Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0031 | 0.0322 | 0.5 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0052 | 0.0753 | 0.3697 |
Onchocerca volvulus | 0.0102 | 0.1756 | 1 | |
Schistosoma mansoni | sex comb on midleg homolog | 0.0102 | 0.1756 | 0.1526 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0031 | 0.0322 | 0.5 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0116 | 0.2037 | 0.2601 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0116 | 0.2037 | 0.5 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0116 | 0.2037 | 1 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0102 | 0.1756 | 0.2186 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0092 | 0.1559 | 0.1897 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0031 | 0.0322 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0271 | 0.1328 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0271 | 0.1328 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.026 | 0.1276 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0116 | 0.2037 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0116 | 0.2037 | 0.1816 |
Brugia malayi | mbt repeat family protein | 0.0092 | 0.1559 | 0.7655 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0116 | 0.2037 | 0.5 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0116 | 0.2037 | 0.2601 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0116 | 0.2037 | 0.5 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0031 | 0.0322 | 0.5 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0092 | 0.1559 | 0.1325 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0092 | 0.1559 | 0.8679 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0363 | 0.7063 | 1 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0031 | 0.0322 | 0.5 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0116 | 0.2037 | 1 |
Loa Loa (eye worm) | MBCTL1 | 0.0052 | 0.0753 | 0.3697 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0116 | 0.2037 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0753 | 0.3697 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0116 | 0.2037 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0271 | 0.1328 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0116 | 0.2037 | 1 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0116 | 0.2037 | 0.1816 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0116 | 0.2037 | 0.5 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0052 | 0.0753 | 0.071 |
Brugia malayi | mbt repeat family protein | 0.0092 | 0.1559 | 0.7655 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0116 | 0.2037 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0052 | 0.0753 | 0.071 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0031 | 0.0322 | 0.5 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0102 | 0.1756 | 0.1526 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0031 | 0.0322 | 0.5 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0116 | 0.2037 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0116 | 0.2037 | 1 |
Brugia malayi | 6-phosphofructokinase | 0.0116 | 0.2037 | 1 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0031 | 0.0322 | 0.5 |
Brugia malayi | phosphofructokinase | 0.0116 | 0.2037 | 1 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0116 | 0.2037 | 1 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0116 | 0.2037 | 1 |
Loa Loa (eye worm) | phosphofructokinase | 0.0116 | 0.2037 | 1 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0052 | 0.0753 | 0.0496 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0271 | 0.1328 |
Schistosoma mansoni | hypothetical protein | 0.0314 | 0.6054 | 0.5944 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0363 | 0.7063 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0116 | 0.2037 | 1 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0031 | 0.0322 | 0.5 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0052 | 0.0753 | 0.071 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0116 | 0.2037 | 0.5 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0092 | 0.1559 | 0.1897 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.0314 | 0.6054 | 0.8515 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0102 | 0.1756 | 0.2186 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0031 | 0.0322 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0271 | 0.1328 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1559 | 0.7655 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0092 | 0.1559 | 0.7655 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0052 | 0.0753 | 0.071 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.0314 | 0.6054 | 0.8515 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | ChEMBL. | 21903399 | |
Inhibition (binding) | Inhibition of recombinant His-tagged human DNA polymerase lambda using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | ChEMBL. | 21903399 | |
Inhibition (binding) | Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using bovine deoxyribonuclease 1-treated DNA and dNTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | ChEMBL. | 21903399 | |
Inhibition (binding) | Inhibition of recombinant His-tagged human DNA polymerase lambda using bovine deoxyribonuclease 1-treated DNA and dNTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins | ChEMBL. | 21903399 | |
LD50 (ADMET) | > 10 uM | Cytotoxicity against mouse RAW264.7 cells | ChEMBL. | 21903399 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.