Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase | 0.0081 | 0.2924 | 0.4062 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.2333 | 0.324 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.0474 | 0.0485 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0474 | 0.0485 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1235 | 0.1716 |
Echinococcus multilocularis | neuroligin | 0.0024 | 0.027 | 0.0375 |
Echinococcus multilocularis | sodium channel protein | 0.004 | 0.1036 | 0.1439 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.2244 | 0.3117 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0171 | 0.7198 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1235 | 0.1716 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1235 | 0.1716 |
Leishmania major | carbonic anhydrase-like protein | 0.0171 | 0.7198 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0028 | 0.0474 | 0.0485 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.2924 | 0.2989 |
Loa Loa (eye worm) | carboxylesterase | 0.0024 | 0.027 | 0.0276 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.0998 | 0.1387 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0028 | 0.0474 | 0.0659 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.2244 | 0.2294 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0093 | 0.3516 | 0.4885 |
Brugia malayi | Bromodomain containing protein | 0.0028 | 0.0474 | 0.0485 |
Echinococcus granulosus | carbonic anhydrase | 0.0081 | 0.2924 | 0.4062 |
Schistosoma mansoni | carbonic anhydrase | 0.0081 | 0.2924 | 0.4062 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.2333 | 0.324 |
Echinococcus granulosus | peregrin | 0.0028 | 0.0474 | 0.0659 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0081 | 0.2924 | 0.2989 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.2333 | 0.324 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0024 | 0.027 | 0.0375 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0506 | 0.0704 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0171 | 0.7198 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.2924 | 0.2989 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.0928 | 0.0677 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0024 | 0.027 | 0.0375 |
Echinococcus multilocularis | acetylcholinesterase | 0.0143 | 0.5838 | 0.811 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.0998 | 0.1387 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.143 | 0.1461 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0087 | 0.321 | 0.446 |
Schistosoma mansoni | gliotactin | 0.0024 | 0.027 | 0.0375 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0024 | 0.027 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0499 | 0.051 |
Plasmodium falciparum | phd finger protein, putative | 0.0028 | 0.0474 | 0.1623 |
Onchocerca volvulus | 0.0068 | 0.2336 | 0.2123 | |
Onchocerca volvulus | 0.004 | 0.1029 | 0.0781 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0024 | 0.027 | 0.0375 |
Echinococcus multilocularis | peregrin | 0.0028 | 0.0474 | 0.0659 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.2333 | 0.324 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0024 | 0.027 | 0.0375 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0028 | 0.0474 | 0.1623 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.004 | 0.1036 | 0.1439 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.027 | 0.0276 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.2333 | 0.324 |
Toxoplasma gondii | hypothetical protein | 0.0081 | 0.2924 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0028 | 0.0474 | 0.9368 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.027 | 0.0276 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0024 | 0.027 | 0.027 |
Echinococcus granulosus | sodium channel protein | 0.004 | 0.1036 | 0.1439 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0093 | 0.3516 | 0.4885 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1235 | 0.1716 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0506 | 0.0518 |
Brugia malayi | Carboxylesterase family protein | 0.0143 | 0.5838 | 0.5968 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1235 | 0.1716 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0171 | 0.7198 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0171 | 0.7198 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1235 | 0.1263 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.2244 | 0.2294 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2244 | 0.3117 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0024 | 0.027 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0081 | 0.2924 | 0.2989 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2244 | 0.3117 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0928 | 0.0928 |
Brugia malayi | hypothetical protein | 0.0024 | 0.027 | 0.0276 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0171 | 0.7198 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0506 | 0.0704 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.027 | 0.0276 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0081 | 0.2924 | 0.4062 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1235 | 0.1263 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.027 | 0.0276 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0024 | 0.027 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0928 | 0.0949 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0034 | 0.0756 | 0.105 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0406 | 0.0406 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.004 | 0.1029 | 0.143 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0499 | 0.051 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0171 | 0.7198 | 0.7358 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0087 | 0.321 | 0.446 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0028 | 0.0474 | 0.1623 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.004 | 0.1036 | 0.1439 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0542 | 0.0554 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0028 | 0.0474 | 0.0659 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.2244 | 0.2294 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0456 | 0.0634 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0024 | 0.027 | 0.0375 |
Echinococcus multilocularis | acetylcholinesterase | 0.0143 | 0.5838 | 0.811 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2244 | 0.3117 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0081 | 0.2924 | 0.2989 |
