Detailed information for compound 1553335

Basic information

Technical information
  • TDR Targets ID: 1553335
  • Name: 2-[(4-amino-1,2,4-triazol-3-yl)sulfanyl]-N-(5 -methyl-1,2-oxazol-3-yl)acetamide
  • MW: 254.269 | Formula: C8H10N6O2S
  • H donors: 2 H acceptors: 4 LogP: 0.11 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(no1)NC(=O)CSc1nncn1N
  • InChi: 1S/C8H10N6O2S/c1-5-2-6(13-16-5)11-7(15)3-17-8-12-10-4-14(8)9/h2,4H,3,9H2,1H3,(H,11,13,15)
  • InChiKey: OQAJNXSMFNMQAL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(4-amino-1,2,4-triazol-3-yl)sulfanyl]-N-(5-methylisoxazol-3-yl)acetamide
  • 2-[(4-amino-1,2,4-triazol-3-yl)thio]-N-(5-methyl-3-isoxazolyl)acetamide
  • 2-[(4-amino-1,2,4-triazol-3-yl)thio]-N-(5-methylisoxazol-3-yl)acetamide
  • 2-[(4-amino-1,2,4-triazol-3-yl)sulfanyl]-N-(5-methyl-1,2-oxazol-3-yl)ethanamide
  • BAS 04448240
  • 2-(4-Amino-4H-[1,2,4]triazol-3-ylsulfanyl)-N-(5-methyl-isoxazol-3-yl)-acetamide
  • ZINC01223049
  • MLS000710986
  • SMR000280753

