Detailed information for compound 154995

Basic information

Technical information
  • TDR Targets ID: 154995
  • Name: tert-butyl N-[(2S)-1-oxo-3-phenylpropan-2-yl] carbamate
  • MW: 249.306 | Formula: C14H19NO3
  • H donors: 1 H acceptors: 2 LogP: 2.45 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C
  • InChi: 1S/C14H19NO3/c1-14(2,3)18-13(17)15-12(10-16)9-11-7-5-4-6-8-11/h4-8,10,12H,9H2,1-3H3,(H,15,17)/t12-/m0/s1
  • InChiKey: ZJTYRNPLVNMVPQ-LBPRGKRZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • tert-butyl N-[(1S)-1-benzyl-2-oxo-ethyl]carbamate
  • N-[(1S)-1-benzyl-2-oxoethyl]carbamic acid tert-butyl ester
  • tert-butyl N-[(2S)-1-oxo-3-phenyl-propan-2-yl]carbamate
  • N-[(1S)-1-benzyl-2-keto-ethyl]carbamic acid tert-butyl ester
  • tert-butyl N-[(1S)-1-formyl-2-phenyl-ethyl]carbamate
  • N-[(1S)-1-formyl-2-phenylethyl]carbamic acid tert-butyl ester
  • N-[(1S)-1-(benzyl)-2-keto-ethyl]carbamic acid tert-butyl ester
  • 72155-45-4
  • N-Boc-L-phenylalaninal
  • ZINC01886491
  • (S)-(−)-2-(tert-Butoxycarbonylamino)-3-phenylpropanal
  • 469297_ALDRICH

