Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0101 | 0.0144 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0513 | 0.0791 | 0.5064 |
Echinococcus granulosus | guanine nucleotide binding protein subunit | 0.0022 | 0.002 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0059 | 0.0322 |
Onchocerca volvulus | 0.0998 | 0.1553 | 1 | |
Onchocerca volvulus | 0.0998 | 0.1553 | 1 | |
Schistosoma mansoni | GTP-binding protein (I) alpha-1subunit gnai1 | 0.0022 | 0.002 | 0.0128 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0059 | 0.0322 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0513 | 0.0791 | 0.5095 |
Brugia malayi | Guanine nucleotide-binding protein alpha-3 subunit, putative | 0.0022 | 0.002 | 0.0066 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0998 | 0.1553 | 0.1545 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0095 | 0.0135 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein G protein | 0.0022 | 0.002 | 0.0066 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.0059 | 0.0322 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0101 | 0.0144 | 0.0534 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0101 | 0.0144 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein subunit | 0.0022 | 0.002 | 0.0066 |
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0022 | 0.002 | 0.0128 |
Schistosoma mansoni | GTP-binding protein alpha subunit | 0.0022 | 0.002 | 0.0128 |
Leishmania major | hypothetical protein, conserved | 0.0101 | 0.0144 | 0.0868 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0998 | 0.1553 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0095 | 0.0135 | 0.0752 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0059 | 0.0383 |
Schistosoma mansoni | GTP-binding protein (q) alpha-11 subunit gna11 | 0.0022 | 0.002 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.002 | 0.0066 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0095 | 0.0135 | 0.0813 |
Echinococcus granulosus | guanine nucleotide binding protein G protein | 0.0022 | 0.002 | 0.0066 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0513 | 0.0791 | 0.5095 |
Brugia malayi | hypothetical protein | 0.0065 | 0.0088 | 0.0504 |
Loa Loa (eye worm) | hypothetical protein | 0.0998 | 0.1553 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0998 | 0.1553 | 1 |
Schistosoma mansoni | kinase | 0.0049 | 0.0061 | 0.0396 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0513 | 0.0791 | 0.5064 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0144 | 0.0868 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0513 | 0.0791 | 0.5064 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0095 | 0.0135 | 0.0752 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0998 | 0.1553 | 0.1545 |
Loa Loa (eye worm) | guanine nucleotide-binding protein alpha-6 subunit | 0.0022 | 0.002 | 0.0066 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.0059 | 0.0322 |
Echinococcus granulosus | expressed protein | 0.0022 | 0.002 | 0.0066 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0047 | 0.0059 | 0.0258 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0095 | 0.0135 | 0.0871 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0998 | 0.1553 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0095 | 0.0135 | 0.0813 |
Echinococcus multilocularis | expressed protein | 0.0022 | 0.002 | 0.0066 |
Brugia malayi | beta-lactamase family protein | 0.0998 | 0.1553 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0059 | 0.0383 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0998 | 0.1553 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein subunit | 0.0022 | 0.002 | 0.0066 |
Echinococcus multilocularis | guanine nucleotide binding protein (G protein) | 0.0022 | 0.002 | 0.0066 |
Brugia malayi | Guanine nucleotide-binding protein alpha-12 subunit, putative | 0.0022 | 0.002 | 0.0066 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0059 | 0.0322 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0095 | 0.0135 | 0.0752 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0513 | 0.0791 | 0.5064 |
Schistosoma mansoni | GTP-binding protein (I) alpha-1subunit gnai1 | 0.0022 | 0.002 | 0.0128 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0101 | 0.0144 | 0.0868 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0998 | 0.1553 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.002 | 0.0066 |
Loa Loa (eye worm) | GTP-binding regulatory protein alpha chain | 0.0022 | 0.002 | 0.0066 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.0059 | 0.0322 |
Schistosoma mansoni | trimeric G-protein alpha o subunit | 0.0022 | 0.002 | 0.0128 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0998 | 0.1553 | 0.1545 |
Brugia malayi | G-protein alpha subunit | 0.0022 | 0.002 | 0.0066 |
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0022 | 0.002 | 0.0128 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.0059 | 0.0322 |
Schistosoma mansoni | GTP-binding protein (I) alpha subunit gnai | 0.0022 | 0.002 | 0.0128 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0513 | 0.0791 | 0.5064 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0101 | 0.0144 | 0.0868 |
Brugia malayi | beta-lactamase | 0.0998 | 0.1553 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.0095 | 0.0135 | 0.05 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0998 | 0.1553 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0095 | 0.0135 | 0.0813 |
Echinococcus multilocularis | guanine nucleotide binding protein (G protein) | 0.0022 | 0.002 | 0.0066 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0059 | 0.0322 |
Mycobacterium tuberculosis | Conserved protein | 0.0998 | 0.1553 | 0.1545 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.022 | 0.136 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0095 | 0.0135 | 0.0752 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0095 | 0.0135 | 0.0813 |
Brugia malayi | beta-lactamase family protein | 0.0998 | 0.1553 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0095 | 0.0135 | 0.0813 |
Brugia malayi | guanine nucleotide-binding protein G-o protein alpha subunit | 0.0022 | 0.002 | 0.0066 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0056 | 0.0363 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.3361 | 0.5264 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0998 | 0.1553 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0149 | 0.022 | 0.136 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.1613 | 0.2519 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0998 | 0.1553 | 1 |
