TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 596.84 | Formula: C36H56N2O5
H donors: 4 H acceptors: 5 LogP: 6.92 Rotable bonds: 19
Rule of 5 violations (Lipinski): 2
SMILES: O=C(CNC(=O)CCC(=O)C)NCCCCCCCCCCC[C@@H]1Cc2cc(O)ccc2C2C1C1CC[C@@H]([C@@]1(CC2)C)O
InChi: 1S/C36H56N2O5/c1-25(39)13-18-33(42)38-24-34(43)37-21-11-9-7-5-3-4-6-8-10-12-26-22-27-23-28(40)14-15-29(27)30-19-20-36(2)31(35(26)30)16-17-32(36)41/h14-15,23,26,30-32,35,40-41H,3-13,16-22,24H2,1-2H3,(H,37,43)(H,38,42)/t26-,30?,31?,32+,35?,36+/m1/s1
InChiKey: SZBLESSJAGFWOE-NNEFAMGFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0097	0.0447	0.1534
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0282	0.034
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0431	0.268	0.3767
Brugia malayi	Matrixin family protein	0.1094	0.7116	1
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0452	0.2821	0.3965
Brugia malayi	intermediate filament protein	0.0056	0.0175	0.0246
Leishmania major	cysteine peptidase A (CPA)	0.0059	0.0191	0.0279
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.0191	0.123
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0431	0.268	1
Onchocerca volvulus		0.0056	0.0175	0.0173
Onchocerca volvulus	Cathepsin L homolog	0.0059	0.0191	0.0198
Echinococcus granulosus	carbonic anhydrase II	0.0834	0.5382	0.5382
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0059	0.0191	0.0191
Onchocerca volvulus		0.0097	0.0447	0.0586
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0097	0.0447	0.0685
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.0191	0.123
Brugia malayi	Thioredoxin reductase	0.0037	0.0042	0.0059
Trypanosoma brucei	carbonic anhydrase-like protein	0.0834	0.5382	1
Echinococcus multilocularis	cytosolic malate dehydrogenase	0.0263	0.1555	0.1555
Loa Loa (eye worm)	ctsf protein	0.0059	0.0191	0.0211
Trichomonas vaginalis	malate dehydrogenase, putative	0.0237	0.138	0.8876
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0061	0.0026
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0834	0.5382	1
Leishmania major	cathepsin L-like protease	0.0059	0.0191	0.0279
Brugia malayi	Hemopexin family protein	0.0502	0.3154	0.4432
Trypanosoma cruzi	cytosolic malate dehydrogenase, putative	0.0263	0.1555	0.2889
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0785	0.5048	0.7577
Trichomonas vaginalis	malate dehydrogenase, putative	0.0263	0.1555	1
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0263	0.1555	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0452	0.2821	0.3965
Echinococcus granulosus	carbonic anhydrase	0.0452	0.2821	0.2821
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0093	0.0419	0.1428
Brugia malayi	Cathepsin L-like precursor	0.0059	0.0191	0.0269
Echinococcus granulosus	carbonic anhydrase	0.0452	0.2821	0.2821
Echinococcus multilocularis	musashi	0.0056	0.0175	0.0175
Trypanosoma cruzi	major cysteine proteinase, putative	0.0108	0.0519	0.0964
Trypanosoma brucei	trypanothione reductase	0.0037	0.0042	0.0078
Echinococcus granulosus	malate dehydrogenase	0.0256	0.1507	0.1507
Brugia malayi	Probable malate dehydrogenase, mitochondrial precursor	0.0256	0.1507	0.2118
Trichomonas vaginalis	malate dehydrogenase, putative	0.0263	0.1555	1
Plasmodium vivax	glutathione reductase, putative	0.0037	0.0042	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0282	0.034
Onchocerca volvulus	Cathepsin F homolog	0.0059	0.0191	0.0198
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.0191	0.123
Trichomonas vaginalis	malate dehydrogenase, putative	0.0263	0.1555	1
Echinococcus multilocularis	cysteine protease	0.0059	0.0191	0.0191
Schistosoma mansoni	malate dehydrogenase	0.0263	0.1555	0.2889
Loa Loa (eye worm)	matrixin family protein	0.1094	0.7116	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0073	0.0282	0.0814
