hypothetical protein 0.0043 0.0262 0.0262
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0262 0.0285
Onchocerca volvulus 0.0043 0.0262 0.0592
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.0262 0.0262
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0068 0.0547 0.0547
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.0262 0.0285
Loa Loa (eye worm) hypothetical protein 0.0068 0.0547 0.0547
Echinococcus multilocularis glutamate receptor 2 0.0068 0.0547 0.0547
Brugia malayi solute carrier family 40, member 1 0.0404 0.4432 0.5486
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0262 0.0262
Loa Loa (eye worm) RGC/RGC protein kinase 0.0068 0.0547 0.0547
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0028 0.003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.0262 0.0262
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0117 0.1115 0.138
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0603 0.673 0.673
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0262 0.0262
Onchocerca volvulus 0.0404 0.4432 1
Loa Loa (eye worm) norepinephrine transporter 0.0102 0.0947 0.0947
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.0262 0.0592
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0262 0.0285
Echinococcus multilocularis nmda type glutamate receptor 0.0068 0.0547 0.0547
Loa Loa (eye worm) hypothetical protein 0.0043 0.0262 0.0262
Brugia malayi nuclear receptor NHR-88 0.0043 0.0262 0.0325
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0262 0.0285
Loa Loa (eye worm) RGC/RGC protein kinase 0.0068 0.0547 0.0547
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0262 0.0325
Brugia malayi hypothetical protein 0.0068 0.0547 0.0678
Schistosoma mansoni hypothetical protein 0.0117 0.1115 0.121
Loa Loa (eye worm) hypothetical protein 0.0043 0.0262 0.0262
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0068 0.0547 0.0547
Onchocerca volvulus 0.0102 0.0947 0.2136
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.0262 0.0592
Echinococcus granulosus GPCR family 3 C terminal 0.0117 0.1115 0.1115
Onchocerca volvulus Poor gastrulation protein homolog 0.0117 0.1115 0.2516
Loa Loa (eye worm) hypothetical protein 0.0068 0.0547 0.0547
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.0262 0.0262
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0185 0.1897 0.1897
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0262 0.0285
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0068 0.0547 0.1235
Schistosoma mansoni tyrosine kinase 0.0068 0.0547 0.0594
Echinococcus granulosus glutamate receptor 2 0.0068 0.0547 0.0547
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0028 0.0028
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0028
Echinococcus multilocularis GPCR, family 3, C terminal 0.0117 0.1115 0.1115
Loa Loa (eye worm) hypothetical protein 0.0068 0.0547 0.0547
Loa Loa (eye worm) hypothetical protein 0.0887 1 1
Schistosoma mansoni coup transcription factor 0.0043 0.0262 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0262 0.0325
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0262 0.0325
Entamoeba histolytica hypothetical protein 0.0068 0.0547 0.5
Brugia malayi Metabotropic glutamate receptor precursor. 0.072 0.8079 1
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0262 0.0325
Echinococcus granulosus glutamate receptor 2 0.0068 0.0547 0.0547
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0653 0.7297 0.9032
Brugia malayi nuclear hormone receptor 0.0043 0.0262 0.0325
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.0262 0.0262
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0028 0.0035
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0262 0.0325
Loa Loa (eye worm) hypothetical protein 0.0068 0.0547 0.0547
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0262 0.0285
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0028
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.0262 0.0262
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0262 0.0262
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0262 0.0262
Echinococcus multilocularis glutamate receptor 2 0.0068 0.0547 0.0547
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0262 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0262 0.0325
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0262 0.0262
Echinococcus granulosus FTZ F1 alpha 0.0043 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0185 0.1897 0.1897
Loa Loa (eye worm) hypothetical protein 0.0102 0.0947 0.0947
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0068 0.0547 0.0547
Trypanosoma cruzi extracellular receptor, putative 0.0068 0.0547 0.5
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0068 0.0547 0.0547
Schistosoma mansoni protein kinase 0.0068 0.0547 0.0594
Treponema pallidum sodium- and chloride- dependent transporter 0.0102 0.0947 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0262 0.0285
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0262 0.0262
Brugia malayi hypothetical protein 0.0023 0.0028 0.0035
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0819 0.9218 1
Onchocerca volvulus 0.0068 0.0547 0.1235
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0262 0.0285
Brugia malayi Receptor family ligand binding region containing protein 0.0185 0.1897 0.2348
Loa Loa (eye worm) hypothetical protein 0.0404 0.4432 0.4432
