Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 0.6288 | 0.6096 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.6482 | 0.63 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.6482 | 0.63 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.6482 | 0.63 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.1197 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.7303 | 0.7163 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.1197 | 0.0741 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.1197 | 0.1904 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1197 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1197 | 0.1904 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.1197 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.6482 | 0.63 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.6482 | 0.63 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.6482 | 0.63 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1197 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1197 | 0.1904 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1197 | 0.1904 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.1197 | 0.0741 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.7303 | 0.7163 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1197 | 0.1904 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0054 | 0.6288 | 0.6096 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.7303 | 0.7163 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.4151 | 0.3848 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.4151 | 0.3848 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1197 | 0.1904 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.1197 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.6482 | 0.63 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1197 | 0.1904 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.3628 | 0.4775 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.1197 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1197 | 0.1904 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.1197 | 0.0741 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1197 | 0.1904 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.7303 | 0.7163 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1197 | 0.1904 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.1197 | 0.0741 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.1197 | 0.0741 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1197 | 0.1904 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.6482 | 0.63 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.3628 | 0.4775 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.1197 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 0.6288 | 0.6096 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.6288 | 0.6096 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.1197 | 0.0741 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.3628 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 0.6288 | 0.6096 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1197 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4151 | 0.3848 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 0.6288 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1197 | 0.1904 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.1197 | 0.0741 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.1197 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1197 | 0.1904 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 0.6288 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.1197 | 0.0741 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 0.6288 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.6482 | 0.63 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 42.5615 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.