Toxoplasma gondii	lactate dehydrogenase LDH1	0.0549	0.3471	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0191	0.123
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0452	0.2821	0.3929
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.0191	0.123
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.0191	0.123
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0191	0.123
Echinococcus multilocularis	lactate dehydrogenase a	0.0549	0.3471	0.3471
Plasmodium falciparum	carbonic anhydrase	0.0452	0.2821	0.8129
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0059	0.0191	0.123
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0175	0.0187
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0059	0.0191	0.0211
Schistosoma mansoni	carbonic anhydrase-related	0.0452	0.2821	0.5242
Onchocerca volvulus		0.0059	0.0191	0.0198
Onchocerca volvulus		0.0502	0.3154	0.4699
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0037	0.0045	0.0045
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0834	0.5382	1
Echinococcus granulosus	lactate dehydrogenase protein	0.0549	0.3471	0.3471
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0263	0.1555	1
Trichomonas vaginalis	malate dehydrogenase, putative	0.0263	0.1555	1
Entamoeba histolytica	malate dehydrogenase,cytoplasmic, putative	0.0263	0.1555	0.448
Trypanosoma cruzi	cysteine peptidase, putative	0.0156	0.0841	0.1562
Trypanosoma brucei	glycosomal malate dehydrogenase	0.0256	0.1507	0.28
Loa Loa (eye worm)	hypothetical protein	0.0452	0.2821	0.3929
Giardia lamblia	Malate dehydrogenase	0.0263	0.1555	0.5
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0073	0.0282	0.0911
Onchocerca volvulus		0.0059	0.0191	0.0198
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0452	0.2821	0.3965
Echinococcus granulosus	malate dehydrogenase	0.0256	0.1507	0.1507
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0093	0.0419	0.0269
Echinococcus multilocularis	malate dehydrogenase	0.0256	0.1507	0.1507
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0097	0.0447	0.1287
Brugia malayi	Matrixin family protein	0.0354	0.2164	0.3042
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.1524	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0156	0.0841	0.1562
Onchocerca volvulus	Cathepsin L homolog	0.0059	0.0191	0.0198
Schistosoma mansoni	carbonic anhydrase-related	0.0452	0.2821	0.5242
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0061	0.0026
Plasmodium falciparum	acyl-CoA synthetase	0.0073	0.0282	0.0814
Loa Loa (eye worm)	fibroinase	0.0059	0.0191	0.0211
Leishmania major	cathepsin L-like protease	0.0059	0.0191	0.0279
Schistosoma mansoni	L-lactate dehydrogenase	0.0237	0.138	0.2564
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0156	0.0841	0.1562
Plasmodium vivax	vivapain-2	0.0059	0.0191	0.0551
Loa Loa (eye worm)	hypothetical protein	0.0549	0.3471	0.4847
Trypanosoma cruzi	glycosomal malate dehydrogenase, putative	0.0256	0.1507	0.28
Brugia malayi	Cathepsin L-like precursor	0.0059	0.0191	0.0269
Trichomonas vaginalis	malate dehydrogenase, putative	0.0263	0.1555	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0059	0.0191	0.0551
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0191	0.123
Mycobacterium tuberculosis	Probable malate dehydrogenase Mdh	0.0263	0.1555	0.5734
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0191	0.123
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0263	0.1555	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0093	0.0419	0.1428
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0061	0.0026
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.0191	0.0355
Mycobacterium tuberculosis	Probable reductase	0.0084	0.0356	0.1191
