Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | methionyl-tRNA synthetase, putative | 0.0066 | 0.3784 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1767 | 0.1767 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0041 | 0.1758 | 0.1758 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 0.3784 |
Brugia malayi | methionyl-tRNA synthetase | 0.0025 | 0.0503 | 0.0503 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0066 | 0.3784 | 1 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0025 | 0.0503 | 0.133 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0066 | 0.3784 | 0.5 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0025 | 0.0503 | 0.133 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0503 | 0.0503 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0025 | 0.0503 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3289 | 0.3289 |
Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 0.3784 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0066 | 0.3784 | 1 |
Onchocerca volvulus | 0.0041 | 0.1758 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0503 | 0.0503 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0025 | 0.0503 | 0.133 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3289 | 0.3289 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0025 | 0.0503 | 0.133 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0066 | 0.3784 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3289 | 0.3289 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3289 | 0.3289 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0025 | 0.0503 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1767 | 0.4669 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0503 | 0.0503 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0066 | 0.3784 | 0.5 |
Brugia malayi | protein ZK524.3 | 0.0025 | 0.0503 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1767 | 0.1767 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0025 | 0.0503 | 0.5 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0025 | 0.0503 | 0.133 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0066 | 0.3784 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0025 | 0.0503 | 0.5 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0025 | 0.0503 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.3784 | 1 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0066 | 0.3784 | 0.5 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0066 | 0.3784 | 0.5 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0066 | 0.3784 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 4.901 uM | PubChem BioAssay. Luminescence-based biochemical high throughput dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 10.274 uM | PubChem BioAssay. Counterscreen Fluorescent Polarization-based biochemical high throughput orthogonal dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.7783 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.