Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0025 | 0.0503 | 0.5 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0025 | 0.0503 | 0.5 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0066 | 0.3784 | 0.5 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0066 | 0.3784 | 0.5 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0066 | 0.3784 | 0.5 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0066 | 0.3784 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0066 | 0.3784 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0503 | 0.0503 |
Brugia malayi | protein ZK524.3 | 0.0025 | 0.0503 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1767 | 0.1767 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1767 | 0.4669 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0025 | 0.0503 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3289 | 0.3289 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0025 | 0.0503 | 0.5 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0025 | 0.0503 | 0.133 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3289 | 0.3289 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0025 | 0.0503 | 0.133 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0066 | 0.3784 | 1 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0025 | 0.0503 | 0.133 |
Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 0.3784 |
Onchocerca volvulus | 0.0041 | 0.1758 | 0.5 | |
Plasmodium falciparum | methionine--tRNA ligase | 0.0066 | 0.3784 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0503 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0503 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3289 | 0.3289 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0025 | 0.0503 | 0.5 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0025 | 0.0503 | 0.133 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0025 | 0.0503 | 0.133 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0066 | 0.3784 | 0.5 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0066 | 0.3784 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1767 | 0.1767 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0066 | 0.3784 | 1 |
Brugia malayi | methionyl-tRNA synthetase | 0.0025 | 0.0503 | 0.0503 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0041 | 0.1758 | 0.1758 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 0.3784 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 5.602 uM | PubChem BioAssay. Luminescence-based biochemical high throughput dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 14.202 uM | PubChem BioAssay. Counterscreen Fluorescent Polarization-based biochemical high throughput orthogonal dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.