Detailed information for compound 1554548

Basic information

Technical information
  • TDR Targets ID: 1554548
  • Name: 2-piperidin-1-yl-6,7-dihydro-[1,3]oxazolo[2,3 -f][1,3,5]triazin-4-one
  • MW: 222.244 | Formula: C10H14N4O2
  • H donors: 0 H acceptors: 1 LogP: 0.54 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1nc(nc2n1CCO2)N1CCCCC1
  • InChi: 1S/C10H14N4O2/c15-9-11-8(13-4-2-1-3-5-13)12-10-14(9)6-7-16-10/h1-7H2
  • InChiKey: JILRFEZKPWVOKX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(1-piperidyl)-6,7-dihydrooxazolo[2,3-f][1,3,5]triazin-4-one
  • 2-piperidino-6,7-dihydrooxazolo[2,3-f][1,3,5]triazin-4-one
  • SDCCGMLS-0018486.P002
  • BAS 13123224
  • Oprea1_439539
  • 2-Piperidin-1-yl-6,7-dihydro-oxazolo[3,2-a][1,3,5]triazin-4-one
  • 2-(1-piperidinyl)-6,7-dihydro-4H-[1,3]oxazolo[3,2-a][1,3,5]triazin-4-one
  • MLS000066051
  • SMR000079516
  • ZINC00528234