Echinococcus granulosus | acetylcholinesterase | 0.0143 | 0.5838 | 0.811 |
Schistosoma mansoni | acetylcholinesterase | 0.0024 | 0.027 | 0.0375 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.1898 | 0.194 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0506 | 0.1732 |
Brugia malayi | RNA binding protein | 0.0066 | 0.2244 | 0.2294 |
Echinococcus multilocularis | carbonic anhydrase | 0.0081 | 0.2924 | 0.4062 |
Echinococcus granulosus | carbonic anhydrase II | 0.0171 | 0.7198 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0143 | 0.5838 | 0.811 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0506 | 0.0704 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0143 | 0.5838 | 0.5968 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.027 | 0.0375 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0024 | 0.027 | 0.027 |
Brugia malayi | Carboxylesterase family protein | 0.0143 | 0.5838 | 0.5968 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.027 | 0.0276 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0.027 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0081 | 0.2924 | 0.4062 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1235 | 0.1716 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.027 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0506 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.027 | 0.0276 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0034 | 0.0756 | 0.105 |
Brugia malayi | Pre-SET motif family protein | 0.0203 | 0.8681 | 0.8874 |
Schistosoma mansoni | jumonji domain containing protein | 0.0074 | 0.2616 | 0.3635 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.027 | 0.0375 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0226 | 0.9783 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0171 | 0.7198 | 0.7358 |
Brugia malayi | jmjC domain containing protein | 0.0034 | 0.0756 | 0.0773 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0028 | 0.0474 | 0.0659 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0171 | 0.7198 | 0.7358 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0034 | 0.0756 | 0.0773 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0506 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0024 | 0.027 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0171 | 0.7198 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.2244 | 0.2294 |
Echinococcus multilocularis | jun protein | 0.0087 | 0.321 | 0.446 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.2924 | 0.2989 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0203 | 0.8681 | 0.8874 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.2447 | 0.34 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.027 | 0.0276 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.2244 | 0.2294 |
Brugia malayi | jmjC domain containing protein | 0.0093 | 0.3516 | 0.3594 |
Loa Loa (eye worm) | carboxylesterase | 0.0024 | 0.027 | 0.0276 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.027 | 0.0276 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.2924 | 0.4062 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0081 | 0.2924 | 0.4062 |
Brugia malayi | bZIP transcription factor family protein | 0.0087 | 0.321 | 0.3281 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2244 | 0.3117 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5838 | 0.5968 |
Brugia malayi | follicle stimulating hormone receptor | 0.0226 | 0.9783 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.0928 | 0.0949 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2244 | 0.3117 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0024 | 0.027 | 0.0375 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0928 | 0.0928 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.5838 | 0.5968 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0081 | 0.2924 | 0.4062 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.027 | 0.0276 |
Brugia malayi | hypothetical protein | 0.0068 | 0.2336 | 0.2387 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1235 | 0.1716 |
Echinococcus granulosus | neuroligin | 0.0024 | 0.027 | 0.0375 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0756 | 0.105 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.2333 | 0.2333 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.2244 | 0.3117 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0506 | 0.0704 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.0756 | 0.105 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.1064 | 0.0817 |
Echinococcus granulosus | jun protein | 0.0087 | 0.321 | 0.446 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0171 | 0.7198 | 0.7358 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0506 | 0.0704 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0506 | 0.0704 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0024 | 0.027 | 0.0375 |
Onchocerca volvulus | Alhambra homolog | 0.0028 | 0.0474 | 0.021 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0027 | 0.0406 | 0.0406 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.2333 | 0.2333 |
Onchocerca volvulus | 0.003 | 0.0542 | 0.0279 | |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0081 | 0.2924 | 0.2989 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0081 | 0.2924 | 0.2989 |
Schistosoma mansoni | jun-related protein | 0.007 | 0.2447 | 0.34 |
Brugia malayi | Heterochromatin protein 1 | 0.0068 | 0.2333 | 0.2384 |
Loa Loa (eye worm) | carboxylesterase | 0.0143 | 0.5838 | 0.5968 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0474 | 0.0659 |
Echinococcus multilocularis | carbonic anhydrase | 0.0081 | 0.2924 | 0.4062 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0024 | 0.027 | 0.0375 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0143 | 0.5838 | 0.811 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0068 | 0.2333 | 0.2384 |
Plasmodium falciparum | carbonic anhydrase | 0.0081 | 0.2924 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0231 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0024 | 0.027 | 0.0276 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0081 | 0.2924 | 0.2989 |
Echinococcus granulosus | carboxylesterase 5A | 0.0143 | 0.5838 | 0.811 |
Giardia lamblia | PHD finger protein 15 | 0.0028 | 0.0474 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0143 | 0.5838 | 0.811 |
Echinococcus multilocularis | carbonic anhydrase | 0.0081 | 0.2924 | 0.4062 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.2333 | 0.324 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.3098 | 0.3167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.