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi jmjC domain containing protein 0.0061 0.0644 0.119
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0017 0.0031
Loa Loa (eye worm) hypothetical protein 0.0446 0.5413 1
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0225 0.0583
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0044 0.0434 0.116
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0102 0.116 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0023 0.0175 0.0295
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0017 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0017 0.0028
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0225 0.5
Echinococcus granulosus cpg binding protein 0.0031 0.0269 0.0315
Schistosoma mansoni lozenge 0.0056 0.0583 0.0668
Onchocerca volvulus 0.0084 0.0927 0.1687
Trichomonas vaginalis hypothetical protein 0.0067 0.0718 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0017 0.0031
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0086 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0017 0.0031
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0624 0.0623
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0225 0.0583
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0023 0.0175 0.0295
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0027 0.0225 0.0224
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0648 0.1874
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0017 0.0018
Trypanosoma brucei prolyl endopeptidase 0.0258 0.3082 1
Schistosoma mansoni tsg101-related 0.0093 0.1046 0.1214
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0017 0.0015
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0182 0.032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0017 0.0028
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0107 0.0124
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0648 0.4761
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0017 0.0031
Schistosoma mansoni hypothetical protein 0.0412 0.499 0.5867
Brugia malayi jmjC domain containing protein 0.0016 0.0086 0.0159
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0028
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0086 0.0082
Loa Loa (eye worm) prolyl oligopeptidase 0.0027 0.0225 0.0414
Onchocerca volvulus 0.0446 0.5413 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0225 0.0934
Entamoeba histolytica hypothetical protein 0.0024 0.0182 0.0086
Echinococcus granulosus dnaJ subfamily B 0.0412 0.499 0.5874
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0086 0.0085
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0182 0.6896
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0644 0.074
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0023 0.0175 0.0295
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0086 0.0085
Brugia malayi hypothetical protein 0.0446 0.5413 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0028
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0225 0.0465
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0648 0.0646
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0023 0.0175 0.0295
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0231 0.2747 1
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0102 0.116 0.3584
Schistosoma mansoni cpg binding protein 0.0029 0.0249 0.0274
Onchocerca volvulus 0.0029 0.0249 0.043
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0927 0.0926
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0225 0.0583
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0644 0.0757
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0086 0.0157
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0017 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0648 0.0744
Echinococcus granulosus FTZ F1 alpha 0.001 0.0017 0.0018
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0225 0.0583
Leishmania major oligopeptidase b 0.0102 0.116 0.3584
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0102 0.116 0.3584
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.499 0.4989
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0023 0.0175 0.0295
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0023 0.0175 0.0295
Loa Loa (eye worm) hypothetical protein 0.0137 0.1589 0.2933
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0023 0.0175 0.0295
Trypanosoma cruzi prolyl endopeptidase 0.0258 0.3082 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.065 0.0747
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0027 0.0225 0.0246
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0023 0.0175 0.0295
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0017 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0017 0.0031
Toxoplasma gondii prolyl endopeptidase 0.0258 0.3082 1
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0027 0.0225 0.0465
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0027 0.0225 0.0246
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0137 0.1589 0.1869
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0027 0.0225 0.0465
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0093 0.1046 1
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0086 0.0082
Loa Loa (eye worm) prolyl oligopeptidase 0.0027 0.0225 0.0414
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0644 0.074
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0182 0.032
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0027 0.0225 0.0387
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0182 0.6896
Echinococcus granulosus prolyl endopeptidase 0.0258 0.3082 0.3628
Echinococcus multilocularis cpg binding protein 0.0031 0.0269 0.0268
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0027 0.0225 0.0465
Loa Loa (eye worm) runx1 0.0056 0.0583 0.1075
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0017 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0017 0.0031
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0182 0.5
Brugia malayi nuclear hormone receptor 0.001 0.0017 0.0031
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0624 0.0716
Echinococcus granulosus Dipeptidyl peptidase 9 0.0027 0.0225 0.0264
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0157
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0157
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0017 0.0015
Echinococcus multilocularis prolyl endopeptidase 0.0258 0.3082 0.3081
Toxoplasma gondii hypothetical protein 0.0027 0.0225 0.0465
Schistosoma mansoni cpg binding protein 0.0031 0.0269 0.0298
Brugia malayi nuclear receptor NHR-88 0.001 0.0017 0.0031
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0258 0.3082 0.3616
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0017 0.0015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0017 0.0031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0157
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0023 0.0175 0.0295
Brugia malayi jmjC domain containing protein 0.0016 0.0086 0.0159
Loa Loa (eye worm) hypothetical protein 0.0084 0.0927 0.1711
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0027 0.0225 0.0465
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0086 0.0082
Echinococcus granulosus phd:f box containing protein 0.0016 0.0086 0.01
Schistosoma mansoni tsg101-related 0.0114 0.1305 0.1519
Brugia malayi jmjC domain containing protein 0.0016 0.0086 0.0159
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0102 0.116 0.3811
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0017 0.0018
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0086 0.0157
Schistosoma mansoni cpg binding protein 0.0031 0.0269 0.0298
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0225 0.0583
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0648 0.1874
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0017 0.0031
Brugia malayi CXXC zinc finger family protein 0.0029 0.0249 0.0459
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0225 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0023 0.0175 0.0295
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0023 0.0175 0.0295
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0017 0.0031
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0107 0.0105
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0027 0.0225 0.0465
Onchocerca volvulus Prolyl endopeptidase homolog 0.0258 0.3082 0.5681
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0027 0.0225 0.0224
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0927 0.1713
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0644 0.1188
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0028
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0017 0.0015
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0027 0.0225 0.0246
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0175 0.0295
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0137 0.1589 0.1587
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0225 0.5
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0927 0.109
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0182 0.5
Trypanosoma cruzi oligopeptidase b 0.0102 0.116 0.3584
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0027 0.0225 0.0465
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0017 0.0015
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0258 0.3082 0.3616
Echinococcus granulosus acylamino acid releasing enzyme 0.0027 0.0225 0.0264
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0086 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0175 0.0295
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0182 0.032
Echinococcus granulosus microtubule associated protein 2 0.0694 0.8494 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0182 0.032
Loa Loa (eye worm) hypothetical protein 0.0446 0.5413 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0028
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0028
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0044 0.0434 0.116
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0249 0.0457
Schistosoma mansoni microtubule-associated protein tau 0.0694 0.8494 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0017 0.0018
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0023 0.0175 0.0295
Brugia malayi hypothetical protein 0.0137 0.1589 0.2935
Echinococcus multilocularis microtubule associated protein 2 0.0694 0.8494 0.8494
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0017 0.0018
Brugia malayi prolyl oligopeptidase family protein 0.0258 0.3082 0.5695
Brugia malayi jmjC domain containing protein 0.0016 0.0086 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0017 0.0028
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0225 0.0416
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0017 0.0028
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0017 0.0031
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0086 0.0085
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0648 0.4761
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0027 0.0225 0.0465
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0102 0.116 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0017 0.0028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0017 0.0015
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0225 0.0416
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0182 0.5
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0648 0.1814
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0102 0.116 0.3584
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0225 0.0246
Loa Loa (eye worm) hypothetical protein 0.0258 0.3082 0.5693
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0624 0.0623
Mycobacterium tuberculosis Probable peptidase 0.0102 0.116 0.3811
Echinococcus multilocularis acylamino acid releasing enzyme 0.0027 0.0225 0.0224
Brugia malayi jmjC domain containing protein 0.0059 0.0624 0.1153
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0086 0.01
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0027 0.0225 0.0264
Brugia malayi steroid hormone receptor 0.001 0.0017 0.0031
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0086 0.0082
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0086 0.01
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0017 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0017 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0017 0.0031
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0225 0.0416
Brugia malayi ecdysteroid receptor 0.001 0.0017 0.0031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0648 0.4761
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0258 0.3082 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0017 0.0018
Trypanosoma brucei oligopeptidase b 0.0102 0.116 0.3584
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0648 0.0761
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0102 0.116 0.3584
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0027 0.0225 0.0414
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0017 0.0031
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0648 0.0744
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0017 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0017 0.0031
Plasmodium falciparum peptidase, putative 0.0027 0.0225 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0225 0.0583
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0569 0.1611
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0086 0.01
Echinococcus multilocularis Protein lozenge 0.0056 0.0583 0.0582
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0027 0.0225 0.0934
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0927 0.1074
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0027 0.0225 0.0934
Trypanosoma brucei prolyl oligopeptidase, putative 0.0102 0.116 0.3584
Loa Loa (eye worm) hypothetical protein 0.0027 0.0225 0.0414
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0017 0.0028
Leishmania major hypothetical protein, conserved 0.0044 0.0434 0.116
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0225 0.0465
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0225 0.0416
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0017 0.0028
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0017 0.0018
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0017 0.0015
Trypanosoma cruzi oligopeptidase b 0.0102 0.116 0.3584
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0624 0.0733
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0027 0.0225 0.0465
Schistosoma mansoni tsg101-related 0.0114 0.1305 0.1519

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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