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin K Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.059 1
Plasmodium vivax vivapain-1 0.0014 0.0163 0.1389
Plasmodium vivax ornithine aminotransferase, putative 0.0045 0.1172 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.059 1
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0045 0.1172 0.6
Echinococcus multilocularis cysteine protease 0.0027 0.059 0.504
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.059 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0747 0.6377
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.059 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.059 0.0435
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.059 0.504
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.059 0.0435
Echinococcus granulosus cysteine protease 0.0014 0.0163 0.1389
Echinococcus multilocularis ornithine aminotransferase 0.0045 0.1172 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.059 0.0435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.059 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.059 0.0435
Trypanosoma cruzi cysteine proteinase, putative 0.0014 0.0163 0.2757
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.059 0.0435
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.059 0.3024
Plasmodium vivax unspecified product 0.0014 0.0163 0.1389
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.059 1
Echinococcus granulosus Aminotransferase class III 0.0045 0.1172 1
Echinococcus granulosus cathepsin l1 0.0027 0.059 0.504
Schistosoma mansoni hypothetical protein 0.0032 0.0747 0.3826
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.059 0.504
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.059 0.504
Loa Loa (eye worm) hypothetical protein 0.0032 0.0747 0.1326
Onchocerca volvulus Cathepsin L homolog 0.0027 0.059 0.1048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0299 0.0138
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0027 0.059 0.1048
Loa Loa (eye worm) hypothetical protein 0.01 0.2991 0.5308
Toxoplasma gondii cathepsin CPL 0.0027 0.059 0.504
Plasmodium vivax vivapain-2 0.0027 0.059 0.504
Loa Loa (eye worm) hypothetical protein 0.0181 0.5636 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0299 0.0138
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.1952 0.3465
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.059 0.0435
Leishmania major cathepsin L-like protease 0.0027 0.059 0.5
Leishmania major cysteine peptidase A (CPA) 0.0027 0.059 0.5
Brugia malayi cathepsin L-like precursor 0.0018 0.0299 0.053
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.059 0.3024
Leishmania major cathepsin L-like protease 0.0027 0.059 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.059 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.059 0.1048
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.2991 0.5308
Schistosoma mansoni dishevelled 0.0009 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0299 0.053
Brugia malayi Cathepsin L-like precursor 0.0018 0.0299 0.053
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0014 0.0163 0.0834
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.059 0.0435
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0747 0.1326
Leishmania major cathepsin L-like protease 0.0027 0.059 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.059 0.0435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.059 0.0435
Loa Loa (eye worm) hypothetical protein 0.0018 0.0299 0.053
Brugia malayi Cathepsin L-like precursor 0.0027 0.059 0.1048
Leishmania major cathepsin L-like protease 0.0027 0.059 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.059 1
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.059 1
Loa Loa (eye worm) ctsf protein 0.0027 0.059 0.1048
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.059 0.504
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0045 0.1172 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0747 0.1326
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.059 1
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0299 0.3182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.059 0.0435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.059 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.059 0.0435
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0045 0.1172 0.5
Loa Loa (eye worm) fibroinase 0.0027 0.059 0.1048
Plasmodium falciparum cysteine proteinase falcipain 3 0.0027 0.059 0.424
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0299 0.1531
Schistosoma mansoni hypothetical protein 0.0032 0.0747 0.3826
Brugia malayi Cathepsin L-like precursor 0.0027 0.059 0.1048
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 0.059 0.504
Brugia malayi Cathepsin L-like precursor 0.0027 0.059 0.1048
Onchocerca volvulus 0.0027 0.059 0.1048
Echinococcus multilocularis ornithine aminotransferase 0.0045 0.1172 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.059 0.0435
Leishmania major cathepsin L-like protease 0.0027 0.059 0.5
Echinococcus multilocularis Aminotransferase class III 0.0045 0.1172 1
Schistosoma mansoni dep domain containing protein 0.0009 0 0.0001
Trypanosoma cruzi cysteine proteinase, putative 0.0014 0.0163 0.2757
Brugia malayi Cathepsin L-like precursor 0.0027 0.059 0.1048
Schistosoma mansoni z-protein (S1r protein) 0.0009 0 0.0001
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0018 0.0299 0.5061
Leishmania major cathepsin L-like protease 0.0027 0.059 0.5
Loa Loa (eye worm) cysteine protease 0.0027 0.059 0.1048
Onchocerca volvulus Cathepsin F homolog 0.0027 0.059 0.1048
Mycobacterium ulcerans hypothetical protein 0.0315 1 1
Onchocerca volvulus 0.0027 0.059 0.1048
Brugia malayi Cathepsin L-like precursor 0.0018 0.0299 0.053
Onchocerca volvulus 0.0027 0.059 0.1048
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0747 0.6377
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.059 0.0435
Onchocerca volvulus 0.0027 0.059 0.1048
Echinococcus multilocularis cysteine protease 0.0027 0.059 0.504
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0315 1 1
Brugia malayi N-terminal motif family protein 0.0181 0.5636 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0018 0.0299 0.053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.059 0.0435
Leishmania major cathepsin L-like protease 0.0027 0.059 0.5
Mycobacterium tuberculosis Probable aminotransferase 0.0315 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0014 0.0163 0.0289
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.059 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.059 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.1952 0.3465
Onchocerca volvulus 0.0027 0.059 0.1048
Echinococcus granulosus cathepsin l1 0.0018 0.0299 0.255
Loa Loa (eye worm) hypothetical protein 0.0027 0.059 0.1048
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.059 1
Trypanosoma cruzi cysteine peptidase, putative 0.0014 0.0163 0.2757
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.059 0.1048
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 0.059 0.504
Echinococcus multilocularis GPCR, family 2 0.0032 0.0747 0.6377
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0747 0.6377
Trypanosoma cruzi cysteine protease, putative 0.0014 0.0163 0.2757
Onchocerca volvulus 0.0027 0.059 0.1048
Brugia malayi Papain family cysteine protease containing protein 0.0014 0.0163 0.0289
Schistosoma mansoni hypothetical protein 0.0069 0.1952 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.059 0.0435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.059 0.0435
Schistosoma mansoni hypothetical protein 0.0032 0.0747 0.3826
Plasmodium falciparum ornithine aminotransferase 0.0045 0.1172 1
Schistosoma mansoni hypothetical protein 0.0032 0.0747 0.3826
Echinococcus multilocularis cathepsin L 0.0014 0.0163 0.1389
Onchocerca volvulus 0.0018 0.0299 0.053
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0315 1 1
Schistosoma mansoni regulator of G protein signaling 0.0009 0 0.0001
Plasmodium vivax vivapain-3 0.0014 0.0163 0.1389
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.059 0.0435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.059 1
Echinococcus granulosus cathepsin L cysteine protease 0.0014 0.0163 0.1389
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.059 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0027 0.059 0.424
Echinococcus granulosus cathepsin L 0.0014 0.0163 0.1389
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0027 0.059 0.424
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0045 0.1172 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.059 0.0435
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.059 0.0435
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.059 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.2991 0.5308
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0045 0.1172 0.2079
Schistosoma mansoni dishevelled 0.0009 0 0.0001
Leishmania major cathepsin L-like protease 0.0027 0.059 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.2991 0.5308
Echinococcus granulosus GPCR family 2 0.0032 0.0747 0.6377
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0014 0.0163 0.2757
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.059 0.0435
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.5636 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0014 0.0163 0.0834
Loa Loa (eye worm) hypothetical protein 0.0018 0.0299 0.053
Brugia malayi Cathepsin L-like precursor 0.0027 0.059 0.1048
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0315 1 1
Onchocerca volvulus 0.0027 0.059 0.1048
Onchocerca volvulus Cathepsin L homolog 0.0027 0.059 0.1048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.059 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.059 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.059 0.0435
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.059 0.0435
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0014 0.0163 0.0834
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.059 0.0435
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0747 0.6377
Echinococcus granulosus ornithine aminotransferase 0.0045 0.1172 1
Plasmodium vivax vivapain-2 0.0027 0.059 0.504
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.059 0.0435
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0747 0.1326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.059 0.0435
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.059 0.1048

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 110 nM Inhibiory activity against recombinant human cathepsin K ChEMBL. 14684342
IC50 (binding) = 110 nM Inhibiory activity against recombinant human cathepsin K ChEMBL. 14684342

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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