Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0022 | 0.0298 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0682 | 0.1942 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0971 | 0.0971 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0057 | 0.269 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0022 | 0.0298 | 0.0298 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0057 | 0.269 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.1649 | 0.4697 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.3467 | 0.5178 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.3467 | 0.3467 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0971 | 0.145 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0057 | 0.269 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0682 | 0.1942 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3467 | 0.5178 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.1449 | 0.4129 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.3511 | 0.3511 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.3511 | 0.5242 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.1449 | 0.8789 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0881 | 0.1316 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0971 | 0.0971 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0971 | 0.0971 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.00000060783 | 0.00000090764 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.1649 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0971 | 0.0971 |
Onchocerca volvulus | 0.003 | 0.0881 | 0.5345 | |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.3511 | 0.5242 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0022 | 0.0298 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.6697 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0971 | 0.0971 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0057 | 0.269 | 1 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0022 | 0.0298 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.3511 | 0.3511 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.00000060783 | 0.00000090764 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0057 | 0.269 | 0.4017 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.3511 | 0.3511 |
Schistosoma mansoni | transient receptor potential channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0057 | 0.269 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0298 | 0.0444 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0022 | 0.0298 | 0.0298 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0971 | 0.0971 |
Brugia malayi | methionyl-tRNA synthetase | 0.0022 | 0.0298 | 0.0444 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.1649 | 0.4697 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0022 | 0.0298 | 0.0298 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0057 | 0.269 | 1 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0022 | 0.0298 | 0.5 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0057 | 0.269 | 0.7663 |
Brugia malayi | methionyl-tRNA synthetase | 0.0057 | 0.269 | 0.4017 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.1449 | 0.4129 |
Leishmania major | leucyl-tRNA synthetase, putative | 0.0022 | 0.0298 | 0.1106 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0971 | 0.0971 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0022 | 0.0298 | 0.0298 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0057 | 0.269 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0971 | 0.0971 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0057 | 0.269 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1449 | 0.2164 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0057 | 0.269 | 0.269 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.6697 | 1 |
Brugia malayi | olfactory channel protein osm-9 | 0.0017 | 0.00000060783 | 0.00000090764 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.3511 | 0.3511 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0057 | 0.269 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.5618 | 0.839 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.3511 | 0.3511 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0035 | 0.1213 | 0.1811 |
Toxoplasma gondii | tRNA ligases class I (M) protein | 0.0022 | 0.0298 | 0.1106 |
Echinococcus multilocularis | geminin | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0971 | 0.145 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.5618 | 0.839 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.6697 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0971 | 0.145 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.1449 | 0.2164 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0971 | 0.145 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0022 | 0.0298 | 0.5 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0022 | 0.0298 | 0.0298 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0057 | 0.269 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0971 | 0.0971 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.3511 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0971 | 0.0971 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.5618 | 0.839 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0057 | 0.269 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0298 | 0.0444 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.3511 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0017 | 0.00000060783 | 0.00000060783 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0057 | 0.269 | 0.269 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.5618 | 0.839 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0298 | 0.0444 |
Onchocerca volvulus | 0.0035 | 0.1213 | 0.7356 | |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.3511 | 0.3511 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.00000060783 | 0.00000090764 |
Brugia malayi | protein ZK524.3 | 0.0022 | 0.0298 | 0.0444 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0057 | 0.269 | 0.269 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.