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0022 | 0.002 | 0.0128 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0045 | 0.0056 | 0.0302 |
Loa Loa (eye worm) | guanine nucleotide-binding protein alpha-12 subunit | 0.0022 | 0.002 | 0.0066 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0059 | 0.0383 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0998 | 0.1553 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0149 | 0.022 | 0.136 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0047 | 0.0059 | 0.0258 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0998 | 0.1553 | 1 |
Trypanosoma brucei | beta lactamase | 0.1613 | 0.2519 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0998 | 0.1553 | 0.1545 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0095 | 0.0135 | 0.0752 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0095 | 0.0135 | 0.0813 |
Loa Loa (eye worm) | hypothetical protein | 0.0998 | 0.1553 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0998 | 0.1553 | 0.1545 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.1613 | 0.2519 | 0.2512 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0998 | 0.1553 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0182 | 0.0272 | 0.1698 |
Loa Loa (eye worm) | heterotrimeric G protein alpha subunit | 0.0022 | 0.002 | 0.0066 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0095 | 0.0135 | 0.0752 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0998 | 0.1553 | 0.6149 |
Brugia malayi | Guanine nucleotide-binding protein alpha-6 subunit, putative | 0.0022 | 0.002 | 0.0066 |
Brugia malayi | hypothetical protein | 0.0101 | 0.0144 | 0.0868 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0513 | 0.0791 | 0.5064 |
Loa Loa (eye worm) | hypothetical protein | 0.0998 | 0.1553 | 1 |
Brugia malayi | guanine nucleotide-binding protein G(o), alpha subunit, putative | 0.0022 | 0.002 | 0.0066 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0095 | 0.0135 | 0.0813 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.001 | 0.0063 |
Plasmodium vivax | hypothetical protein, conserved | 0.0998 | 0.1553 | 1 |
Schistosoma mansoni | GTP-binding protein alpha subunit | 0.0022 | 0.002 | 0.0128 |
Leishmania major | hypothetical protein, conserved | 0.0998 | 0.1553 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0998 | 0.1553 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0095 | 0.0135 | 0.0752 |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | 0.0022 | 0.002 | 0.0128 |
Brugia malayi | guanine nucleotide-binding protein alpha-3 subunit, putative | 0.0022 | 0.002 | 0.0066 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0513 | 0.0791 | 0.5095 |
Loa Loa (eye worm) | hypothetical protein | 0.0998 | 0.1553 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.002 | 0.0066 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0045 | 0.0056 | 0.0302 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.002 | 0.0066 |
Echinococcus granulosus | gtp binding protein I alpha 1subunit | 0.0022 | 0.002 | 0.0066 |
Echinococcus multilocularis | gtp binding protein (I) alpha 1subunit | 0.0022 | 0.002 | 0.0066 |
Schistosoma mansoni | GTP-binding protein (q) alpha-11 subunit gna11 | 0.0022 | 0.002 | 0.0128 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.1613 | 0.2519 | 0.2604 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.0175 | 0.1069 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0149 | 0.022 | 0.136 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0182 | 0.0272 | 0.1643 |
Brugia malayi | Guanine nucleotide-binding protein alpha-3 subunit, putative | 0.0022 | 0.002 | 0.0066 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.0175 | 0.1069 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0102 | 0.0145 | 0.0879 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0998 | 0.1553 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0998 | 0.1553 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.002 | 0.0066 |
Toxoplasma gondii | ABC1 family protein | 0.0998 | 0.1553 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0998 | 0.1553 | 0.1545 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.0175 | 0.1069 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0145 | 0.0879 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0998 | 0.1553 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0998 | 0.1553 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein subunit | 0.0022 | 0.002 | 0.0066 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0998 | 0.1553 | 0.1545 |
Loa Loa (eye worm) | hypothetical protein | 0.0998 | 0.1553 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0272 | 0.1698 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.3361 | 0.5264 | 0.5259 |
Brugia malayi | GTP-binding regulatory protein alpha chain - starfish, putative | 0.0022 | 0.002 | 0.0066 |
Onchocerca volvulus | 0.0998 | 0.1553 | 1 | |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.0059 | 0.0322 |
Giardia lamblia | Kinase, PLK | 0.0095 | 0.0135 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0059 | 0.0383 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0095 | 0.0135 | 0.0752 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0101 | 0.0144 | 0.0868 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0998 | 0.1553 | 0.1545 |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | 0.0022 | 0.002 | 0.0128 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.0145 | 0.0937 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0101 | 0.0144 | 0.0868 |
Loa Loa (eye worm) | G protein alpha subunit 3 | 0.0022 | 0.002 | 0.0066 |
Brugia malayi | guanine nucleotide-binding protein alpha-7 subunit, putative | 0.0022 | 0.002 | 0.0066 |
Mycobacterium tuberculosis | Conserved protein | 0.0998 | 0.1553 | 0.1545 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0059 | 0.0322 |
Brugia malayi | hypothetical protein | 0.0022 | 0.002 | 0.0066 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 9.5 mg kg-1 | Ability to block the LTD4 pressor response in pithed rats after intravenous administration | ChEMBL. | 1654427 |
ED50 (functional) | = 9.5 mg kg-1 | Ability to block the LTD4 pressor response in pithed rats after intravenous administration | ChEMBL. | 1654427 |
pKB (functional) | = 6.81 | In vitro ability to antagonize LTD4-induced contractions of guinea pig ileum. | ChEMBL. | 1654427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.