Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1115 | 0.1157 |
Loa Loa (eye worm) | hypothetical protein | 0.0475 | 0.9619 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0037 | 0.0508 | 0.0527 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.3424 | 0.3554 |
Onchocerca volvulus | 0.0077 | 0.1343 | 0.5 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0077 | 0.1343 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0781 | 0.0811 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0077 | 0.1343 | 0.4916 |
Leishmania major | hypothetical protein, conserved | 0.0077 | 0.1343 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0077 | 0.1343 | 0.1343 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0077 | 0.1343 | 0.1343 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.0498 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0144 | 0.2731 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0077 | 0.1343 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.0498 | 0.3708 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0077 | 0.1343 | 0.1343 |
Mycobacterium ulcerans | lipase LipD | 0.0077 | 0.1343 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0093 | 0.1668 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0316 | 0.6311 | 0.6551 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1343 | 0.1129 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0476 | 0.9634 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.0498 | 0.3708 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0077 | 0.1343 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.1115 | 0.1157 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.1343 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0084 | 0.1474 | 0.1474 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0093 | 0.1668 | 0.1668 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0093 | 0.1668 | 0.1668 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1115 | 0.1157 |
Brugia malayi | beta-lactamase family protein | 0.0077 | 0.1343 | 0.1394 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0077 | 0.1343 | 0.1343 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1343 | 0.1129 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.0498 | 0.0223 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.1115 | 0.0885 |
Brugia malayi | Cytochrome P450 family protein | 0.0027 | 0.029 | 0.0301 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0084 | 0.1474 | 0.1474 |
Brugia malayi | beta-lactamase family protein | 0.0077 | 0.1343 | 0.1394 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.1343 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0077 | 0.1343 | 0.1394 |
Mycobacterium tuberculosis | Conserved protein | 0.0077 | 0.1343 | 0.1343 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0781 | 0.0811 |
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.0498 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0077 | 0.1343 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0077 | 0.1343 | 0.1343 |
Toxoplasma gondii | ABC1 family protein | 0.0077 | 0.1343 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0781 | 0.0811 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0084 | 0.1474 | 0.4037 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0781 | 0.0811 |
Echinococcus granulosus | geminin | 0.0177 | 0.3424 | 0.3554 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.6311 | 0.6454 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0781 | 0.0527 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.1115 | 0.1157 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1115 | 0.1157 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.0498 | 0.1823 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0077 | 0.1343 | 0.1343 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0077 | 0.1343 | 0.1394 |
Onchocerca volvulus | 0.0077 | 0.1343 | 0.5 | |
Brugia malayi | Neuronal symmetry protein 1 | 0.0476 | 0.9634 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0476 | 0.9634 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0316 | 0.6311 | 0.6551 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0077 | 0.1343 | 0.1343 |
Plasmodium vivax | hypothetical protein, conserved | 0.0077 | 0.1343 | 1 |
Treponema pallidum | NADH oxidase | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.3424 | 0.3554 |
Brugia malayi | glutathione reductase | 0.0037 | 0.0498 | 0.0517 |
Echinococcus multilocularis | muscleblind protein | 0.0316 | 0.6311 | 0.6551 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0077 | 0.1343 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0037 | 0.0508 | 0.0527 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0013 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0084 | 0.1474 | 0.1474 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.0498 | 0.3708 |
Echinococcus multilocularis | geminin | 0.0177 | 0.3424 | 0.3554 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.1115 | 0.1157 |
Schistosoma mansoni | protein kinase | 0.0476 | 0.9634 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0781 | 0.0811 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0077 | 0.1343 | 0.1129 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.1343 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0077 | 0.1343 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1343 | 0.1129 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.0498 | 0.0223 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.1115 | 0.0885 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0084 | 0.1474 | 0.1474 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0077 | 0.1343 | 0.4916 |
Mycobacterium tuberculosis | Conserved protein | 0.0077 | 0.1343 | 0.1343 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0037 | 0.0498 | 0.0498 |
Trichomonas vaginalis | esterase, putative | 0.0077 | 0.1343 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0077 | 0.1343 | 0.1394 |
Brugia malayi | RNA binding protein | 0.0066 | 0.1115 | 0.1157 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0093 | 0.1668 | 0.1668 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1343 | 0.1129 |
Schistosoma mansoni | protein kinase | 0.0476 | 0.9634 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1343 | 0.1129 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.2716 | 0.2601 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.1115 | 0.0885 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0077 | 0.1343 | 0.1394 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1343 | 0.1129 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1115 | 0.1157 |
Mycobacterium tuberculosis | Probable reductase | 0.0084 | 0.1474 | 0.1474 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.6311 | 0.6454 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0781 | 0.0811 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0144 | 0.2731 | 1 |
Leishmania major | trypanothione reductase | 0.0037 | 0.0498 | 0.3708 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1115 | 0.1157 |
Brugia malayi | Muscleblind-like protein | 0.0316 | 0.6311 | 0.6551 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0084 | 0.1474 | 0.1474 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.0498 | 0.0517 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0781 | 0.0811 |
Loa Loa (eye worm) | STE/STE11/ASK protein kinase | 0.0144 | 0.2731 | 0.2617 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0077 | 0.1343 | 0.1394 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0077 | 0.1343 | 0.1343 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0781 | 0.0811 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.0498 | 0.3708 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.1115 | 0.1157 |
Mycobacterium ulcerans | beta-lactamase | 0.0077 | 0.1343 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0077 | 0.1343 | 0.1129 |
Brugia malayi | beta-lactamase | 0.0077 | 0.1343 | 0.1394 |
Onchocerca volvulus | 0.0077 | 0.1343 | 0.5 | |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0013 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Agonist activity at PAR2 in human 16HBE14o cells assessed as activated cells at 100 uM by intracellular calcium mobilization fura-2-AM assay | ChEMBL. | 21294569 | |
Activity (functional) | Agonist activity at PAR2 in human 16HBE14o cells assessed as activated cells at 2.5 uM by intracellular calcium mobilization fura-2-AM assay | ChEMBL. | 21294569 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.