Detailed information for compound 1541036

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 463.598 | Formula: C24H29N7OS
  • H donors: 1 H acceptors: 5 LogP: 3.72 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCCC(c1nnnn1Cc1ccccc1)N1CCC(CC1)n1c(O)nc2c1cccc2
  • InChi: 1S/C24H29N7OS/c1-33-16-13-22(23-26-27-28-30(23)17-18-7-3-2-4-8-18)29-14-11-19(12-15-29)31-21-10-6-5-9-20(21)25-24(31)32/h2-10,19,22H,11-17H2,1H3,(H,25,32)
  • InChiKey: KDYCPGMUHGUAKJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens paired box 8 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_139945 All targets in OG5_139945
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.003 0.0202 0.0202
Loa Loa (eye worm) RNA binding protein 0.0076 0.1021 0.1021
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0328 0.0998
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0731 0.0731
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0202 1
Schistosoma mansoni hypothetical protein 0.0036 0.0305 0.0927
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0328 0.0796
Brugia malayi bHLH-PAS transcription factor 0.0045 0.0453 0.0453
Brugia malayi PAS domain containing protein 0.006 0.0731 0.0731
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0328 0.0796
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0328 0.0328
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0202 1
Brugia malayi nuclear receptor NHR-88 0.0038 0.0328 0.0328
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0328 0.0328
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0328 0.0328
Echinococcus granulosus tar DNA binding protein 0.0076 0.1021 0.2478
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0328 0.0328
Brugia malayi hypothetical protein 0.0036 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0038 0.0328 0.0328
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1021 0.3109
Echinococcus granulosus single minded 2 0.0045 0.0453 0.1099
Loa Loa (eye worm) hypothetical protein 0.0041 0.0393 0.0393
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1021 0.3109
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0305 0.0739
Brugia malayi nuclear receptor RXR 0.002 0.0013 0.0013
Echinococcus granulosus aryl hydrocarbon receptor 0.013 0.1973 0.4788
Schistosoma mansoni aryl hydrocarbon receptor 0.0175 0.2766 0.8418
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0328 0.0328
Echinococcus multilocularis aryl hydrocarbon receptor 0.013 0.1973 0.4788
Loa Loa (eye worm) hypothetical protein 0.0038 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0013
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1021 0.1021
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0328 0.0328
Entamoeba histolytica hypothetical protein 0.0036 0.0305 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0328 0.0328
Echinococcus multilocularis thyroid hormone receptor alpha 0.0038 0.0328 0.0796
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0328 0.0998
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2225 0.2225
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0305 0.0739
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0202 1
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0013 0.0013
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0013 0.0032
Leishmania major hypothetical protein, conserved 0.003 0.0202 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0202 0.0202
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0251 0.4121 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0731 0.0731
Loa Loa (eye worm) hypothetical protein 0.0244 0.3999 0.3999
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0013 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0328 0.0328
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0328 0.0796
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0328 0.0998
Loa Loa (eye worm) hypothetical protein 0.0038 0.0328 0.0328
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0328 0.0328
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0204 0.3285 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1964 0.1964
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0202 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0038 0.0328 0.0328
Brugia malayi hypothetical protein 0.002 0.0013 0.0013
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0251 0.4121 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0202 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0328 0.0328
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0114 0.1686 0.1686
Onchocerca volvulus 0.0197 0.3163 0.6297
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0328 0.0998
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0328 0.0796
Brugia malayi nuclear hormone receptor 0.0038 0.0328 0.0328
Onchocerca volvulus 0.0291 0.483 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0328 0.0998
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0328 0.0328
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1021 0.3109
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0328 0.0328
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0328 0.0328
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0393 0.0393
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0328 0.0998
Echinococcus multilocularis geminin 0.0168 0.2644 0.6416
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0328 0.0328
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0328 0.0328
Brugia malayi MH2 domain containing protein 0.0144 0.2225 0.2225
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0328 0.0328
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1021 0.1021
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0013 0.004
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0328 0.0998
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0328 0.0796
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0328 0.0796
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0013
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0202 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0328 0.0328
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0114 0.1695 0.1695
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0328 0.0998
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0328 0.0328
Brugia malayi hypothetical protein 0.0197 0.3163 0.3163
Brugia malayi TAR-binding protein 0.0076 0.1021 0.1021
Loa Loa (eye worm) hypothetical protein 0.006 0.0731 0.0731
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1021 0.2478
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0328 0.0328
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0328 0.0328
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0328 0.0796
Entamoeba histolytica hypothetical protein 0.0036 0.0305 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2225 0.2225
Echinococcus granulosus jun protein 0.0251 0.4121 1
Schistosoma mansoni single-minded 0.006 0.0731 0.2226
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0038 0.0328 0.0328
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0328 0.0796
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1021 0.3109
Schistosoma mansoni coup transcription factor 0.0038 0.0328 0.0998
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0013
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0328 0.0796
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0328 0.0796
Brugia malayi hypothetical protein 0.002 0.0013 0.0013
Brugia malayi hypothetical protein 0.002 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0328 0.0328
Brugia malayi steroid hormone receptor 0.0038 0.0328 0.0328
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0328 0.0998
Brugia malayi ecdysteroid receptor 0.0038 0.0328 0.0328
Schistosoma mansoni hypothetical protein 0.0168 0.2644 0.8048
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0328 0.0998
Entamoeba histolytica hypothetical protein 0.0036 0.0305 0.5
Loa Loa (eye worm) hypothetical protein 0.0581 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0013 0.0032
Entamoeba histolytica hypothetical protein 0.0036 0.0305 0.5
Loa Loa (eye worm) hypothetical protein 0.0114 0.1686 0.1686
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0328 0.0998
Mycobacterium ulcerans putative regulatory protein 0.0045 0.0453 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0328 0.0796
Brugia malayi RNA binding protein 0.0076 0.1021 0.1021
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0328 0.0796
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0731 0.0731
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0328 0.0796
Loa Loa (eye worm) hypothetical protein 0.0038 0.0328 0.0328
Schistosoma mansoni hypothetical protein 0.0041 0.0393 0.1195
Echinococcus granulosus geminin 0.0168 0.2644 0.6416
Loa Loa (eye worm) pax transcription factor protein 2 0.0291 0.483 0.483
Loa Loa (eye worm) hypothetical protein 0.0038 0.0328 0.0328
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0328 0.0328
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0202 1
Echinococcus multilocularis transfer RNA-Lys 0.0045 0.0453 0.1099
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0328 0.0998
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0328 0.0328
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1021 0.1021
Onchocerca volvulus 0.0129 0.1964 0.3633
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1021 0.3109
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0328 0.0328
Onchocerca volvulus 0.0045 0.0462 0.0298
Schistosoma mansoni jun-related protein 0.0204 0.3285 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0328 0.0796
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0305 0.0927
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0328 0.0796
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0328 0.0796
Brugia malayi Pax transcription factor protein 2 0.0291 0.483 0.483
Brugia malayi bZIP transcription factor family protein 0.0251 0.4121 0.4121
Echinococcus multilocularis jun protein 0.0251 0.4121 1
Schistosoma mansoni hypothetical protein 0.0168 0.2644 0.8048
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0328 0.0796

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 0.538 uM PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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