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0191	0.123
Echinococcus multilocularis	cathepsin L cysteine protease	0.0059	0.0191	0.0191
Trypanosoma cruzi	glycosomal malate dehydrogenase, putative	0.0256	0.1507	0.28
Schistosoma mansoni	cathepsin F (C01 family)	0.0039	0.0061	0.0113
Trypanosoma brucei	malate dehydrogenase-related	0.0237	0.138	0.2564
Echinococcus multilocularis	lactate dehydrogenase a	0.0549	0.3471	0.3471
Loa Loa (eye worm)	intermediate filament protein	0.0056	0.0175	0.0187
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.0191	0.123
Leishmania major	cathepsin L-like protease	0.0059	0.0191	0.0279
Echinococcus granulosus	cytosolic malate dehydrogenase	0.0263	0.1555	0.1555
Onchocerca volvulus		0.0059	0.0191	0.0198
Toxoplasma gondii	lactate dehydrogenase LDH2	0.0549	0.3471	1
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0834	0.5382	1
Onchocerca volvulus		0.0059	0.0191	0.0198
Brugia malayi	AMP-binding enzyme family protein	0.0097	0.0447	0.0628
Trichomonas vaginalis	malate dehydrogenase, putative	0.0263	0.1555	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0097	0.0447	0.1534
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.0191	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0447	0.0572
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0069	0.0256	0.081
Mycobacterium ulcerans	acyl-CoA synthetase	0.0097	0.0447	0.0685
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0191	0.123
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0097	0.0447	0.0685
Schistosoma mansoni	carbonic anhydrase-related	0.0452	0.2821	0.5242
Brugia malayi	lactate dehydrogenase.	0.0549	0.3471	0.4878
Leishmania major	cathepsin L-like protease	0.0156	0.0841	0.1496
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0263	0.1555	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0061	0.0391
Plasmodium vivax	vivapain-2	0.0059	0.0191	0.0551
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0069	0.0256	0.081
Entamoeba histolytica	cysteine protease, putative	0.0059	0.0191	0.0551
Loa Loa (eye worm)	hypothetical protein	0.0431	0.268	0.373
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0059	0.0191	0.0191
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0185	0.1035	0.1923
Plasmodium vivax	lactate dehydrogenase	0.0549	0.3471	1
Mycobacterium ulcerans	hydrolase	0.0431	0.268	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0097	0.0447	0.0685
Brugia malayi	Matrixin family protein	0.0354	0.2164	0.3042
Echinococcus multilocularis	cytosolic malate dehydrogenase	0.0263	0.1555	0.1555
Loa Loa (eye worm)	matrixin family protein	0.0785	0.5048	0.7076
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0834	0.5382	0.7563
Trichomonas vaginalis	malate dehydrogenase, putative	0.0263	0.1555	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0097	0.0447	0.0758
Schistosoma mansoni	malate dehydrogenase	0.0263	0.1555	0.2889
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0084	0.0356	0.1191
Plasmodium falciparum	lactate dehydrogenase, putative	0.0237	0.138	0.3976
Toxoplasma gondii	malate dehydrogenase MDH	0.0549	0.3471	1
Loa Loa (eye worm)	hypothetical protein	0.0592	0.3759	0.5254
Trypanosoma cruzi	cytosolic malate dehydrogenase, putative	0.0263	0.1555	0.2889
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.0042	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0447	0.0572
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0059	0.0191	0.123
Toxoplasma gondii	cathepsin CPL	0.0059	0.0191	0.0435
Echinococcus multilocularis	cysteine protease	0.0059	0.0191	0.0191
Echinococcus multilocularis	lamin	0.0056	0.0175	0.0175
Echinococcus granulosus	lactate dehydrogenase a	0.0549	0.3471	0.3471
Mycobacterium ulcerans	hypothetical protein	0.0097	0.0447	0.0685
