TDR Targets

Basic information

Technical information

TDR Targets ID: 1568323
Name: 1-(4-imidazol-1-ylphenyl)imidazole
MW: 210.235 | Formula: C12H10N4
H donors: 0 H acceptors: 2 LogP: 1.42 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: c1ncn(c1)c1ccc(cc1)n1cncc1
InChi: 1S/C12H10N4/c1-2-12(16-8-6-14-10-16)4-3-11(1)15-7-5-13-9-15/h1-10H
InChiKey: JWPDUQLIPMJLOF-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

1-[4-(1-imidazolyl)phenyl]imidazole
25372-07-0

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0107	0.5
Mycobacterium ulcerans	putative regulatory protein	0.0037	0.0704	0.5246
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0156	0.4645	0.4645
Schistosoma mansoni	hypothetical protein	0.0174	0.5244	0.5244
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0054	0.1245	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0107	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0483	0.0483
Brugia malayi	hypothetical protein	0.0054	0.1245	0.1245
Brugia malayi	Carboxylesterase family protein	0.0054	0.1245	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1245	0.1245
Brugia malayi	Carboxylesterase family protein	0.0317	1	1
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0054	0.1245	0.1245
Brugia malayi	Pre-SET motif family protein	0.0214	0.6563	0.6563
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3819	0.3819
Loa Loa (eye worm)	hypothetical protein	0.0317	1	1
Brugia malayi	hypoxia-induced factor 1	0.0156	0.4645	0.4645
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0393	0.0393
Echinococcus granulosus	geminin	0.0174	0.5244	0.5244
Echinococcus multilocularis	carboxylesterase 5A	0.0317	1	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0107	1
Mycobacterium ulcerans	carboxylesterase, LipT	0.0054	0.1245	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.1299	0.1299
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0376	0.0376
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0214	0.6563	0.6563
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1299	0.1299
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1299	0.1299
Schistosoma mansoni	aryl hydrocarbon receptor	0.005	0.1139	0.1139
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0054	0.1245	1
Plasmodium vivax	SET domain protein, putative	0.0031	0.0483	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0393	0.0393
Echinococcus granulosus	lamin dm0	0.0028	0.0393	0.0393
Onchocerca volvulus		0.0243	0.7544	1
Brugia malayi	intermediate filament protein	0.0028	0.0393	0.0393
Echinococcus multilocularis	neuroligin	0.0054	0.1245	0.1245
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0483	0.0483
Schistosoma mansoni	ap endonuclease	0.0019	0.0107	0.0107
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0054	0.1245	0.1531
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.1471	0.1471
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0317	1	1
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0393	0.0393
Loa Loa (eye worm)	acetylcholinesterase 1	0.0317	1	1
Brugia malayi	Pre-SET motif family protein	0.0031	0.0483	0.0483
Echinococcus granulosus	para nitrobenzyl esterase	0.0054	0.1245	0.1245
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.006	0.1471	0.1471
Loa Loa (eye worm)	hypothetical protein	0.0169	0.508	0.508
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0107	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1245	0.1245
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0107	0.0107
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0054	0.1245	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1245	0.1245
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1299	0.1299
Schistosoma mansoni	hypothetical protein	0.0174	0.5244	0.5244
Onchocerca volvulus		0.0054	0.1245	0.1192
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0483	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3819	0.3819
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0054	0.1245	0.1245
Echinococcus multilocularis	acetylcholinesterase	0.0317	1	1
Brugia malayi	jmjC domain containing protein	0.006	0.1471	0.1471
Trichomonas vaginalis	spcc417.12 protein, putative	0.0054	0.1245	0.1531
Echinococcus multilocularis	acetylcholinesterase	0.0317	1	1
Schistosoma mansoni	jumonji domain containing protein	0.006	0.1471	0.1471
Brugia malayi	Carboxylesterase family protein	0.0054	0.1245	0.1245
Echinococcus granulosus	intermediate filament protein	0.0028	0.0393	0.0393
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0107	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1299	0.1299
Loa Loa (eye worm)	carboxylesterase	0.0054	0.1245	0.1245
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.1299	0.1299
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0107	0.2204