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0465 0.4495 0.4495
Schistosoma mansoni lozenge 0.0058 0.0328 0.0749
Loa Loa (eye worm) Smad1 0.0036 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.0073 0.0479 0.1095
Trypanosoma brucei hypothetical protein, conserved 0.015 0.1267 0.9048
Plasmodium falciparum ataxin-2 like protein, putative 0.0163 0.14 1
Schistosoma mansoni glutaminase 0.0371 0.3536 0.808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0222 0.0508
Echinococcus granulosus peregrin 0.0031 0.0044 0.0122
Loa Loa (eye worm) hypothetical protein 0.1002 1 1
Brugia malayi hypothetical protein 0.0163 0.14 0.14
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0073 0.0479 0.1336
Brugia malayi Calcitonin receptor-like protein seb-1 0.0663 0.6527 0.6527
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0044 0.0312
Schistosoma mansoni hypothetical protein 0.021 0.1881 0.4297
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0036 0.0094 0.0215
Schistosoma mansoni tar DNA-binding protein 0.0376 0.3587 0.8196
Echinococcus granulosus mothers against decapentaplegic 5 0.0036 0.0094 0.0262
Trypanosoma cruzi PAB1-binding protein , putative 0.0163 0.14 1
Plasmodium falciparum phd finger protein, putative 0.0031 0.0044 0.0312
Leishmania major hypothetical protein, conserved 0.015 0.1267 0.9048
Toxoplasma gondii isocitrate dehydrogenase 0.0111 0.0867 0.6195
Echinococcus granulosus tar DNA binding protein 0.0376 0.3587 1
Echinococcus granulosus lysine specific demethylase 5A 0.0099 0.0742 0.207
Schistosoma mansoni Smad4 0.0036 0.0094 0.0215
Brugia malayi MH2 domain containing protein 0.0036 0.0094 0.0094
Brugia malayi RNA binding protein 0.0376 0.3587 0.3587
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0111 0.0867 0.6195
Loa Loa (eye worm) isocitrate dehydrogenase 0.0111 0.0867 0.0867
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0378 0.0378
Brugia malayi isocitrate dehydrogenase 0.0111 0.0867 0.0867
Brugia malayi MH2 domain containing protein 0.0521 0.5073 0.5073
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0044 0.0044
Echinococcus multilocularis isocitrate dehydrogenase 0.0111 0.0867 0.2418
Loa Loa (eye worm) hypothetical protein 0.012 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0453 0.4376 0.4376
Loa Loa (eye worm) hypothetical protein 0.0663 0.6527 0.6527
Echinococcus multilocularis tar DNA binding protein 0.0376 0.3587 1
Schistosoma mansoni tar DNA-binding protein 0.0376 0.3587 0.8196
Brugia malayi TAR-binding protein 0.0376 0.3587 0.3587
Brugia malayi hypothetical protein 0.0465 0.4495 0.4495
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0167 0.0464
Brugia malayi Latrophilin receptor protein 2 0.021 0.1881 0.1881
Echinococcus granulosus smad 0.0036 0.0094 0.0262
Trypanosoma cruzi hypothetical protein, conserved 0.015 0.1267 0.9048
Schistosoma mansoni smad1 5 8 and 0.0036 0.0094 0.0215
Loa Loa (eye worm) latrophilin receptor protein 2 0.021 0.1881 0.1881
Schistosoma mansoni hypothetical protein 0.0453 0.4376 1
Trypanosoma brucei PAB1-binding protein , putative 0.0163 0.14 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0111 0.0867 0.6195
Schistosoma mansoni hypothetical protein 0.021 0.1881 0.4297
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0073 0.0479 0.1336
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0222 0.0619
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0222 0.0508
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.021 0.1881 0.5243
Brugia malayi jmjC domain containing protein 0.0162 0.139 0.139
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0044 0.0312
Brugia malayi Smad1 0.0036 0.0094 0.0094
Schistosoma mansoni jumonji domain containing protein 0.0141 0.1179 0.2694
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.0742 0.1697
Trypanosoma cruzi hypothetical protein, conserved 0.015 0.1267 0.9048
Toxoplasma gondii isocitrate dehydrogenase 0.0111 0.0867 0.6195
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0383 0.0876
Brugia malayi glutaminase DH11.1 0.0371 0.3536 0.3536
Echinococcus multilocularis peregrin 0.0031 0.0044 0.0122
Brugia malayi MH1 domain containing protein 0.0036 0.0094 0.0094
Loa Loa (eye worm) RNA binding protein 0.0376 0.3587 0.3587
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0383 0.0876
Loa Loa (eye worm) hypothetical protein 0.0163 0.14 0.14
Onchocerca volvulus 0.0465 0.4495 0.4471
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.021 0.1881 0.1881
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0376 0.3587 0.3587
Leishmania major hypothetical protein, conserved 0.0163 0.14 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0437 0.0437
Brugia malayi N-terminal motif family protein 0.012 0.0959 0.0959
Schistosoma mansoni tar DNA-binding protein 0.0376 0.3587 0.8196
Schistosoma mansoni hypothetical protein 0.021 0.1881 0.4297
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0663 0.6527 0.6527
Brugia malayi Bromodomain containing protein 0.0031 0.0044 0.0044
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0044 0.01
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0663 0.6527 0.6527
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0162 0.139 0.3876
Loa Loa (eye worm) glutaminase 2 0.0371 0.3536 0.3536
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0111 0.0867 0.6195
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0222 0.0222
Echinococcus multilocularis smad 0.0036 0.0094 0.0262
Echinococcus multilocularis GPCR, family 2 0.021 0.1881 0.5243
Loa Loa (eye worm) TAR-binding protein 0.0376 0.3587 0.3587
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0111 0.0867 0.2418
Echinococcus granulosus GPCR family 2 0.021 0.1881 0.5243
Schistosoma mansoni smad1 5 8 and 0.0036 0.0094 0.0215
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0044 0.0312
Echinococcus multilocularis Smad4 0.0036 0.0094 0.0262
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.021 0.1881 0.5243
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0222 0.0222
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0222 0.0619
Echinococcus granulosus Smad4 0.0036 0.0094 0.0262
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0162 0.139 0.3876
Trypanosoma cruzi PAB1-binding protein , putative 0.0163 0.14 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.0742 0.1697
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0111 0.0867 0.2418
Brugia malayi Isocitrate dehydrogenase 0.0111 0.0867 0.0867
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0111 0.0867 0.1982
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.012 0.0959 0.0919
Brugia malayi latrophilin 2 splice variant baaae 0.0453 0.4376 0.4376
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0111 0.0867 0.6195
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0222 0.0619
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0383 0.1069
Toxoplasma gondii LsmAD domain-containing protein 0.0163 0.14 1
Brugia malayi MH2 domain containing protein 0.0036 0.0094 0.0094
Plasmodium falciparum ataxin-2 like protein, putative 0.0163 0.14 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0036 0.0094 0.0094
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0383 0.2737
Brugia malayi RNA recognition motif domain containing protein 0.0376 0.3587 0.3587
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0383 0.2737
Mycobacterium ulcerans glutaminase 0.0371 0.3536 1
Brugia malayi MH1 domain containing protein 0.0036 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.021 0.1881 0.4297
Echinococcus multilocularis lysine specific demethylase 5A 0.0099 0.0742 0.207
Brugia malayi jmjC domain containing protein 0.0099 0.0742 0.0742
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0167 0.0464
Plasmodium vivax ataxin-2 like protein, putative 0.0163 0.14 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0044 0.0122
Loa Loa (eye worm) MH2 domain-containing protein 0.0521 0.5073 0.5073
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0111 0.0867 0.2418
Loa Loa (eye worm) hypothetical protein 0.021 0.1881 0.1881
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0044
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0044 0.0122
Echinococcus multilocularis mothers against decapentaplegic 5 0.0036 0.0094 0.0262
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0111 0.0867 0.2418
Loa Loa (eye worm) transcription factor SMAD2 0.0521 0.5073 0.5073
Brugia malayi hypothetical protein 0.0105 0.0808 0.0808
Schistosoma mansoni tar DNA-binding protein 0.0376 0.3587 0.8196
Brugia malayi PHD-finger family protein 0.0031 0.0044 0.0044
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0111 0.0867 0.6195
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0036 0.0094 0.0262
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0111 0.0867 0.6195
Loa Loa (eye worm) glutaminase 0.0371 0.3536 0.3536
Echinococcus granulosus TGF beta signal transducer SmadC 0.0036 0.0094 0.0262
Schistosoma mansoni smad1 5 8 and 0.0036 0.0094 0.0215
Schistosoma mansoni smad 0.0036 0.0094 0.0215
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.021 0.1881 0.5243
Schistosoma mansoni hypothetical protein 0.0031 0.0044 0.01
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0383 0.1069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0222 0.0619
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0111 0.0867 0.2418
Schistosoma mansoni tar DNA-binding protein 0.0376 0.3587 0.8196
Loa Loa (eye worm) hypothetical protein 0.0465 0.4495 0.4495
Onchocerca volvulus 0.1002 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.021 0.1881 0.5243
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0111 0.0867 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0099 0.0742 0.0742
Echinococcus multilocularis Protein lozenge 0.0058 0.0328 0.0914
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0111 0.0867 0.6195
Loa Loa (eye worm) runx1 0.0058 0.0328 0.0328
Giardia lamblia PHD finger protein 15 0.0031 0.0044 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0222 0.0508
Loa Loa (eye worm) MH2 domain-containing protein 0.0036 0.0094 0.0094
Trichomonas vaginalis glutaminase, putative 0.0371 0.3536 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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