Schistosoma mansoni	malate dehydrogenase	0.0256	0.1507	0.28
Leishmania major	4-coumarate:coa ligase-like protein	0.0097	0.0447	0.0758
Onchocerca volvulus		0.0059	0.0191	0.0198
Loa Loa (eye worm)	malate dehydrogenase	0.0263	0.1555	0.2139
Brugia malayi	Intermediate filament tail domain containing protein	0.0056	0.0175	0.0246
Brugia malayi	Matrixin family protein	0.0354	0.2164	0.3042
Trichomonas vaginalis	malate dehydrogenase, putative	0.0263	0.1555	1
Echinococcus multilocularis	L lactate dehydrogenase B chain	0.0549	0.3471	0.3471
Echinococcus multilocularis	lactate dehydrogenase protein	0.0549	0.3471	0.3471
Leishmania major	mitochondrial malate dehydrogenase	0.0256	0.1507	0.2744
Onchocerca volvulus	Matrilysin homolog	0.0354	0.2164	0.3196
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0191	0.123
Echinococcus multilocularis	malate dehydrogenase	0.0256	0.1507	0.1507
Echinococcus multilocularis	carbonic anhydrase	0.0452	0.2821	0.2821
Echinococcus granulosus	L lactate dehydrogenase B chain	0.0549	0.3471	0.3471
Leishmania major	carbonic anhydrase-like protein	0.0834	0.5382	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.0191	0.123
Brugia malayi	Matrixin family protein	0.0354	0.2164	0.3042
Loa Loa (eye worm)	hypothetical protein	0.0354	0.2164	0.3
Toxoplasma gondii	hypothetical protein	0.0452	0.2821	0.8106
Echinococcus granulosus	lamin dm0	0.0056	0.0175	0.0175
Plasmodium falciparum	thioredoxin reductase	0.0037	0.0042	0.0121
Leishmania major	cathepsin L-like protease	0.0059	0.0191	0.0279
Leishmania major	glycosomal malate dehydrogenase	0.0256	0.1507	0.2744
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0097	0.0447	0.0388
Entamoeba histolytica	malate dehydrogenase, putative	0.0263	0.1555	0.448
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0156	0.0841	0.1562
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.0191	0.0551
Echinococcus granulosus	intermediate filament protein	0.0056	0.0175	0.0175
Onchocerca volvulus		0.0056	0.0175	0.0173
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0059	0.0191	0.0551
Echinococcus granulosus	lactate dehydrogenase a	0.0549	0.3471	0.3471
Echinococcus multilocularis	L lactate dehydrogenase	0.0312	0.1888	0.1888
Schistosoma mansoni	intermediate filament proteins	0.0056	0.0175	0.0325
Echinococcus granulosus	L lactate dehydrogenase	0.0312	0.1888	0.1888
Plasmodium falciparum	glutathione reductase	0.0037	0.0042	0.0121
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0084	0.0356	0.1191
Trypanosoma brucei	mitochondrial malate dehydrogenase	0.0256	0.1507	0.28
Schistosoma mansoni	lamin	0.0056	0.0175	0.0325
Onchocerca volvulus		0.0059	0.0191	0.0198
Echinococcus multilocularis	cathepsin L cysteine protease	0.0059	0.0191	0.0191
Brugia malayi	AMP-binding enzyme family protein	0.0097	0.0447	0.0628
Echinococcus multilocularis	lamin dm0	0.0056	0.0175	0.0175
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0156	0.0841	0.1562
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0097	0.0447	0.0685
Entamoeba histolytica	acyl-coA synthetase, putative	0.0097	0.0447	0.1287
Onchocerca volvulus		0.0354	0.2164	0.3196
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0191	0.123
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0097	0.0447	0.0388
Trichomonas vaginalis	malate dehydrogenase, putative	0.0141	0.0743	0.4778
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0059	0.0191	0.0191
Echinococcus granulosus	thioredoxin glutathione reductase	0.0037	0.0045	0.0045
Brugia malayi	Cathepsin L-like precursor	0.0059	0.0191	0.0269
Mycobacterium tuberculosis	Probable dehydrogenase	0.0084	0.0356	0.1191
Trichomonas vaginalis	malate dehydrogenase, putative	0.0263	0.1555	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0061	0.0391