Brugia malayi	bHLH-PAS transcription factor	0.0037	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1245	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1245	0.1245
Schistosoma mansoni	BC026374 protein (S09 family)	0.0054	0.1245	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0483	0.0483
Echinococcus multilocularis	serotonin receptor	0.0131	0.3819	0.3819
Schistosoma mansoni	lamin	0.0028	0.0393	0.0393
Echinococcus multilocularis	geminin	0.0174	0.5244	0.5244
Onchocerca volvulus		0.0031	0.0483	0.0126
Onchocerca volvulus		0.0054	0.1245	0.1192
Echinococcus granulosus	acetylcholinesterase	0.0317	1	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1245	0.1245
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0107	0.5
Brugia malayi	hypothetical protein	0.0169	0.508	0.508
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0483	0.0483
Toxoplasma gondii	exonuclease III APE	0.0019	0.0107	0.2204
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0483	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.1471	0.1471
Echinococcus multilocularis	lysine specific demethylase 5A	0.006	0.1471	0.1471
Schistosoma mansoni	single-minded	0.005	0.1139	0.1139
Echinococcus multilocularis	transfer RNA-Lys	0.0037	0.0704	0.0704
Onchocerca volvulus		0.0054	0.1245	0.1192
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0393	0.0393
Echinococcus granulosus	carboxylesterase 5A	0.0317	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1299	0.1299
Schistosoma mansoni	gliotactin	0.0054	0.1245	0.1245
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0107	1
Echinococcus multilocularis	serotonin receptor	0.0131	0.3819	0.3819
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1245	0.1245
Schistosoma mansoni	ap endonuclease	0.0019	0.0107	0.0107
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1299	0.1299
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0107	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.006	0.1471	0.1471
Echinococcus multilocularis	musashi	0.0028	0.0393	0.0393
Echinococcus multilocularis	para nitrobenzyl esterase	0.0054	0.1245	0.1245
Schistosoma mansoni	lamin	0.0028	0.0393	0.0393
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0107	0.0107
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0054	0.1245	0.1245
Echinococcus granulosus	single minded 2	0.0037	0.0704	0.0704
Brugia malayi	Carboxylesterase family protein	0.0054	0.1245	0.1245
Onchocerca volvulus		0.0054	0.1245	0.1192
Schistosoma mansoni	acetylcholinesterase	0.0054	0.1245	0.1245
Trichomonas vaginalis	set domain proteins, putative	0.0243	0.7544	1
Loa Loa (eye worm)	carboxylesterase	0.0054	0.1245	0.1245
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0054	0.1245	0.1245
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0483	0.0483
Echinococcus multilocularis	lamin	0.0028	0.0393	0.0393
Onchocerca volvulus		0.0054	0.1245	0.1192
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0107	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1299	0.1299
Echinococcus granulosus	lamin	0.0028	0.0393	0.0393
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0483	0.0483
Echinococcus granulosus	biogenic amine 5HT receptor	0.0131	0.3819	0.3819
Brugia malayi	Carboxylesterase family protein	0.0054	0.1245	0.1245
Loa Loa (eye worm)	carboxylesterase	0.0317	1	1
Loa Loa (eye worm)	hypothetical protein	0.0317	1	1
Brugia malayi	jmjC domain containing protein	0.006	0.1471	0.1471
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0054	0.1245	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0483	0.0483
Echinococcus granulosus	neuroligin	0.0054	0.1245	0.1245
Echinococcus multilocularis	lamin dm0	0.0028	0.0393	0.0393
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0446	0.0446
Onchocerca volvulus		0.0037	0.0704	0.0435
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.1471	0.1471
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0107	0.0107
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0054	0.1245	0.1245
Echinococcus granulosus	acetylcholinesterase	0.0317	1	1
Brugia malayi	PAS domain containing protein	0.005	0.1139	0.1139
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0131	0.3819	0.3819
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0054	0.1245	0.1245
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0107	0.5
Echinococcus granulosus	lysine specific demethylase 5A	0.006	0.1471	0.1471
Echinococcus granulosus	BC026374 protein S09 family	0.0054	0.1245	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0393	0.0393

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 93 uM	Antiplasmodial activity against Plasmodium falciparum assessed as inhibition of parasite LDH activity after 72 hrs	ChEMBL.	21944972

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1923919

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1568323