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0262 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0262 0.0325
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0068 0.0547 0.0547
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0028 0.0035
Loa Loa (eye worm) hypothetical protein 0.0043 0.0262 0.0262
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0262 0.0262
Echinococcus granulosus tyrosine kinase 0.0068 0.0547 0.0547
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0262 0.0262
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0887 1 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0102 0.0947 0.1027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0262 0.0262
Echinococcus granulosus nmda type glutamate receptor 0.0068 0.0547 0.0547
Echinococcus granulosus serotonin transporter 0.0102 0.0947 0.0947
Schistosoma mansoni sodium/chloride dependent transporter 0.0102 0.0947 0.1027
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0262 0.0325
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0043 0.0262 0.0262
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0262 0.0262
Echinococcus multilocularis serotonin transporter 0.0102 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.0043 0.0262 0.0262
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0068 0.0547 0.0547
Loa Loa (eye worm) glutamate receptor 0.0283 0.3036 0.3036
Loa Loa (eye worm) hypothetical protein 0.0068 0.0547 0.0547
Brugia malayi Guanylyl cyclase protein 23 0.0068 0.0547 0.0678
Loa Loa (eye worm) RGC/RGC protein kinase 0.0068 0.0547 0.0547
Loa Loa (eye worm) serotonin transporter b 0.0102 0.0947 0.0947
Loa Loa (eye worm) solute carrier family 6 member 4 0.0102 0.0947 0.0947
Schistosoma mansoni tyrosine kinase 0.0068 0.0547 0.0594
Brugia malayi Receptor family ligand binding region containing protein 0.0068 0.0547 0.0678
Loa Loa (eye worm) hypothetical protein 0.0102 0.0947 0.0947
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0043 0.0262 0.0262
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.0262 0.0592
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0262 0.0325
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0068 0.0547 0.0547
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0028
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0262 0.0285
Brugia malayi metabotropic glutamate receptor type 2 0.0351 0.3818 0.4726
Echinococcus multilocularis tyrosine kinase 0.0068 0.0547 0.0547
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0262 0.0262
Echinococcus multilocularis receptor type guanylyl cyclase 0.0068 0.0547 0.0547
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0068 0.0547 0.0547
Loa Loa (eye worm) glutamate receptor 0.072 0.8079 0.8079
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0262 0.0325
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0262 0.0262
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0028 0.0028
Brugia malayi ecdysteroid receptor 0.0043 0.0262 0.0325
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0068 0.0547 0.0678
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0262 0.0325
Loa Loa (eye worm) hypothetical protein 0.0102 0.0947 0.0947
Echinococcus granulosus atrial natriuretic peptide receptor 0.0068 0.0547 0.0547
Brugia malayi nuclear receptor RXR 0.0023 0.0028 0.0035
Schistosoma mansoni metabotropic glutamate receptor 0.0603 0.673 0.73
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0262 0.0262
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0117 0.1115 0.1115
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0028 0.003
Schistosoma mansoni glutamate receptor NMDA 0.0068 0.0547 0.0594
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0262 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0262 0.0325
Loa Loa (eye worm) hypothetical protein 0.0023 0.0028 0.0028
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0102 0.0947 0.1172
Loa Loa (eye worm) hypothetical protein 0.0068 0.0547 0.0547
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0068 0.0547 0.0547
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0262 0.0325
Echinococcus granulosus receptor type guanylyl cyclase 0.0068 0.0547 0.0547
Leishmania major extracellular receptor, putative 0.0068 0.0547 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0262 0.0285
Schistosoma mansoni metabotropic glutamate receptor 0.0351 0.3818 0.4141

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 2.322 uM Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay ChEMBL. 17352460
EC50 (binding) = 2.322 uM Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay ChEMBL. 17352460
ED50 (functional) = 150 nM The chemosensitizing effect of the compound was measured against P-glycoprotein expressing CCRF-CEM cells in the presence of 5 microM daunomycin ChEMBL. 7629817
ED50 (functional) = 150 nM The chemosensitizing effect of the compound was measured against P-glycoprotein expressing CCRF-CEM cells in the presence of 5 microM daunomycin ChEMBL. 7629817
RP (functional) = 9 The reversion potency of compound was measured against P-glycoprotein expressing CCRF-CEM cells and expressed as the ratio of ED50 of the compound in the absence and presence of daunomycin ChEMBL. 7629817

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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