Trypanosoma cruzi	mitochondrial malate dehydrogenase, putative	0.0256	0.1507	0.28
Mycobacterium ulcerans	malate dehydrogenase	0.0263	0.1555	0.5307
Brugia malayi	Cathepsin L-like precursor	0.0059	0.0191	0.0269
Brugia malayi	glutathione reductase	0.0037	0.0042	0.0059
Brugia malayi	AMP-binding enzyme family protein	0.0097	0.0447	0.0628
Mycobacterium leprae	PROBABLE MALATE DEHYDROGENASE MDH	0.0263	0.1555	0.5157
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.0191	0.0355
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0191	0.123
Echinococcus multilocularis	carbonic anhydrase II	0.0834	0.5382	0.5382
Loa Loa (eye worm)	hypothetical protein	0.0354	0.2164	0.3
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0093	0.0419	0.1428
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0136	0.071	0.132
Trichomonas vaginalis	malate dehydrogenase, putative	0.0115	0.0568	0.3654
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0191	0.0211
Plasmodium falciparum	L-lactate dehydrogenase	0.0549	0.3471	1
Loa Loa (eye worm)	carbonic anhydrase 3	0.0834	0.5382	0.7549
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0168	0.0178
Trypanosoma cruzi	malate dehydrogenase, putative	0.0237	0.138	0.2564
Echinococcus granulosus	cathepsin l1	0.0059	0.0191	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0282	0.034
Trypanosoma cruzi	trypanothione reductase, putative	0.0037	0.0042	0.0078
Brugia malayi	Malate dehydrogenase, cytoplasmic	0.0263	0.1555	0.2185
Schistosoma mansoni	carbonic anhydrase	0.0452	0.2821	0.5242
Loa Loa (eye worm)	hypothetical protein	0.0452	0.2821	0.3929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0156	0.0841	0.1562
Brugia malayi	Cathepsin L-like precursor	0.0039	0.0061	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0447	0.0572
Leishmania major	malate dehydrogenase, putative	0.0549	0.3471	0.6421
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0097	0.0447	0.1287
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0097	0.0447	0.0685
Leishmania major	cathepsin L-like protease	0.0156	0.0841	0.1496
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0056	0.0175	0.0187
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0156	0.0841	0.1562
Loa Loa (eye worm)	malate dehydrogenase	0.0256	0.1507	0.2071
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0084	0.0356	0.1191
Trichomonas vaginalis	malate dehydrogenase, putative	0.0263	0.1555	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0039	0.0061	0.0086
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0059	0.0191	0.0211
Onchocerca volvulus	Matrilysin homolog	0.1023	0.6643	1
Loa Loa (eye worm)	cysteine protease	0.0059	0.0191	0.0211
Schistosoma mansoni	lamin	0.0056	0.0175	0.0325
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0834	0.5382	0.7563
Leishmania major	malate dehydrogenase	0.0256	0.1507	0.2744
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0834	0.5382	1
Trypanosoma cruzi	malate dehydrogenase, putative	0.0256	0.1507	0.28
Trypanosoma cruzi	cysteine peptidase, putative	0.0156	0.0841	0.1562
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.0191	0.123
Chlamydia trachomatis	malate dehydrogenase	0.0263	0.1555	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0452	0.2821	0.3965
Wolbachia endosymbiont of Brugia malayi	malate dehydrogenase	0.0549	0.3471	0.5
Plasmodium vivax	malate dehydrogenase, putative	0.0549	0.3471	1
Plasmodium vivax	lactate/malate dehydrogenase, putative	0.0237	0.138	0.3976
Mycobacterium ulcerans	acyl-CoA synthetase	0.0097	0.0447	0.0685
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0282	0.034
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0282	0.034
Trichomonas vaginalis	malate dehydrogenase, putative	0.0263	0.1555	1
Schistosoma mansoni	malate dehydrogenase	0.0549	0.3471	0.6449
Trypanosoma brucei	cytosolic malate dehydrogenase	0.0263	0.1555	0.2889
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0191	0.123
Schistosoma mansoni	hypothetical protein	0.0452	0.2821	0.5242
Echinococcus granulosus	lamin	0.0056	0.0175	0.0175
Leishmania major	cytosolic malate dehydrogenase	0.0263	0.1555	0.2833
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0592	0.3759	0.6985
Echinococcus granulosus	carbonic anhydrase	0.0452	0.2821	0.2821
Brugia malayi	Cathepsin L-like precursor	0.0059	0.0191	0.0269
Brugia malayi	Cathepsin L-like precursor	0.0039	0.0061	0.0086
Brugia malayi	cathepsin L-like precursor	0.0039	0.0061	0.0086
Entamoeba histolytica	malate dehydrogenase, putative	0.0549	0.3471	1
Entamoeba histolytica	cysteine proteinase, putative	0.0039	0.0061	0.0175
Leishmania major	cathepsin L-like protease	0.0059	0.0191	0.0279
Leishmania major	4-coumarate:coa ligase-like protein	0.0097	0.0447	0.0758
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0156	0.0841	0.1562
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0834	0.5382	0.7549
Leishmania major	cathepsin L-like protease	0.0156	0.0841	0.1496
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0069	0.0256	0.081
Brugia malayi	Papain family cysteine protease containing protein	0.0059	0.0191	0.0269
Loa Loa (eye worm)	matrix metalloproteinase	0.0354	0.2164	0.3
Leishmania major	malate dehydrogenase, putative	0.0237	0.138	0.2506
Trypanosoma cruzi	cruzipain precursor, putative	0.0156	0.0841	0.1562
Echinococcus multilocularis	carbonic anhydrase	0.0452	0.2821	0.2821
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0191	0.123
Plasmodium falciparum	malate dehydrogenase	0.0549	0.3471	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0191	0.123
Schistosoma mansoni	L-lactate dehydrogenase	0.0549	0.3471	0.6449
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.0191	0.0551
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0191	0.123
Mycobacterium leprae	PROBABLE HYDROLASE	0.0431	0.268	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0452	0.2821	0.3965
Echinococcus multilocularis	carbonic anhydrase	0.0452	0.2821	0.2821
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0156	0.0841	0.1562
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.0191	0.123
Echinococcus multilocularis	lactate dehydrogenase a	0.0549	0.3471	0.3471
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0156	0.0841	0.1562
Brugia malayi	Cathepsin L-like precursor	0.0059	0.0191	0.0269
Echinococcus granulosus	cathepsin l1	0.0039	0.0061	0.0061
Schistosoma mansoni	hypothetical protein	0.0502	0.3154	0.586
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0156	0.0841	0.1562
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0069	0.0256	0.081
Echinococcus granulosus	cytosolic malate dehydrogenase	0.0263	0.1555	0.1555
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0156	0.0841	0.1562
Onchocerca volvulus		0.0059	0.0191	0.0198
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0059	0.0191	0.0551
Trypanosoma cruzi	cysteine peptidase, putative	0.0156	0.0841	0.1562
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.0191	0.123
Loa Loa (eye worm)	hypothetical protein	0.0452	0.2821	0.3929
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0084	0.0356	0.1191
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0059	0.0191	0.0191

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	0	In vitro inhibition of estrogen-induced proliferation of cultured T-47D human breast cancer cells, at a concentration of 0.1 microM	ChEMBL.	10522700

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 255505

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 156872